Q05469

※ Protein Information

Tag	Content
UniProt Accession	LIPS_HUMAN; Q05469;
Entrez ID	3991
GenBank Protein ID	NM_005357.3; XM_005258940.3; XM_006723218.2; XM_017026810.1;
GenBank Nucleotide ID	NP_005348.2; XP_005258997.1; XP_006723281.1; XP_016882299.1;
Protein Name	Hormone-sensitive lipase (HSL) (EC 3.1.1.79)
Gene Name	LIPE
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Functional Description In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Sequence (Fasta)	MEPGSKSVSR SDWQPEPHQR PITPLEPGPE KTPIAQPESK TLQGSNTQQK PASNQRPLTQ 60 QETPAQHDAE SQKEPRAQQK SASQEEFLAP QKPAPQQSPY IQRVLLTQQE AASQQGPGLG 120 KESITQQEPA LRQRHVAQPG PGPGEPPPAQ QEAESTPAAQ AKPGAKREPS APTESTSQET 180 PEQSDKQTTP VQGAKSKQGS LTELGFLTKL QELSIQRSAL EWKALSEWVT DSESESDVGS 240 SSDTDSPATM GGMVAQGVKL GFKGKSGYKV MSGYSGTSPH EKTSARNHRH YQDTASRLIH 300 NMDLRTMTQS LVTLAEDNIA FFSSQGPGET AQRLSGVFAG VREQALGLEP ALGRLLGVAH 360 LFDLDPETPA NGYRSLVHTA RCCLAHLLHK SRYVASNRRS IFFRTSHNLA ELEAYLAALT 420 QLRALVYYAQ RLLVTNRPGV LFFEGDEGLT ADFLREYVTL HKGCFYGRCL GFQFTPAIRP 480 FLQTISIGLV SFGEHYKRNE TGLSVAASSL FTSGRFAIDP ELRGAEFERI TQNLDVHFWK 540 AFWNITEMEV LSSLANMASA TVRVSRLLSL PPEAFEMPLT ADPTLTVTIS PPLAHTGPGP 600 VLVRLISYDL REGQDSEELS SLIKSNGQRS LELWPRPQQA PRSRSLIVHF HGGGFVAQTS 660 RSHEPYLKSW AQELGAPIIS IDYSLAPEAP FPRALEECFF AYCWAIKHCA LLGSTGERIC 720 LAGDSAGGNL CFTVALRAAA YGVRVPDGIM AAYPATMLQP AASPSRLLSL MDPLLPLSVL 780 SKCVSAYAGA KTEDHSNSDQ KALGMMGLVR RDTALLLRDF RLGASSWLNS FLELSGRKSQ 840 KMSEPIAEPM RRSVSEAALA QPQGPLGTDS LKNLTLRDLS LRGNSETSSD TPEMSLSAET 900 LSPSTPSDVN FLLPPEDAGE EAEAKNELSP MDRGLGVRAA FPEGFHPRRS SQGATQMPLY 960 SSPIVKNPFM SPLLAPDSML KSLPPVHIVA CALDPMLDDS VMLARRLRNL GQPVTLRVVE 1020 DLPHGFLTLA ALCRETRQAA ELCVERIRLV LTPPAGAGPS GETGAAGVDG GCGGRH 1077 Fasta Sequence >Q05469\|LIPE\|Homo sapiens (Human) MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQQETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLGKESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQETPEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGSSSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIHNMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKAFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLSKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVEDLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH

※ PTM-Disease Association

Num	PTM	Disease	Type	PTM Site	PMID
1	Serine Phosphorylation	Obesity	D	S853	18398140
1	[Reference]: Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation.
2	Serine Phosphorylation	Obesity	D	S950	18398140
2	[Reference]: Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 1)	MESH:D052496 ; Lipodystrophy, Familial Partial
DisGeNet (Curated) (count: 28) (view all)	C0000889; Acanthosis Nigricans C0019209; Hepatomegaly C0021655; Insulin Resistance C0023787; Lipodystrophy C0028949; Oligomenorrhea C0032460; Polycystic Ovary Syndrome C0151576; Elevated creatine kinase C0241005; Creatine phosphokinase serum increased C0242339; Dyslipidemias C0311277; Obesity, Abdominal C0854110; Insulin resistant diabetes C1136382; Sclerocystic Ovaries C1522137; Hypertriglyceridemia result C1835390; Increased intraabdominal fat C1837764; Loss of subcutaneous adipose tissue in limbs C1837802; Decreased serum leptin C1846013; Marked muscular hypertrophy C1866010; Proximal muscle weakness in lower limbs C1866012; Proximal muscle weakness in upper limbs C2711227; Steatohepatitis C2712907; combined hyperlipidemia C4014869; LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 6 C4020899; Autosomal recessive predisposition C4022695; Abnormality of the labia majora C4024606; Loss of gluteal subcutaneous adipose tissue C4025650; Abnormality of lipid metabolism C4025850; Increased adipose tissue around the neck C4073127; Decreased adiponectin level
GWASdb (count: 1)	rs34052647; LDL cholesterol; atherosclerosis\|coronary artery disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 14) (view all)	1015 RNLGQPVTLRVVEDL dbPAF 188 PEQSDKQTTPVQGAK dbPAF 189 EQSDKQTTPVQGAKS dbPAF 196 TPVQGAKSKQGSLTE dbPAF 565 ASATVRVSRLLSLPP dbPAF 645 QQAPRSRSLIVHFHG dbPAF 741 VALRAAAYGVRVPDG dbPAF 853 IAEPMRRSVSEAALA dbPAF 855 EPMRRSVSEAALAQP dbPAF 891 NSETSSDTPEMSLSA dbPAF 950 EGFHPRRSSQGATQM dbPAF 951 GFHPRRSSQGATQMP dbPAF 955 RRSSQGATQMPLYSS dbPAF 960 GATQMPLYSSPIVKN dbPAF
Ubiquitination (count: 1)	624 EELSSLIKSNGQRSL PLMD

PTM

Modification Sites

Phosphorylation
(count: 14)
(view all)

1015      RNLGQPVTLRVVEDL     dbPAF
188       PEQSDKQTTPVQGAK     dbPAF
189       EQSDKQTTPVQGAKS     dbPAF
196       TPVQGAKSKQGSLTE     dbPAF
565       ASATVRVSRLLSLPP     dbPAF
645       QQAPRSRSLIVHFHG     dbPAF

Ubiquitination
(count: 1)

624 EELSSLIKSNGQRSL PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

P27361	Q05469	HPRD
P28482	Q05469	HPRD

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction