Tag | Content |
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UniProt Accession | KPCT_HUMAN; Q04759; |
Entrez ID | 5588 |
GenBank Protein ID | NM_001242413.2; NM_001282644.1; NM_001282645.1; NM_001323265.1; NM_001323266.1; NM_006257.4; XM_006717465.3; XM_017016410.1; XM_017016411.1; |
GenBank Nucleotide ID | NP_001229342.1; NP_001269573.1; NP_001269574.1; NP_001310194.1; NP_001310195.1; NP_006248.1; XP_006717528.1; XP_016871899.1; XP_016871900.1; |
Protein Name | Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) |
Gene Name | PRKCQ; PRKCT |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFA(view all) |
Sequence (Fasta) | MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP TMYPPWDSTF 60 DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN GKTEIWLELK PQGRMLMNAR 120 YFLEMSDTKD MNEFETEGFF ALHQRRGAIK QAKVHHVKCH EFTATFFPQP TFCSVCHEFV 180 WGLNKQGYQC RQCNAAIHKK CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK 240 SPTFCEHCGT LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ 300 ARCLRDTEQI FREGPVEIGL PCSIKNEARP PCLPTPGKRE PQGISWESPL DEVDKMCHLP 360 EPELNKERPS LQIKLKIEDF ILHKMLGKGS FGKVFLAEFK KTNQFFAIKA LKKDVVLMDD 420 DVECTMVEKR VLSLAWEHPF LTHMFCTFQT KENLFFVMEY LNGGDLMYHI QSCHKFDLSR 480 ATFYAAEIIL GLQFLHSKGI VYRDLKLDNI LLDKDGHIKI ADFGMCKENM LGDAKTNTFC 540 GTPDYIAPEI LLGQKYNHSV DWWSFGVLLY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR 600 WLEKEAKDLL VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP FRPKVKSPFD 660 CSNFDKEFLN EKPRLSFADR ALINSMDQNM FRNFSFMNPG MERLIS 707 |
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Database | Annotation |
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CTD (Curated) (count: 5) | MESH:D020261
; Arsenic Poisoning MESH:D001172 ; Arthritis, Rheumatoid MESH:D003922 ; Diabetes Mellitus, Type 1 MESH:D016410 ; Lymphoma, T-Cell, Cutaneous MESH:D012163 ; Retinal Detachment |
GWASdb (count: 34) (view all) | rs4750439; Suicide attempts in bipolar disorder; bipolar disorder
rs2236380; Suicide attempts in bipolar disorder; bipolar disorder rs2236380; Type 1 diabetes; type 1 diabetes mellitus rs681023; Multiple complex diseases; Null rs11596750; Suicide attempts in bipolar disorder; bipolar disorder rs11258747; Type 1 diabetes; type 1 diabetes mellitus |
PTM | Modification Sites |
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Phosphorylation (count: 19) (view all) | 121 RMLMNARYFLEMSDT dbPAF
219 SAINSRETMFHKERF dbPAF 275 NVHHRCQTKVANLCG dbPAF 28 QGEAVNPYCAVLVKE dbPAF 307 QARCLRDTEQIFREG dbPAF 323 VEIGLPCSIKNEARP dbPAF |
Acetylation (count: 4) | 208 CIDKVIAKCTGSAIN PLMD
338 PCLPTPGKREPQGIS PLMD 384 IEDFILHKMLGKGSF PLMD 607 RWLEKEAKDLLVKLF PLMD |
Ubiquitination (count: 26) (view all) | 110 TEIWLELKPQGRMLM PLMD
208 CIDKVIAKCTGSAIN PLMD 223 SRETMFHKERFKIDM PLMD 227 MFHKERFKIDMPHRF PLMD 235 IDMPHRFKVYNYKSP PLMD 240 RFKVYNYKSPTFCEH PLMD |
Network | Interaction | ||
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A | B | Source | |