| Tag | Content |
|---|---|
| UniProt Accession | CALD1_HUMAN; Q05682; |
| Entrez ID | 800 |
| GenBank Protein ID | NM_004342.6; NM_033138.3; NM_033139.3; NM_033140.3; NM_033157.3; XM_017012651.1; XM_017012652.1; |
| GenBank Nucleotide ID | NP_004333.1; NP_149129.2; NP_149130.1; NP_149131.1; NP_149347.2; XP_016868140.1; XP_016868141.1; |
| Protein Name | Caldesmon (CDM) |
| Gene Name | CALD1; CAD; CDM |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). |
| Sequence (Fasta) | MDDFERRREL RRQKREEMRL EAERIAYQRN DDDEEEAARE RRRRARQERL RQKQEEESLG 60 QVTDQVEVNA QNSVPDEEAK TTTTNTQVEG DDEAAFLERL ARREERRQKR LQEALERQKE 120 FDPTITDASL SLPSRRMQND TAENETTEKE EKSESRQERY EIEETETVTK SYQKNDWRDA 180 EENKKEDKEK EEEEEEKPKR GSIGENQVEV MVEEKTTESQ EETVVMSLKN GQISSEEPKQ 240 EEEREQGSDE ISHHEKMEEE DKERAEAERA RLEAEERERI KAEQDKKIAD ERARIEAEEK 300 AAAQERERRE AEERERMREE EKRAAEERQR IKEEEKRAAE ERQRIKEEEK RAAEERQRIK 360 EEEKRAAEER QRARAEEEEK AKVEEQKRNK QLEEKKHAMQ ETKIKGEKVE QKIEGKWVNE 420 KKAQEDKLQT AVLKKQGEEK GTKVQAKREK LQEDKPTFKK EEIKDEKIKK DKEPKEEVKS 480 FMDRKKGFTE VKSQNGEFMT HKLKHTENTF SRPGGRASVD TKEAEGAPQV EAGKRLEELR 540 RRRGETESEE FEKLKQKQQE AALELEELKK KREERRKVLE EEEQRRKQEE ADRKLREEEE 600 KRRLKEEIER RRAEAAEKRQ KMPEDGLSDD KKPFKCFTPK GSSLKIEERA EFLNKSVQKS 660 SGVKSTHQAA IVSKIDSRLE QYTSAIEGTK SAKPTKPAAS DLPVPAEGVR NIKSMWEKGN 720 VFSSPTAAGT PNKETAGLKV GVSSRINEWL TKTPDGNKSP APKPSDLRPG DVSSKRNLWE 780 KQSVDKVTSP TKV 794 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 2) | MESH:D001171
; Arthritis, Juvenile MESH:D001172 ; Arthritis, Rheumatoid |
| GWASdb (count: 17) (view all) | rs2347896; Alcohol dependence; alcohol dependence
rs6467557; Leukocyte Counts; leukemia|lymphoma|cardiovascular system disease rs1470841; Coronary restenosis; coronary artery disease rs17169635; Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); Human immunodeficiency virus infectious disease rs12707180; Mammographic density; female breast cancer rs759987; Coronary restenosis; coronary artery disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 53) (view all) | 126 KEFDPTITDASLSLP dbPAF
129 DPTITDASLSLPSRR dbPAF 131 TITDASLSLPSRRMQ dbPAF 141 SRRMQNDTAENETTE dbPAF 153 TTEKEEKSESRQERY dbPAF 160 SESRQERYEIEETET dbPAF |
| Acetylation (count: 14) (view all) | 149 AENETTEKEEKSESR PLMD
152 ETTEKEEKSESRQER PLMD 174 TVTKSYQKNDWRDAE PLMD 504 EFMTHKLKHTENTFS PLMD 53 RQERLRQKQEEESLG PLMD 553 TESEEFEKLKQKQQE PLMD |
| Ubiquitination (count: 8) (view all) | 170 EETETVTKSYQKNDW PLMD
522 GRASVDTKEAEGAPQ PLMD 53 RQERLRQKQEEESLG PLMD 534 APQVEAGKRLEELRR PLMD 655 ERAEFLNKSVQKSSG PLMD 718 NIKSMWEKGNVFSSP PLMD |
| Sumoylation (count: 3) | 152 ETTEKEEKSESRQER PLMD
631 EDGLSDDKKPFKCFT PLMD 645 TPKGSSLKIEERAEF PLMD |
| Malonylation (count: 14) (view all) | 479 KEPKEEVKSFMDRKK PLMD
502 NGEFMTHKLKHTENT PLMD 522 GRASVDTKEAEGAPQ PLMD 553 TESEEFEKLKQKQQE PLMD 605 EEEKRRLKEEIERRR PLMD 631 EDGLSDDKKPFKCFT PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |