Tag | Content |
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UniProt Accession | FAK1_HUMAN; Q05397; |
Entrez ID | 5747 |
GenBank Protein ID | NM_001199649.1; NM_153831.3; XM_017013673.1; |
GenBank Nucleotide ID | NP_001186578.1; NP_722560.1; XP_016869162.1; |
Protein Name | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) |
Gene Name | PTK2; FAK; FAK1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse form(view all) |
Sequence (Fasta) | MAAAYLDPNL NHTPNSSTKT HLGTGMERSP GAMERVLKVF HYFESNSEPT TWASIIRHGD 60 ATDVRGIIQK IVDSHKVKHV ACYGFRLSHL RSEEVHWLHV DMGVSSVREK YELAHPPEEW 120 KYELRIRYLP KGFLNQFTED KPTLNFFYQQ VKSDYMLEIA DQVDQEIALK LGCLEIRRSY 180 WEMRGNALEK KSNYEVLEKD VGLKRFFPKS LLDSVKAKTL RKLIQQTFRQ FANLNREESI 240 LKFFEILSPV YRFDKECFKC ALGSSWIISV ELAIGPEEGI SYLTDKGCNP THLADFTQVQ 300 TIQYSNSEDK DRKGMLQLKI AGAPEPLTVT APSLTIAENM ADLIDGYCRL VNGTSQSFII 360 RPQKEGERAL PSIPKLANSE KQGMRTHAVS VSETDDYAEI IDEEDTYTMP STRDYEIQRE 420 RIELGRCIGE GQFGDVHQGI YMSPENPALA VAIKTCKNCT SDSVREKFLQ EALTMRQFDH 480 PHIVKLIGVI TENPVWIIME LCTLGELRSF LQVRKYSLDL ASLILYAYQL STALAYLESK 540 RFVHRDIAAR NVLVSSNDCV KLGDFGLSRY MEDSTYYKAS KGKLPIKWMA PESINFRRFT 600 SASDVWMFGV CMWEILMHGV KPFQGVKNND VIGRIENGER LPMPPNCPPT LYSLMTKCWA 660 YDPSRRPRFT ELKAQLSTIL EEEKAQQEER MRMESRRQAT VSWDSGGSDE APPKPSRPGY 720 PSPRSSEGFY PSPQHMVQTN HYQVSGYPGS HGITAMAGSI YPGQASLLDQ TDSWNHRPQE 780 IAMWQPNVED STVLDLRGIG QVLPTHLMEE RLIRQQQEME EDQRWLEKEE RFLKPDVRLS 840 RGSIDREDGS LQGPIGNQHI YQPVGKPDPA APPKKPPRPG APGHLGSLAS LSSPADSYNE 900 GVKLQPQEIS PPPTANLDRS NDKVYENVTG LVKAVIEMSS KIQPAPPEEY VPMVKEVGLA 960 LRTLLATVDE TIPLLPASTH REIEMAQKLL NSDLGELINK MKLAQQYVMT SLQQEYKKQM 1020 LTAAHALAVD AKNLLDVIDQ ARLKMLGQTR PH 1053 |
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Database | Annotation |
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CTD (Curated) (count: 8) (view all) | MESH:D001172
; Arthritis, Rheumatoid MESH:D006528 ; Carcinoma, Hepatocellular MESH:D002294 ; Carcinoma, Squamous Cell MESH:D002471 ; Cell Transformation, Neoplastic MESH:D005909 ; Glioblastoma MESH:D008325 ; Mammary Neoplasms, Experimental |
GWASdb (count: 33) (view all) | rs10088475; Brain structure; Alzheimer's disease
rs13273096; Brain structure; Alzheimer's disease rs7016497; Multiple complex diseases; Null rs11166992; Brain structure; Alzheimer's disease rs3639; Brain structure; Alzheimer's disease rs4413752; Brain structure; Alzheimer's disease |
PTM | Modification Sites |
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Phosphorylation (count: 67) (view all) | 1007 KMKLAQQYVMTSLQQ dbPAF
1016 MTSLQQEYKKQMLTA dbPAF 13 LDPNLNHTPNSSTKT dbPAF 148 KPTLNFFYQQVKSDY dbPAF 155 YQQVKSDYMLEIADQ dbPAF 16 NLNHTPNSSTKTHLG dbPAF |
Sumoylation (count: 1) | 152 NFFYQQVKSDYMLEI PLMD |
Malonylation (count: 1) | 222 VKAKTLRKLIQQTFR PLMD |