Q08369

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession GATA4_MOUSE; Q08369;
Entrez ID 14463
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Transcription factor GATA-4 (GATA-binding factor 4)
Gene Name Gata4; Gata-4
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionTranscriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (PubMed:9584153). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (By similarity).
Sequence
(Fasta)		MYQSLAMAAN HGPPPGAYEA GGPGAFMHSA GAASSPVYVP TPRVPSSVLG LSYLQGGGSA 60
AAAGTTSGGS SGAGPSGAGP GTQQGSPGWS QAGAEGAAYT PPPVSPRFSF PGTTGSLAAA 120
AAAAAAREAA AYGSGGGAAG AGLAGREQYG RPGFAGSYSS PYPAYMADVG ASWAAAAAAS 180
AGPFDSPVLH SLPGRANPGR HPNLDMFDDF SEGRECVNCG AMSTPLWRRD GTGHYLCNAC 240
GLYHKMNGIN RPLIKPQRRL SASRRVGLSC ANCQTTTTTL WRRNAEGEPV CNACGLYMKL 300
HGVPRPLAMR KEGIQTRKRK PKNLNKSKTP AGPAGETLPP SSGASSGNSS NATSSSSSSE 360
EMRPIKTEPG LSSHYGHSSS MSQTFSTVSG HGPSIHPVLS ALKLSPQGYA SPVTQTSQAS 420
SKQDSWNSLV LADSHGDIIT A 442

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationHeart failureUS10521746915
[Reference]: Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 11)
(view all)		MESH:D000437 ; Alcoholism
MESH:C538263 ; Atrial septal defect 2
MESH:C562831 ; Atrioventricular Septal Defect
MESH:D006332 ; Cardiomegaly
MESH:D015179 ; Colorectal Neoplasms
MESH:D006345 ; Heart Septal Defects, Ventricular

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 4)		 105       AYTPPPVSPRFSFPG     dbPAF
160       GFAGSYSSPYPAYMA     dbPAF
261       IKPQRRLSASRRVGL     dbPAF
367       EEMRPIKTEPGLSSH     dbPAF