Q06455

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession MTG8_HUMAN; Q06455;
Entrez ID 862
GenBank Protein ID NM_001198625.1; NM_001198626.1; NM_001198627.1; NM_001198628.1; NM_001198629.1; NM_001198630.1; NM_001198631.1; NM_001198632.1; NM_001198633.1; NM_001198634.1; NM_001198679.1; NM_004349.3; NM_175634.2; NM_175635.2; NM_175636.2; XM_006716676.3; XM_011517351.2; XM_011517352.2; XM_011517353.2; XM_017013931.1; XM_017013932.1; XM_017013933.1; XM_017013934.1; XM_017013935.1; XM_017013936.1; XM_017013937.1;
GenBank Nucleotide ID NP_001185554.1; NP_001185555.1; NP_001185556.1; NP_001185557.1; NP_001185558.1; NP_001185559.1; NP_001185560.1; NP_001185561.1; NP_001185562.1; NP_001185563.1; NP_001185608.1; NP_004340.1; NP_783552.1; NP_783553.1; NP_783554.1; XP_006716739.1; XP_011515653.1; XP_011515654.1; XP_011515655.1; XP_016869420.1; XP_016869421.1; XP_016869422.1; XP_016869423.1; XP_016869424.1; XP_016869425.1; XP_016869426.1;
Protein Name Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2)
Gene Name RUNX1T1; AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTranscriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588).
Sequence
(Fasta)		MISVKRNTWR ALSLVIGDCR KKGNFEYCQD RTEKHSTMPD SPVDVKTQSR LTPPTMPPPP 60
TTQGAPRTSS FTPTTLTNGT SHSPTALNGA PSPPNGFSNG PSSSSSSSLA NQQLPPACGA 120
RQLSKLKRFL TTLQQFGNDI SPEIGERVRT LVLGLVNSTL TIEEFHSKLQ EATNFPLRPF 180
VIPFLKANLP LLQRELLHCA RLAKQNPAQY LAQHEQLLLD ASTTSPVDSS ELLLDVNENG 240
KRRTPDRTKE NGFDREPLHS EHPSKRPCTI SPGQRYSPNN GLSYQPNGLP HPTPPPPQHY 300
RLDDMAIAHH YRDSYRHPSH RDLRDRNRPM GLHGTRQEEM IDHRLTDREW AEEWKHLDHL 360
LNCIMDMVEK TRRSLTVLRR CQEADREELN YWIRRYSDAE DLKKGGGSSS SHSRQQSPVN 420
PDPVALDAHR EFLHRPASGY VPEEIWKKAE EAVNEVKRQA MTELQKAVSE AERKAHDMIT 480
TERAKMERTV AEAKRQAAED ALAVINQQED SSESCWNCGR KASETCSGCN TARYCGSFCQ 540
HKDWEKHHHI CGQTLQAQQQ GDTPAVSSSV TPNSGAGSPM DTPPAATPRS TTPGTPSTIE 600
TTPR 605

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1UbiquitinationAcute myeloid leukaemia/Acute myelogenous leukemiaKasumi-1 cellP24103869
[Reference]: Dexamethasone and vorinostat cooperatively promote differentiation and apoptosis in Kasumi-1 leukemia cells through ubiquitination and degradation of AML1-ETO

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
AML
CTD (Curated)
(count: 2)		MESH:D015470 ; Leukemia, Myeloid, Acute
MESH:D055752 ; Small Cell Lung Carcinoma
GWASdb
(count: 5)		rs4500123; Epilepsy; epilepsy syndrome
rs13252280; Response to cytidine analogues (gemcitabine); cancer
rs7461004; Response to cytidine analogues (gemcitabine); cancer
rs13273012; Response to cytidine analogues (gemcitabine); cancer
rs1552314; Response to cytidine analogues (gemcitabine); cancer

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 12)
(view all)		 315       AHHYRDSYRHPSHRD     dbPAF
41        KHSTMPDSPVDVKTQ     dbPAF
417       SSHSRQQSPVNPDPV     dbPAF
462       EVKRQAMTELQKAVS     dbPAF
47        DSPVDVKTQSRLTPP     dbPAF
52        VKTQSRLTPPTMPPP     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource