Q06481

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession APLP2_HUMAN; Q06481;
Entrez ID 334
GenBank Protein ID NM_001142276.1; NM_001142277.1; NM_001142278.1; NM_001243299.1; NM_001642.2;
GenBank Nucleotide ID NP_001135748.1; NP_001135749.1; NP_001135750.1; NP_001230228.1; NP_001633.1;
Protein Name Amyloid-like protein 2 (APLP-2) (APPH) (Amyloid protein homolog) (CDEI box-binding protein) (CDEBP)
Gene Name APLP2; APPL2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMay play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).
Sequence
(Fasta)		MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN 60
MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI TNVMEANQRV SIDNWCRRDK 120
KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ FFHKERMEVC ENHQHWHTVV KEACLTQGMT 180
LYSYGMLLPC GVDQFHGTEY VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF 240
PTEADLEDFT EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK 300
EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF ESEDYCMAVC 360
KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR HRNRMDRVKK EWEEAELQAK 420
NLPKAERQTL IQHFQAMVKA LEKEAASEKQ QLVETHLARV EAMLNDRRRM ALENYLAALQ 480
SDPPRPHRIL QALRRYVRAE NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR 540
NQSLSLLYKV PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH 600
PFHPFPALPE NEDTQPELYH PMKKGSGVGE QDGGLIGAEE KVINSKNKVD ENMVIDETLD 660
VKEMIFNAER VGGLEEERES VGPLREDFSL SSSALIGLLV IAVAIATVIV ISLVMLRKRQ 720
YGTISHGIVE VDPMLTPEER HLNKMQNHGY ENPTYKYLEQ MQI 764

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationAlzheimer's diseaseUT73614970211
[Reference]: Here we demonstrate that both APP and APLP2 can be phosphorylated by JNK at the Thr(668) and Thr(736) residues, respectively

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)		MESH:D017202 ; Myocardial Ischemia
MESH:D009410 ; Nerve Degeneration
DisGeNet (Curated)
(count: 2)		C0027746; Nerve Degeneration
C0151744; Myocardial Ischemia
GWASdb
(count: 1)		rs12278451; Cytomegalovirus antibody response; viral pneumonia

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 10)
(view all)		 211       PQTKIIGSVSKEEEE     dbPAF
213       TKIIGSVSKEEEEED     dbPAF
303       TMSDKEITHDVKAVC     dbPAF
531       QMKSQVMTHLHVIEE     dbPAF
723       LRKRQYGTISHGIVE     dbPAF
736       VEVDPMLTPEERHLN     dbPAF
Ubiquitination
(count: 5)		 148       DVLLVPEKCQFFHKE     PLMD
154       EKCQFFHKERMEVCE     PLMD
521       VLAVDPEKAAQMKSQ     PLMD
744       PEERHLNKMQNHGYE     PLMD
756       GYENPTYKYLEQMQI     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource