Q03060

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession CREM_HUMAN; Q03060;
Entrez ID 1390
GenBank Protein ID NM_001267562.1; NM_001267564.1; NM_001267567.1; NM_001267570.1; NM_001881.3; NM_181571.2; NM_182717.1; NM_182718.1; NM_182719.1; NM_182720.1; NM_182721.1; NM_182723.1; NM_182724.1; NM_182769.2; NM_182770.2; NM_182771.1; NM_182772.1; NM_183011.1; NM_183012.1; NM_183013.2; NM_183060.2; XM_006717378.3; XM_006717379.3; XM_006717382.3; XM_006717383.3; XM_011519316.2; XM_011519324.2; XM_011519325.2; XM_017015722.1;
GenBank Nucleotide ID NP_001254491.1; NP_001254493.1; NP_001254496.1; NP_001254499.1; NP_001872.3; NP_853549.1; NP_874386.1; NP_874387.1; NP_874388.1; NP_874389.1; NP_874390.1; NP_874392.1; NP_874393.1; NP_877570.1; NP_877571.1; NP_877572.1; NP_877573.1; NP_898829.1; NP_898830.1; NP_898831.1; NP_898883.1; XP_006717441.1; XP_006717442.1; XP_006717445.1; XP_006717446.1; XP_011517618.1; XP_011517626.1; XP_011517627.1; XP_016871211.1;
Protein Name cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER)
Gene Name CREM
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTranscriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).;Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
Sequence
(Fasta)		MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVSVA 60
GSGTRRGSPA VTLVQLPSGQ TIHVQGVIQT PQPWVIQSSE IHTVQVAAIA ETDESAESEG 120
VIDSHKRREI LSRRPSYRKI LNELSSDVPG VPKIEEERSE EEGTPPSIAT MAVPTSIYQT 180
STGQYIAIAQ GGTIQISNPG SDGVQGLQAL TMTNSGAPPP GATIVQYAAQ SADGTQQFFV 240
PGSQVVVQDE ETELAPSHMA AATGDMPTYQ IRAPTAALPQ GVVMAASPGS LHSPQQLAEE 300
ATRKRELRLM KNREAAKECR RRKKEYVKCL ESRVAVLEVQ NKKLIEELET LKDICSPKTD 360
Y 362

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1UbiquitinationChoriocarcinomaU11466319
[Reference]: This alteration in stability was due to the inability of the Ser-41-mutant ICER to be efficiently ubiquitinated and degraded via the ubiquitin-proteasome pathway.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 6)		MESH:D001171 ; Arthritis, Juvenile
MESH:D054506 ; Chloracne
MESH:D017449 ; Dermatitis, Allergic Contact
MESH:D003925 ; Diabetic Angiopathies
MESH:D006984 ; Hypertrophy
MESH:D009203 ; Myocardial Infarction
DisGeNet (Curated)
(count: 10)
(view all)		C0005586; Bipolar Disorder
C0011875; Diabetic Angiopathies
C0020564; Hypertrophy
C0027051; Myocardial Infarction
C0036341; Schizophrenia
C0041696; Unipolar Depression
GWASdb
(count: 7)
(view all)		rs10827492; Parkinson's disease; Parkinson's disease
rs12761675; Multiple complex diseases; Null
rs2505639; Multiple complex diseases; Null
rs4934540; Parkinson's disease; Parkinson's disease
rs7077242; Multiple complex diseases; Null
rs4934735; Multiple complex diseases; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 20)
(view all)		 112       QVAAIAETDESAESE     dbPAF
115       AIAETDESAESEGVI     dbPAF
124       ESEGVIDSHKRREIL     dbPAF
132       HKRREILSRRPSYRK     dbPAF
136       EILSRRPSYRKILNE     dbPAF
137       ILSRRPSYRKILNEL     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource