| Tag | Content |
|---|---|
| UniProt Accession | FOXM1_HUMAN; Q08050; |
| Entrez ID | 2305 |
| GenBank Protein ID | NM_001243088.1; NM_001243089.1; NM_021953.3; NM_202002.2; NM_202003.2; |
| GenBank Nucleotide ID | NP_001230017.1; NP_001230018.1; NP_068772.2; NP_973731.1; NP_973732.1; |
| Protein Name | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix fac |
| Gene Name | FOXM1; FKHL16; HFH11; MPP2; WIN |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. |
| Sequence (Fasta) | MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 60 GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 120 LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCADG EAAGCTINNS 180 LSNIQWLRKM SSDGLGSRSI KQEMEEKENC HLEQRQVKVE EPSRPSASWQ NSVSERPPYS 240 YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS 300 ANGKVSFWTI HPSANRYLTL DQVFKPLDPG SPQLPEHLES QQKRPNPELR RNMTIKTELP 360 LGARRKMKPL LPRVSSYLVP IQFPVNQSLV LQPSVKVPLP LAASLMSSEL ARHSKRVRIA 420 PKVLLAEEGI APLSSAGPGK EEKLLFGEGF SPLLPVQTIK EEEIQPGEEM PHLARPIKVE 480 SPPLEEWPSP APSFKEESSH SWEDSSQSPT PRPKKSYSGL RSPTRCVSEM LVIQHRERRE 540 RSRSRRKQHL LPPCVDEPEL LFSEGPSTSR WAAELPFPAD SSDPASQLSY SQEVGGPFKT 600 PIKETLPISS TPSKSVLPRT PESWRLTPPA KVGGLDFSPV QTSQGASDPL PDPLGLMDLS 660 TTPLQSAPPL ESPQRLLSSE PLDLISVPFG NSSPSDIDVP KPGSPEPQVS GLAANRSLTE 720 GLVLDTMNDS LSKILLDISF PGLDEDPLGP DNINWSQFIP ELQ 764 |
|
||||||||||||||||||||
| Database | Annotation |
|---|---|
| CTD (Curated) (count: 8) (view all) | MESH:D001943
; Breast Neoplasms MESH:D006528 ; Carcinoma, Hepatocellular MESH:D005922 ; Glomerulonephritis, IGA MESH:D007938 ; Leukemia MESH:D008114 ; Liver Neoplasms, Experimental MESH:D008175 ; Lung Neoplasms |
| DisGeNet (Curated) (count: 8) (view all) | C0007131; Non-Small Cell Lung Carcinoma
C0017661; IGA Glomerulonephritis C0023418; leukemia C0023904; Liver Neoplasms, Experimental C0024121; Lung Neoplasms C0032927; Precancerous Conditions |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 45) (view all) | 191 IQWLRKMSSDGLGSR dbPAF
251 MIQFAINSTERKRMT dbPAF 252 IQFAINSTERKRMTL dbPAF 306 TSANGKVSFWTIHPS dbPAF 319 PSANRYLTLDQVFKP dbPAF 331 FKPLDPGSPQLPEHL dbPAF |
| Ubiquitination (count: 3) | 325 LTLDQVFKPLDPGSP PLMD
440 LSSAGPGKEEKLLFG PLMD 443 AGPGKEEKLLFGEGF PLMD |
| Sumoylation (count: 9) (view all) | 201 GLGSRSIKQEMEEKE PLMD
218 HLEQRQVKVEEPSRP PLMD 356 LRRNMTIKTELPLGA PLMD 422 KRVRIAPKVLLAEEG PLMD 440 LSSAGPGKEEKLLFG PLMD 460 LLPVQTIKEEEIQPG PLMD |
| Methylation (count: 2) | 278 PYFKHIAKPGWKNSI PLMD
282 HIAKPGWKNSIRHNL PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |