| Tag | Content |
|---|---|
| UniProt Accession | DDR1_HUMAN; Q08345; |
| Entrez ID | 780 |
| GenBank Protein ID | NM_001202521.1; NM_001202522.1; NM_001202523.1; NM_001297652.1; NM_001297653.1; NM_001297654.1; NM_001954.4; NM_013993.2; NM_013994.2; |
| GenBank Nucleotide ID | NP_001189450.1; NP_001189451.1; NP_001189452.1; NP_001284581.1; NP_001284582.1; NP_001284583.1; NP_001945.3; NP_054699.2; NP_054700.2; |
| Protein Name | Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protei |
| Gene Name | DDR1; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. |
| Sequence (Fasta) | MGPEALSSLL LLLLVASGDA DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR 60 HSRLESSDGD GAWCPAGSVF PKEEEYLQVD LQRLHLVALV GTQGRHAGGL GKEFSRSYRL 120 RYSRDGRRWM GWKDRWGQEV ISGNEDPEGV VLKDLGPPMV ARLVRFYPRA DRVMSVCLRV 180 ELYGCLWRDG LLSYTAPVGQ TMYLSEAVYL NDSTYDGHTV GGLQYGGLGQ LADGVVGLDD 240 FRKSQELRVW PGYDYVGWSN HSFSSGYVEM EFEFDRLRAF QAMQVHCNNM HTLGARLPGG 300 VECRFRRGPA MAWEGEPMRH NLGGNLGDPR ARAVSVPLGG RVARFLQCRF LFAGPWLLFS 360 EISFISDVVN NSSPALGGTF PPAPWWPPGP PPTNFSSLEL EPRGQQPVAK AEGSPTAILI 420 GCLVAIILLL LLIIALMLWR LHWRRLLSKA ERRVLEEELT VHLSVPGDTI LINNRPGPRE 480 PPPYQEPRPR GNPPHSAPCV PNGSALLLSN PAYRLLLATY ARPPRGPGPP TPAWAKPTNT 540 QAYSGDYMEP EKPGAPLLPP PPQNSVPHYA EADIVTLQGV TGGNTYAVPA LPPGAVGDGP 600 PRVDFPRSRL RFKEKLGEGQ FGEVHLCEVD SPQDLVSLDF PLNVRKGHPL LVAVKILRPD 660 ATKNARNDFL KEVKIMSRLK DPNIIRLLGV CVQDDPLCMI TDYMENGDLN QFLSAHQLED 720 KAAEGAPGDG QAAQGPTISY PMLLHVAAQI ASGMRYLATL NFVHRDLATR NCLVGENFTI 780 KIADFGMSRN LYAGDYYRVQ GRAVLPIRWM AWECILMGKF TTASDVWAFG VTLWEVLMLC 840 RAQPFGQLTD EQVIENAGEF FRDQGRQVYL SRPPACPQGL YELMLRCWSR ESEQRPPFSQ 900 LHRFLAEDAL NTV 914 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 4) | MESH:D000230
; Adenocarcinoma MESH:D008175 ; Lung Neoplasms MESH:D008325 ; Mammary Neoplasms, Experimental MESH:D011471 ; Prostatic Neoplasms |
| HGMD (count: 1) | CM076148; Schizophrenia, association with; Missense/nonsense
|
| GWASdb (count: 31) (view all) | rs9501032; HIV-1 control; Human immunodeficiency virus infectious disease
rs1264327; Behcet's disease; Behcet's disease rs9461638; HIV-1 control; Human immunodeficiency virus infectious disease rs7757648; Prostate cancer; prostate cancer rs1264325; Sarcoidosis; sarcoidosis rs9468842; HIV-1 control; Human immunodeficiency virus infectious disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 16) (view all) | 45 QDRTIPDSDISASSS dbPAF
469 HLSVPGDTILINNRP dbPAF 484 GPREPPPYQEPRPRG dbPAF 496 PRGNPPHSAPCVPNG dbPAF 513 LLLSNPAYRLLLATY dbPAF 519 AYRLLLATYARPPRG dbPAF |
| Ubiquitination (count: 5) | 112 RHAGGLGKEFSRSYR PLMD
153 DPEGVVLKDLGPPMV PLMD 30 KGHFDPAKCRYALGM PLMD 663 ILRPDATKNARNDFL PLMD 671 NARNDFLKEVKIMSR PLMD |
| Methylation (count: 2) | 613 PRSRLRFKEKLGEGQ PLMD
615 SRLRFKEKLGEGQFG PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |