Tag | Content |
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UniProt Accession | TYRO3_HUMAN; Q06418; |
Entrez ID | 7301 |
GenBank Protein ID | NM_001330264.1; NM_006293.3; |
GenBank Nucleotide ID | NP_001317193.1; NP_006284.2; |
Protein Name | Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF) |
Gene Name | TYRO3; BYK; DTK; RSE; SKY; TIF |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT surviva(view all) |
Sequence (Fasta) | MALRRSMGRP GLPPLPLPPP PRLGLLLAAL ASLLLPESAA AGLKLMGAPV KLTVSQGQPV 60 KLNCSVEGME EPDIQWVKDG AVVQNLDQLY IPVSEQHWIG FLSLKSVERS DAGRYWCQVE 120 DGGETEISQP VWLTVEGVPF FTVEPKDLAV PPNAPFQLSC EAVGPPEPVT IVWWRGTTKI 180 GGPAPSPSVL NVTGVTQSTM FSCEAHNLKG LASSRTATVH LQALPAAPFN ITVTKLSSSN 240 ASVAWMPGAD GRALLQSCTV QVTQAPGGWE VLAVVVPVPP FTCLLRDLVP ATNYSLRVRC 300 ANALGPSPYA DWVPFQTKGL APASAPQNLH AIRTDSGLIL EWEEVIPEAP LEGPLGPYKL 360 SWVQDNGTQD ELTVEGTRAN LTGWDPQKDL IVRVCVSNAV GCGPWSQPLV VSSHDRAGQQ 420 GPPHSRTSWV PVVLGVLTAL VTAAALALIL LRKRRKETRF GQAFDSVMAR GEPAVHFRAA 480 RSFNRERPER IEATLDSLGI SDELKEKLED VLIPEQQFTL GRMLGKGEFG SVREAQLKQE 540 DGSFVKVAVK MLKADIIASS DIEEFLREAA CMKEFDHPHV AKLVGVSLRS RAKGRLPIPM 600 VILPFMKHGD LHAFLLASRI GENPFNLPLQ TLIRFMVDIA CGMEYLSSRN FIHRDLAARN 660 CMLAEDMTVC VADFGLSRKI YSGDYYRQGC ASKLPVKWLA LESLADNLYT VQSDVWAFGV 720 TMWEIMTRGQ TPYAGIENAE IYNYLIGGNR LKQPPECMED VYDLMYQCWS ADPKQRPSFT 780 CLRMELENIL GQLSVLSASQ DPLYINIERA EEPTAGGSLE LPGRDQPYSG AGDGSGMGAV 840 GGTPSDCRYI LTPGGLAEQP GQAEHQPESP LNETQRLLLL QQGLLPHSSC 891 |
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Database | Annotation |
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CTD (Curated) (count: 1) | MESH:D013927 ; Thrombosis |
GWASdb (count: 2) | rs1200341; Blood Pressure; hypertension
rs12259; Systemic lupus erythematosus; systemic lupus erythematosus |
PTM | Modification Sites |
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Phosphorylation (count: 14) (view all) | 307 CANALGPSPYADWVP dbPAF
427 QGPPHSRTSWVPVVL dbPAF 428 GPPHSRTSWVPVVLG dbPAF 466 RFGQAFDSVMARGEP dbPAF 543 QLKQEDGSFVKVAVK dbPAF 681 FGLSRKIYSGDYYRQ dbPAF |
Ubiquitination (count: 3) | 526 TLGRMLGKGEFGSVR PLMD
582 FDHPHVAKLVGVSLR PLMD 752 LIGGNRLKQPPECME PLMD |
Network | Interaction | ||
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A | B | Source | |