Tag | Content |
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UniProt Accession | KPCD_HUMAN; Q05655; |
Entrez ID | 5580 |
GenBank Protein ID | NM_001316327.1; NM_006254.3; NM_212539.1; XM_006713259.2; XM_017006855.1; XM_017006856.1; |
GenBank Nucleotide ID | NP_001303256.1; NP_006245.2; NP_997704.1; XP_006713322.1; XP_016862344.1; XP_016862345.1; |
Protein Name | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SD |
Gene Name | PRKCD |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively r(view all) |
Sequence (Fasta) | MAPFLRIAFN SYELGSLQAE DEANQPFCAV KMKEALSTER GKTLVQKKPT MYPEWKSTFD 60 AHIYEGRVIQ IVLMRAAEEP VSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMSVQY 120 FLEDVDCKQS MRSEDEAKFP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKDFVW 180 GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTIF QKERFNIDMP HRFKVHNYMS 240 PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCREKVANLC GINQKLLAEA LNQVTQRASR 300 RSDSASSEPV GIYQGFEKKT GVAGEDMQDN SGTYGKIWEG SSKCNINNFI FHKVLGKGSF 360 GKVLLGELKG RGEYFAIKAL KKDVVLIDDD VECTMVEKRV LTLAAENPFL THLICTFQTK 420 DHLFFVMEFL NGGDLMYHIQ DKGRFELYRA TFYAAEIMCG LQFLHSKGII YRDLKLDNVL 480 LDRDGHIKIA DFGMCKENIF GESRASTFCG TPDYIAPEIL QGLKYTFSVD WWSFGVLLYE 540 MLIGQSPFHG DDEDELFESI RVDTPHYPRW ITKESKDILE KLFEREPTKR LGVTGNIKIH 600 PFFKTINWTL LEKRRLEPPF RPKVKSPRDY SNFDQEFLNE KARLSYSDKN LIDSMDQSAF 660 AGFSFVNPKF EHLLED 677 |
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Database | Annotation |
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CTD (Curated) (count: 8) (view all) | OMIM:615559
; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE III MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D006973 ; Hypertension MESH:D007414 ; Intestinal Neoplasms MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D020258 ; Neurotoxicity Syndromes |
PTM | Modification Sites |
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Phosphorylation (count: 50) (view all) | 120 KVLMSVQYFLEDVDC dbPAF
130 EDVDCKQSMRSEDEA dbPAF 133 DCKQSMRSEDEAKFP dbPAF 141 EDEAKFPTMNRRGAI dbPAF 155 IKQAKIHYIKNHEFI dbPAF 187 WGLNKQGYKCRQCNA dbPAF |
Acetylation (count: 1) | 353 INNFIFHKVLGKGSF PLMD |
Ubiquitination (count: 11) (view all) | 138 MRSEDEAKFPTMNRR PLMD
184 DFVWGLNKQGYKCRQ PLMD 222 SRDTIFQKERFNIDM PLMD 285 NLCGINQKLLAEALN PLMD 319 IYQGFEKKTGVAGED PLMD 336 DNSGTYGKIWEGSSK PLMD |