| Tag | Content |
|---|---|
| UniProt Accession | MCL1_HUMAN; Q07820; |
| Entrez ID | 4170 |
| GenBank Protein ID | NM_001197320.1; NM_021960.4; NM_182763.2; |
| GenBank Nucleotide ID | NP_001184249.1; NP_068779.1; NP_877495.1; |
| Protein Name | Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT) |
| Gene Name | MCL1; BCL2L3 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. |
| Sequence (Fasta) | MFGLKRNAVI GLNLYCGGAG LGAGSGGATR PGGRLLATEK EASARREIGG GEAGAVIGGS 60 AGASPPSTLT PDSRRVARPP PIGAEVPDVT ATPARLLFFA PTRRAAPLEE MEAPAADAIM 120 SPEEELDGYE PEPLGKRPAV LPLLELVGES GNNTSTDGSL PSTPPPAEEE EDELYRQSLE 180 IISRYLREQA TGAKDTKPMG RSGATSRKAL ETLRRVGDGV QRNHETAFQG MLRKLDIKNE 240 DDVKSLSRVM IHVFSDGVTN WGRIVTLISF GAFVAKHLKT INQESCIEPL AESITDVLVR 300 TKRDWLVKQR GWDGFVEFFH VEDLEGGIRN VLLAFAGVAG VGAGLAYLIR 351 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 6) | MESH:D001471
; Barrett Esophagus MESH:D007896 ; Leishmaniasis MESH:D008175 ; Lung Neoplasms MESH:D016410 ; Lymphoma, T-Cell, Cutaneous MESH:D009101 ; Multiple Myeloma MESH:D012509 ; Sarcoma |
| DisGeNet (Curated) (count: 6) | C0004763; Barrett Esophagus
C0023281; Leishmaniasis C0024121; Lung Neoplasms C0026764; Multiple Myeloma C0079773; Lymphoma, T-Cell, Cutaneous C1261473; Sarcoma |
| GWASdb (count: 1) | rs1913117; Triglycerides; coronary artery disease|lipid metabolism disorder|arteriosclerosis |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 12) (view all) | 121 PAADAIMSPEEELDG dbPAF
129 PEEELDGYEPEPLGK dbPAF 150 LLELVGESGNNTSTD dbPAF 154 VGESGNNTSTDGSLP dbPAF 159 NNTSTDGSLPSTPPP dbPAF 162 STDGSLPSTPPPAEE dbPAF |
| Ubiquitination (count: 10) (view all) | 136 YEPEPLGKRPAVLPL PLMD
194 REQATGAKDTKPMGR PLMD 197 ATGAKDTKPMGRSGA PLMD 234 AFQGMLRKLDIKNED PLMD 238 MLRKLDIKNEDDVKS PLMD 244 IKNEDDVKSLSRVMI PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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