| Tag | Content |
|---|---|
| UniProt Accession | CAV1_HUMAN; Q03135; |
| Entrez ID | 857 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Caveolin-1 |
| Gene Name | CAV1; CAV |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). |
| Sequence (Fasta) | MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADELSEKQ VYDAHTKEID LVNRDPKHLN 60 DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSALFGIP MALIWGIYFA 120 ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTVCDPLF EAVGKIFSNV RINLQKEI 179 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 17) (view all) | MESH:D001281
; Atrial Fibrillation MESH:D001943 ; Breast Neoplasms MESH:D006332 ; Cardiomegaly MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D065627 ; Familial Primary Pulmonary Hypertension MESH:D005902 ; Glaucoma, Open-Angle |
| HGMD (count: 3) | CD082074; Lipodystrophy, partial, atypical; Small deletions
CD082075; Lipodystrophy, partial, atypical; Small deletions CM081202; Berardinelli-Seip lipodystrophy; Missense/nonsense |
| GWASdb (count: 10) (view all) | rs3807986; Suicide attempts in bipolar disorder; bipolar disorder
rs3807989; PR interval; heart conduction disease rs3807989; Electrocardiographic traits; heart conduction disease rs3807989; Atrial fibrillation; familial atrial fibrillation rs3807989; PR segment; familial atrial fibrillation rs3815412; Suicide attempts in bipolar disorder; bipolar disorder |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 14) (view all) | 14 VDSEGHLYTVPIREQ dbPAF
15 DSEGHLYTVPIREQG dbPAF 168 EAVGKIFSNVRINLQ dbPAF 2 ******MSGGKYVDS dbPAF 25 IREQGNIYKPNNKAM dbPAF 37 KAMADELSEKQVYDA dbPAF |
| Acetylation (count: 3) | 39 MADELSEKQVYDAHT PLMD
5 ***MSGGKYVDSEGH PLMD 57 DLVNRDPKHLNDDVV PLMD |
| Ubiquitination (count: 8) (view all) | 176 NVRINLQKEI***** PLMD
26 REQGNIYKPNNKAMA PLMD 30 NIYKPNNKAMADELS PLMD 39 MADELSEKQVYDAHT PLMD 47 QVYDAHTKEIDLVNR PLMD 5 ***MSGGKYVDSEGH PLMD |
| Sumoylation (count: 1) | 5 ***MSGGKYVDSEGH PLMD |
| Malonylation (count: 1) | 5 ***MSGGKYVDSEGH PLMD |