Tag | Content |
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UniProt Accession | MP2K1_HUMAN; Q02750; |
Entrez ID | 5604 |
GenBank Protein ID | NM_002755.3; XM_017022411.1; |
GenBank Nucleotide ID | NP_002746.1; XP_016877900.1; |
Protein Name | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) |
Gene Name | MAP2K1; MEK1; PRKMK1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Ty(view all) |
Sequence (Fasta) | MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV 60 GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE 120 CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL 180 REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY 240 SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELMFGCQVE GDAAETPPRP RTPGRPLSSY 300 GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF 360 IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA AGV 394 |
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Database | Annotation |
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Cancer Gene Census | NSCLC, melanoma, colorectal |
CTD (Curated) (count: 7) (view all) | MESH:C538231
; Adenocarcinoma of lung MESH:D002545 ; Brain Ischemia MESH:C535579 ; Cardiofaciocutaneous syndrome MESH:D056685 ; Costello Syndrome MESH:D007943 ; Leukemia, Hairy Cell MESH:D008545 ; Melanoma |
HGMD (count: 13) (view all) | CD073663; Cardio-facio-cutaneous syndrome; Small deletions
CM092997; Cardio-facio-cutaneous syndrome; Missense/nonsense CM076270; Noonan syndrome ?; Missense/nonsense CM061105; Cardio-facio-cutaneous syndrome; Missense/nonsense CM076271; Costello syndrome; Missense/nonsense CM076269; Cardio-facio-cutaneous syndrome; Missense/nonsense |
GWASdb (count: 11) (view all) | rs11854215; Sarcoidosis; sarcoidosis
rs61027991; Sarcoidosis; sarcoidosis rs34957511; Sarcoidosis; sarcoidosis rs12909274; Sarcoidosis; sarcoidosis rs11633875; Sarcoidosis; sarcoidosis rs540311027; Sarcoidosis; sarcoidosis |
PTM | Modification Sites |
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Phosphorylation (count: 20) (view all) | 212 KLCDFGVSGQLIDSM dbPAF
218 VSGQLIDSMANSFVG dbPAF 222 LIDSMANSFVGTRSY dbPAF 226 MANSFVGTRSYMSPE dbPAF 23 DGSAVNGTSSAETNL dbPAF 231 VGTRSYMSPERLQGT dbPAF |
Acetylation (count: 2) | 353 PAERADLKQLMVHAF PLMD
64 KQKVGELKDDDFEKI PLMD |
Ubiquitination (count: 10) (view all) | 168 IPEQILGKVSIAVIK PLMD
175 KVSIAVIKGLTYLRE PLMD 192 KIMHRDVKPSNILVN PLMD 269 PIPPPDAKELELMFG PLMD 353 PAERADLKQLMVHAF PLMD 36 NLEALQKKLEELELD PLMD |
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