| Tag | Content |
|---|---|
| UniProt Accession | PRDX1_HUMAN; Q06830; |
| Entrez ID | 5052 |
| GenBank Protein ID | NM_001202431.1; NM_002574.3; NM_181696.2; NM_181697.2; |
| GenBank Nucleotide ID | NP_001189360.1; NP_002565.1; NP_859047.1; NP_859048.1; |
| Protein Name | Peroxiredoxin-1 (EC 1.11.1.15) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) |
| Gene Name | PRDX1; PAGA; PAGB; TDPX2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). |
| Sequence (Fasta) | MSSGNAKIGH PAPNFKATAV MPDGQFKDIS LSDYKGKYVV FFFYPLDFTF VCPTEIIAFS 60 DRAEEFKKLN CQVIGASVDS HFCHLAWVNT PKKQGGLGPM NIPLVSDPKR TIAQDYGVLK 120 ADEGISFRGL FIIDDKGILR QITVNDLPVG RSVDETLRLV QAFQFTDKHG EVCPAGWKPG 180 SDTIKPDVQK SKEYFSKQK |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 6) | MESH:D001195
; Asbestosis MESH:C562729 ; Esophageal Squamous Cell Carcinoma MESH:D007627 ; Keloid MESH:D008175 ; Lung Neoplasms MESH:D002289 ; Carcinoma, Non-Small-Cell Lung MESH:D012552 ; Schistosomiasis |
| GWASdb (count: 3) | rs4660306; Homocysteine levels; atherosclerosis|coronary artery disease
rs16832557; Multiple complex diseases; Null rs10736426; Amyotrophic lateral sclerosis (sporadic); amyotrophic lateral sclerosis |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 16) (view all) | 106 PMNIPLVSDPKRTIA dbPAF
111 LVSDPKRTIAQDYGV dbPAF 116 KRTIAQDYGVLKADE dbPAF 126 LKADEGISFRGLFII dbPAF 143 KGILRQITVNDLPVG dbPAF 152 NDLPVGRSVDETLRL dbPAF |
| Acetylation (count: 16) (view all) | 109 IPLVSDPKRTIAQDY PLMD
120 AQDYGVLKADEGISF PLMD 136 GLFIIDDKGILRQIT PLMD 16 GHPAPNFKATAVMPD PLMD 168 QAFQFTDKHGEVCPA PLMD 178 EVCPAGWKPGSDTIK PLMD |
| Ubiquitination (count: 17) (view all) | 109 IPLVSDPKRTIAQDY PLMD
120 AQDYGVLKADEGISF PLMD 136 GLFIIDDKGILRQIT PLMD 16 GHPAPNFKATAVMPD PLMD 168 QAFQFTDKHGEVCPA PLMD 185 KPGSDTIKPDVQKSK PLMD |
| Sumoylation (count: 6) | 120 AQDYGVLKADEGISF PLMD
16 GHPAPNFKATAVMPD PLMD 185 KPGSDTIKPDVQKSK PLMD 192 KPDVQKSKEYFSKQK PLMD 7 *MSSGNAKIGHPAPN PLMD 93 AWVNTPKKQGGLGPM PLMD |
| Glycation (count: 2) | 120 AQDYGVLKADEGISF PLMD
16 GHPAPNFKATAVMPD PLMD |
| Malonylation (count: 10) (view all) | 109 IPLVSDPKRTIAQDY PLMD
16 GHPAPNFKATAVMPD PLMD 178 EVCPAGWKPGSDTIK PLMD 185 KPGSDTIKPDVQKSK PLMD 197 KSKEYFSKQK***** PLMD 27 VMPDGQFKDISLSDY PLMD |
| Succinylation (count: 8) (view all) | 109 IPLVSDPKRTIAQDY PLMD
120 AQDYGVLKADEGISF PLMD 136 GLFIIDDKGILRQIT PLMD 16 GHPAPNFKATAVMPD PLMD 27 VMPDGQFKDISLSDY PLMD 35 DISLSDYKGKYVVFF PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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