Tag | Content |
---|---|
UniProt Accession | TF65_HUMAN; Q04206; |
Entrez ID | 5970 |
GenBank Protein ID | NM_001145138.1; NM_001243984.1; NM_021975.3; |
GenBank Nucleotide ID | NP_001138610.1; NP_001230913.1; NP_068810.3; |
Protein Name | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) |
Gene Name | RELA; NFKB3 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dim(view all) |
Sequence (Fasta) | MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER STDTTKTHPT 60 IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY EAELCPDRCI HSFQNLGIQC 120 VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG DYDLNAVRLC FQVTVRDPSG RPLRLPPVLS 180 HPIFDNRAPN TAELKICRVN RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS 240 QADVHRQVAI VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE 300 KRKRTYETFK SIMKKSPFSG PTDPRPPPRR IAVPSRSSAS VPKPAPQPYP FTSSLSTINY 360 DEFPTMVFPS GQISQASALA PAPPQVLPQA PAPAPAPAMV SALAQAPAPV PVLAPGPPQA 420 VAPPAPKPTQ AGEGTLSEAL LQLQFDDEDL GALLGNSTDP AVFTDLASVD NSEFQQLLNQ 480 GIPVAPHTTE PMLMEYPEAI TRLVTGAQRP PDPAPAPLGA PGLPNGLLSG DEDFSSIADM 540 DFSALLSQIS S 552 |
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Database | Annotation |
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CTD (Curated) (count: 26) (view all) | MESH:D019969
; Amphetamine-Related Disorders MESH:D001471 ; Barrett Esophagus MESH:D002545 ; Brain Ischemia MESH:D001932 ; Brain Neoplasms MESH:D001943 ; Breast Neoplasms MESH:D002292 ; Carcinoma, Renal Cell |
GWASdb (count: 1) | rs1049728; Soluble ICAM-1; fatty liver disease|myocardial infarction |
PTM | Modification Sites |
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Phosphorylation (count: 22) (view all) | 131 RDLEQAISQRIQTNN dbPAF
205 RVNRNSGSCLGGDEI dbPAF 238 PGWEARGSFSQADVH dbPAF 254 QVAIVFRTPPYADPS dbPAF 276 SMQLRRPSDRELSEP dbPAF 281 RPSDRELSEPMEFQY dbPAF |
Acetylation (count: 9) (view all) | 122 NLGIQCVKKRDLEQA PLMD
123 LGIQCVKKRDLEQAI PLMD 195 APNTAELKICRVNRN PLMD 218 EIFLLCDKVQKEDIE PLMD 221 LLCDKVQKEDIEVYF PLMD 310 KRTYETFKSIMKKSP PLMD |
Ubiquitination (count: 2) | 195 APNTAELKICRVNRN PLMD
310 KRTYETFKSIMKKSP PLMD |
Malonylation (count: 2) | 122 NLGIQCVKKRDLEQA PLMD
62 TKTHPTIKINGYTGP PLMD |
Methylation (count: 6) | 218 EIFLLCDKVQKEDIE PLMD
221 LLCDKVQKEDIEVYF PLMD 310 KRTYETFKSIMKKSP PLMD 314 ETFKSIMKKSPFSGP PLMD 315 TFKSIMKKSPFSGPT PLMD 37 RGMRFRYKCEGRSAG PLMD |