| Tag | Content |
|---|---|
| UniProt Accession | TP53B_HUMAN; Q12888; |
| Entrez ID | 7158 |
| GenBank Protein ID | NM_001141979.1; NM_001141980.1; NM_005657.2; |
| GenBank Nucleotide ID | NP_001135451.1; NP_001135452.1; NP_005648.1; |
| Protein Name | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) |
| Gene Name | TP53BP1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:(view all) |
| Sequence (Fasta) | MDPTGSQLDS DFSQQDTPCL IIEDSQPESQ VLEDDSGSHF SMLSRHLPNL QTHKENPVLD 60 VVSNPEQTAG EERGDGNSGF NEHLKENKVA DPVDSSNLDT CGSISQVIEQ LPQPNRTSSV 120 LGMSVESAPA VEEEKGEELE QKEKEKEEDT SGNTTHSLGA EDTASSQLGF GVLELSQSQD 180 VEENTVPYEV DKEQLQSVTT NSGYTRLSDV DANTAIKHEE QSNEDIPIAE QSSKDIPVTA 240 QPSKDVHVVK EQNPPPARSE DMPFSPKASV AAMEAKEQLS AQELMESGLQ IQKSPEPEVL 300 STQEDLFDQS NKTVSSDGCS TPSREEGGCS LASTPATTLH LLQLSGQRSL VQDSLSTNSS 360 DLVAPSPDAF RSTPFIVPSS PTEQEGRQDK PMDTSVLSEE GGEPFQKKLQ SGEPVELENP 420 PLLPESTVSP QASTPISQST PVFPPGSLPI PSQPQFSHDI FIPSPSLEEQ SNDGKKDGDM 480 HSSSLTVECS KTSEIEPKNS PEDLGLSLTG DSCKLMLSTS EYSQSPKMES LSSHRIDEDG 540 ENTQIEDTEP MSPVLNSKFV PAENDSILMN PAQDGEVQLS QNDDKTKGDD TDTRDDISIL 600 ATGCKGREET VAEDVCIDLT CDSGSQAVPS PATRSEALSS VLDQEEAMEI KEHHPEEGSS 660 GSEVEEIPET PCESQGEELK EENMESVPLH LSLTETQSQG LCLQKEMPKK ECSEAMEVET 720 SVISIDSPQK LAILDQELEH KEQEAWEEAT SEDSSVVIVD VKEPSPRVDV SCEPLEGVEK 780 CSDSQSWEDI APEIEPCAEN RLDTKEEKSV EYEGDLKSGT AETEPVEQDS SQPSLPLVRA 840 DDPLRLDQEL QQPQTQEKTS NSLTEDSKMA NAKQLSSDAE AQKLGKPSAH ASQSFCESSS 900 ETPFHFTLPK EGDIIPPLTG ATPPLIGHLK LEPKRHSTPI GISNYPESTI ATSDVMSESM 960 VETHDPILGS GKGDSGAAPD VDDKLCLRMK LVSPETEASE ESLQFNLEKP ATGERKNGST 1020 AVAESVASPQ KTMSVLSCIC EARQENEARS EDPPTTPIRG NLLHFPSSQG EEEKEKLEGD 1080 HTIRQSQQPM KPISPVKDPV SPASQKMVIQ GPSSPQGEAM VTDVLEDQKE GRSTNKENPS 1140 KALIERPSQN NIGIQTMECS LRVPETVSAA TQTIKNVCEQ GTSTVDQNFG KQDATVQTER 1200 GSGEKPVSAP GDDTESLHSQ GEEEFDMPQP PHGHVLHRHM RTIREVRTLV TRVITDVYYV 1260 DGTEVERKVT EETEEPIVEC QECETEVSPS QTGGSSGDLG DISSFSSKAS SLHRTSSGTS 1320 LSAMHSSGSS GKGAGPLRGK TSGTEPADFA LPSSRGGPGK LSPRKGVSQT GTPVCEEDGD 1380 AGLGIRQGGK APVTPRGRGR RGRPPSRTTG TRETAVPGPL GIEDISPNLS PDDKSFSRVV 1440 PRVPDSTRRT DVGAGALRRS DSPEIPFQAA AGPSDGLDAS SPGNSFVGLR VVAKWSSNGY 1500 FYSGKITRDV GAGKYKLLFD DGYECDVLGK DILLCDPIPL DTEVTALSED EYFSAGVVKG 1560 HRKESGELYY SIEKEGQRKW YKRMAVILSL EQGNRLREQY GLGPYEAVTP LTKAADISLD 1620 NLVEGKRKRR SNVSSPATPT ASSSSSTTPT RKITESPRAS MGVLSGKRKL ITSEEERSPA 1680 KRGRKSATVK PGAVGAGEFV SPCESGDNTG EPSALEEQRG PLPLNKTLFL GYAFLLTMAT 1740 TSDKLASRSK LPDGPTGSSE EEEEFLEIPP FNKQYTESQL RAGAGYILED FNEAQCNTAY 1800 QCLLIADQHC RTRKYFLCLA SGIPCVSHVW VHDSCHANQL QNYRNYLLPA GYSLEEQRIL 1860 DWQPRENPFQ NLKVLLVSDQ QQNFLELWSE ILMTGGAASV KQHHSSAHNK DIALGVFDVV 1920 VTDPSCPASV LKCAEALQLP VVSQEWVIQC LIVGERIGFK QHPKYKHDYV SH 1973 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 10) (view all) | rs16957715; Coronary heart disease; coronary artery disease
rs2602141; Parkinson's disease; Parkinson's disease rs12899865; Coronary heart disease; coronary artery disease rs690367; Tumor biomarkers; squamous cell carcinoma|pancreatic cancer|esophageal cancer|hepatocellular carcinoma rs2439832; Attention deficit hyperactivity disorder; attention deficit hyperactivity disorder rs17782975; Parkinson's disease; Parkinson's disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 264) (view all) | 100 VDSSNLDTCGSISQV dbPAF
1002 ETEASEESLQFNLEK dbPAF 1012 FNLEKPATGERKNGS dbPAF 1019 TGERKNGSTAVAESV dbPAF 1020 GERKNGSTAVAESVA dbPAF 1025 GSTAVAESVASPQKT dbPAF |
| Acetylation (count: 19) (view all) | 1009 SLQFNLEKPATGERK PLMD
1141 TNKENPSKALIERPS PLMD 1191 TVDQNFGKQDATVQT PLMD 1332 HSSGSSGKGAGPLRG PLMD 1360 SSRGGPGKLSPRKGV PLMD 1494 VGLRVVAKWSSNGYF PLMD |
| Ubiquitination (count: 21) (view all) | 1009 SLQFNLEKPATGERK PLMD
1191 TVDQNFGKQDATVQT PLMD 1268 DGTEVERKVTEETEE PLMD 1308 DISSFSSKASSLHRT PLMD 1340 GAGPLRGKTSGTEPA PLMD 1365 PGKLSPRKGVSQTGT PLMD |
| Sumoylation (count: 7) (view all) | 1365 PGKLSPRKGVSQTGT PLMD
1434 PNLSPDDKSFSRVVP PLMD 1563 GVVKGHRKESGELYY PLMD 217 VDANTAIKHEEQSNE PLMD 868 NSLTEDSKMANAKQL PLMD 930 PPLIGHLKLEPKRHS PLMD |
| Malonylation (count: 1) | 1332 HSSGSSGKGAGPLRG PLMD |
| Methylation (count: 3) | 1175 SAATQTIKNVCEQGT PLMD
135 APAVEEEKGEELEQK PLMD 1626 LDNLVEGKRKRRSNV PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |