Q08639

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession TFDP1_MOUSE; Q08639;
Entrez ID 21781
GenBank Protein ID NM_001291765.1; NM_009361.3; XM_006508751.3;
GenBank Nucleotide ID NP_001278694.1; NP_033387.1; XP_006508814.1;
Protein Name Transcription factor Dp-1 (DRTF1-polypeptide 1) (E2F dimerization partner 1)
Gene Name Tfdp1
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionCan stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Sequence
(Fasta)		MAKDASLIEA NGELKVFIDQ NLSPGKGVVS LVAVHPSTVN TLGKQLLPKT FGQSNVNITQ 60
QVVIGTPQRP AASNTIVVGS PHTPNTHFVS QNQTSDSSPW SAGKRNRKGE KNGKGLRHFS 120
MKVCEKVQRK GTTSYNEVAD ELVAEFSAAD NHILPNESAY DQKNIRRRVY DALNVLMAMN 180
IISKEKKEIK WIGLPTNSAQ ECQNLEVERQ RRLERIKQKQ SQLQELILQQ IAFKNLVQRN 240
RQAEQQARRP PPPNSVIHLP FIIVNTSRKT VIDCSISNDK FEYLFNFDNT FEIHDDIEVL 300
KRMGMACGLE SGNCSAEDLK VARSLVPKAL EPYVTEMAQG SIGGVFVTTT GSTSNGTRLS 360
ASDLSNGADG MLATSSNGSQ YSGSRVETPV SYVGEDDDDD DDFNENDEED 411

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationAdenocarcinomaA14633688
[Reference]: The phosphorylated form of DP-1 was not found at the 7-month irreversible stage or in adenocarcinomas.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)		MESH:D001171 ; Arthritis, Juvenile

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 5)		 23        VFIDQNLSPGKGVVS     dbPAF
30        SPGKGVVSLVAVHPS     dbPAF
388       YSGSRVETPVSYVGE     dbPAF
391       SRVETPVSYVGEDDD     dbPAF
6         **MAKDASLIEANGE     dbPAF
Acetylation
(count: 1)		 3         *****MAKDASLIEA     PLMD