Q02446

※ Protein Information

Tag	Content
UniProt Accession	SP4_HUMAN; Q02446;
Entrez ID	6671
GenBank Protein ID	NM_001326543.1; NM_003112.4;
GenBank Nucleotide ID	NP_001313472.1; NP_003103.2;
Protein Name	Transcription factor Sp4 (SPR-1)
Gene Name	SP4
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Binds to GT and GC boxes promoters elements. Probable transcriptional activator. Functional Description Binds to GT and GC boxes promoters elements. Probable transcriptional activator.
Sequence (Fasta)	MSDQKKEEEE EAAAAAAMAT EGGKTSEPEN NNKKPKTSGS QDSQPSPLAL LAATCSKIGT 60 PGENQATGQQ QIIIDPSQGL VQLQNQPQQL ELVTTQLAGN AWQLVASTPP ASKENNVSQP 120 ASSSSSSSSS NNGSASPTKT KSGNSSTPGQ FQVIQVQNPS GSVQYQVIPQ LQTVEGQQIQ 180 INPTSSSSLQ DLQGQIQLIS AGNNQAILTA ANRTASGNIL AQNLANQTVP VQIRPGVSIP 240 LQLQTLPGTQ AQVVTTLPIN IGGVTLALPV INNVAAGGGT GQVGQPAATA DSGTSNGNQL 300 VSTPTNTTTS ASTMPESPSS STTCTTTAST SLTSSDTLVS SADTGQYAST SASSSERTIE 360 ESQTPAATES EAQSSSQLQP NGMQNAQDQS NSLQQVQIVG QPILQQIQIQ QPQQQIIQAI 420 PPQSFQLQSG QTIQTIQQQP LQNVQLQAVN PTQVLIRAPT LTPSGQISWQ TVQVQNIQSL 480 SNLQVQNAGL SQQLTITPVS SSGGTTLAQI APVAVAGAPI TLNTAQLASV PNLQTVSVAN 540 LGAAGVQVQG VPVTITSVAG QQQGQDGVKV QQATIAPVTV AVGGIANATI GAVSPDQLTQ 600 VHLQQGQQTS DQEVQPGKRL RRVACSCPNC REGEGRGSNE PGKKKQHICH IEGCGKVYGK 660 TSHLRAHLRW HTGERPFICN WMFCGKRFTR SDELQRHRRT HTGEKRFECP ECSKRFMRSD 720 HLSKHVKTHQ NKKGGGTALA IVTSGELDSS VTEVLGSPRI VTVAAISQDS NPATPNVSTN 780 MEEF 785 Fasta Sequence >Q02446\|SP4\|Homo sapiens (Human) MSDQKKEEEEEAAAAAAMATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGTPGENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQPASSSSSSSSSNNGSASPTKTKSGNSSTPGQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQINPTSSSSLQDLQGQIQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALPVINNVAAGGGTGQVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPESPSSSTTCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIEESQTPAATESEAQSSSQLQPNGMQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQLQAVNPTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDQEVQPGKRLRRVACSCPNCREGEGRGSNEPGKKKQHICHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF

※ PTM-Disease Association

Num	PTM	Disease	Type	PTM Site	PMID
1	Serine Phosphorylation	Schizophrenia	U	S770	26049820
1	[Reference]: Our results indicate that SP4 S770 phosphorylation is increased in the cerebellum in bipolar disorder subjects that committed suicide and in severe schizophrenia subjects, and may be part of a degradation signal that controls Sp4 abundance in cerebellar granule neurons.
2	Serine Phosphorylation	Bipolar disorder	U	S770	26049820
2	[Reference]: Our results indicate that SP4 S770 phosphorylation is increased in the cerebellum in bipolar disorder subjects that committed suicide and in severe schizophrenia subjects, and may be part of a degradation signal that controls Sp4 abundance in cerebellar granule neurons.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 2)	MESH:D001714 ; Bipolar Disorder MESH:D012559 ; Schizophrenia
GWASdb (count: 20) (view all)	rs7795411; Major depressive disorder (broad); major depressive disorder rs2282887; Major depressive disorder (broad); major depressive disorder rs757429; Fibrinogen; cardiovascular system disease rs2107449; Acute lymphoblastic leukemia (B-cell precursor); acute lymphocytic leukemia\|acute leukemia rs10233357; Major depressive disorder (broad); major depressive disorder rs2282890; Body mass index; obesity rs10950853; Major depressive disorder (broad); major depressive disorder rs7793276; Major depressive disorder (broad); major depressive disorder rs12672607; Major depressive disorder (broad); major depressive disorder rs3807644; Major depressive disorder (broad); major depressive disorder rs17144465; Major depressive disorder (broad); major depressive disorder rs17144465; Major depressive disorder; major depressive disorder rs10235984; Major depressive disorder (broad); major depressive disorder rs2282896; Major depressive disorder (broad); major depressive disorder rs3807641; Major depressive disorder (broad); major depressive disorder rs7811417; Hypertension; hypertension rs12674215; Major depressive disorder (broad); major depressive disorder rs2390538; Acute lymphoblastic leukemia (B-cell precursor); acute lymphocytic leukemia\|acute leukemia rs2390538; Response to cytadine analogues (cytosine arabinoside); cancer rs3823777; Major depressive disorder (broad); major depressive disorder

Database

Annotation

CTD (Curated)
(count: 2)

MESH:D001714 ; Bipolar Disorder
MESH:D012559 ; Schizophrenia

GWASdb
(count: 20)
(view all)

rs7795411; Major depressive disorder (broad); major depressive disorder
rs2282887; Major depressive disorder (broad); major depressive disorder
rs757429; Fibrinogen; cardiovascular system disease
rs2107449; Acute lymphoblastic leukemia (B-cell precursor); acute lymphocytic leukemia|acute leukemia
rs10233357; Major depressive disorder (broad); major depressive disorder
rs2282890; Body mass index; obesity

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 24) (view all)	108 AWQLVASTPPASKEN dbPAF 124 VSQPASSSSSSSSSN dbPAF 125 SQPASSSSSSSSSNN dbPAF 126 QPASSSSSSSSSNNG dbPAF 127 PASSSSSSSSSNNGS dbPAF 129 SSSSSSSSSNNGSAS dbPAF 130 SSSSSSSSNNGSASP dbPAF 134 SSSSNNGSASPTKTK dbPAF 136 SSNNGSASPTKTKSG dbPAF 138 NNGSASPTKTKSGNS dbPAF 20 AAAAAMATEGGKTSE dbPAF 37 NNNKKPKTSGSQDSQ dbPAF 38 NNKKPKTSGSQDSQP dbPAF 40 KKPKTSGSQDSQPSP dbPAF 46 GSQDSQPSPLALLAA dbPAF 609 HLQQGQQTSDQEVQP dbPAF 672 RAHLRWHTGERPFIC dbPAF 691 CGKRFTRSDELQRHR dbPAF 700 ELQRHRRTHTGEKRF dbPAF 702 QRHRRTHTGEKRFEC dbPAF 767 IVTVAAISQDSNPAT dbPAF 770 VAAISQDSNPATPNV dbPAF 774 SQDSNPATPNVSTNM dbPAF 778 NPATPNVSTNMEEF* dbPAF

PTM

Modification Sites

Phosphorylation
(count: 24)
(view all)

108       AWQLVASTPPASKEN     dbPAF
124       VSQPASSSSSSSSSN     dbPAF
125       SQPASSSSSSSSSNN     dbPAF
126       QPASSSSSSSSSNNG     dbPAF
127       PASSSSSSSSSNNGS     dbPAF
129       SSSSSSSSSNNGSAS     dbPAF

※ Protein-Protein Interaction

Network

Interaction

Source

P08047	Q02446	HPRD
P16104	Q02446	BioGRID
Q01094	Q02446	HPRD

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction