Q02156

※ Protein Information

Tag	Content
UniProt Accession	KPCE_HUMAN; Q02156;
Entrez ID	5581
GenBank Protein ID	NM_005400.2; XM_005264428.1;
GenBank Nucleotide ID	NP_005391.1; XP_005264485.1;
Protein Name	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon)
Gene Name	PRKCE; PKCE
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integ(view all) Functional Description Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.
Sequence (Fasta)	MVVFNGLLKI KICEAVSLKP TAWSLRHAVG PRPQTFLLDP YIALNVDDSR IGQTATKQKT 60 NSPAWHDEFV TDVCNGRKIE LAVFHDAPIG YDDFVANCTI QFEELLQNGS RHFEDWIDLE 120 PEGRVYVIID LSGSSGEAPK DNEERVFRER MRPRKRQGAV RRRVHQVNGH KFMATYLRQP 180 TYCSHCRDFI WGVIGKQGYQ CQVCTCVVHK RCHELIITKC AGLKKQETPD QVGSQRFSVN 240 MPHKFGIHNY KVPTFCDHCG SLLWGLLRQG LQCKVCKMNV HRRCETNVAP NCGVDARGIA 300 KVLADLGVTP DKITNSGQRR KKLIAGAESP QPASGSSPSE EDRSKSAPTS PCDQEIKELE 360 NNIRKALSFD NRGEEHRAAS SPDGQLMSPG ENGEVRQGQA KRLGLDEFNF IKVLGKGSFG 420 KVMLAELKGK DEVYAVKVLK KDVILQDDDV DCTMTEKRIL ALARKHPYLT QLYCCFQTKD 480 RLFFVMEYVN GGDLMFQIQR SRKFDEPRSR FYAAEVTSAL MFLHQHGVIY RDLKLDNILL 540 DAEGHCKLAD FGMCKEGILN GVTTTTFCGT PDYIAPEILQ ELEYGPSVDW WALGVLMYEM 600 MAGQPPFEAD NEDDLFESIL HDDVLYPVWL SKEAVSILKA FMTKNPHKRL GCVASQNGED 660 AIKQHPFFKE IDWVLLEQKK IKPPFKPRIK TKRDVNNFDQ DFTREEPVLT LVDEAIVKQI 720 NQEEFKGFSY FGEDLMP 738 Fasta Sequence >Q02156\|PRKCE; PKCE\|Homo sapiens (Human) MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Phosphorylation	Glioblastoma		U		15153340
1	[Reference]: In human U87MG glioblastoma cells, AChE-R formed a triple complex with protein kinase C (PKC) epsilon and the scaffold protein RACK1, enhanced PKCepsilon phosphorylation, and facilitated BrdU incorporation.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 11) (view all)	MESH:D009202 ; Cardiomyopathies MESH:D015179 ; Colorectal Neoplasms MESH:D023921 ; Coronary Stenosis MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D003928 ; Diabetic Nephropathies MESH:D006930 ; Hyperalgesia MESH:D008113 ; Liver Neoplasms MESH:D009203 ; Myocardial Infarction MESH:D017202 ; Myocardial Ischemia MESH:D010523 ; Peripheral Nervous System Diseases MESH:D019966 ; Substance-Related Disorders
GWASdb (count: 135) (view all)	rs3731949; Myopia (pathological); myopia rs542413; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension rs11674329; Hypertension (early onset hypertension); hypertension rs6743119; Type 2 diabetes; type 2 diabetes mellitus rs4953246; Obesity (extreme); obesity rs938661; Urinary metabolites; kidney disease rs867286; Bipolar disorder and schizophrenia; bipolar disorder\|schizophrenia rs867286; Obesity (extreme); obesity rs884401; Obesity (extreme); obesity rs884400; Urinary metabolites; kidney disease rs884399; Obesity (extreme); obesity rs4953249; Major depression (suicidal thoughts and behavior); major depressive disorder rs4953251; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension rs3924521; Breast cancer; breast cancer rs3924523; Rheumatoid Arthritis (Cyclic citrullinated peptide positive); rheumatoid arthritis rs13404973; Autism spectrum disorders (language delay); autism spectrum disorder rs13405086; Autism spectrum disorders (language delay); autism spectrum disorder rs7558342; Serum metabolites; Null rs11898074; Response to cholinesterase inhibitors in Alzheimer's disease; Alzheimer's disease rs11898209; Hypothyroidism; hypothyroidism rs6743144; Urinary metabolites; kidney disease rs4953260; Hypothyroidism; hypothyroidism rs7593800; Biliary atresia; biliary atresia rs3886870; Hypertension; hypertension rs935672; Type 2 diabetes; type 2 diabetes mellitus rs12328510; Parkinson's disease (age of onset); Parkinson's disease rs6747706; Alzheimer's disease (age of onset); Alzheimer's disease rs13409215; Alzheimer's disease (age of onset); Alzheimer's disease rs935661; Type 2 diabetes and 6 quantitative traits; type 2 diabetes mellitus rs10865208; Type 2 diabetes; type 2 diabetes mellitus rs935656; Coronary Artery Disease; coronary artery disease rs7593255; Multiple complex diseases; Null rs1947195; Alzheimer's disease (age of onset); Alzheimer's disease rs1992932; Progressive supranuclear palsy; progressive supranuclear palsy rs10189339; Progressive supranuclear palsy; progressive supranuclear palsy rs12467641; Suicide attempts in bipolar disorder; bipolar disorder rs11125041; Suicide attempts in bipolar disorder; bipolar disorder rs13431763; Suicide attempts in bipolar disorder; bipolar disorder rs878812; Multiple complex diseases; Null rs13417518; Left ventricular mass; hypertension rs6720958; Urinary metabolites; kidney disease rs13036100; Multiple complex diseases; Null rs13023787; Smoking initiation; nicotine dependence rs11903566; Normoxic and mild-hypoxic adaptation in populations residing at low and moderate altitudes; asthma\|chronic obstructive pulmonary disease rs6750700; Body mass index; obesity rs6751349; QT interval; heart conduction disease\|long QT syndrome rs12471357; Response to tocilizumab in rheumatoid arthritis; rheumatoid arthritis rs2595199; Lung function (forced expiratory volume in 1 second to forced vital capacity ratio); lung disease rs7607360; Cognitive impairment induced by topiramate; cognitive disorder rs13396424; Metabolite levels (X-11787); atherosclerosis\|congestive heart failure rs2595211; Nicotine dependence; nicotine dependence rs6705717; Type 2 diabetes; type 2 diabetes mellitus rs2122112; Cognitive performance; cognitive disorder rs11903923; Rheumatoid arthritis; rheumatoid arthritis rs1470598; Nicotine smoking; nicotine dependence rs6751805; Blood pressure; hypertension rs12712962; Response to cytidine analogues (gemcitabine); cancer rs12712963; Multiple complex diseases; Null rs12712963; Response to cytidine analogues (gemcitabine); cancer rs12712963; Response to cytadine analogues (cytosine arabinoside); cancer rs13432276; Gaucher disease severity; Gaucher's disease rs2345955; Nicotine smoking; nicotine dependence rs2345955; Suicide attempts in bipolar disorder; bipolar disorder rs12373805; Suicide attempts in bipolar disorder; bipolar disorder rs10167555; Suicide attempts in bipolar disorder; bipolar disorder rs10202504; Suicide attempts in bipolar disorder; bipolar disorder rs4953309; Suicide attempts in bipolar disorder; bipolar disorder rs12477342; Suicide attempts in bipolar disorder; bipolar disorder rs12477409; Suicide attempts in bipolar disorder; bipolar disorder rs7568264; Suicide attempts in bipolar disorder; bipolar disorder rs1116246; Suicide attempts in bipolar disorder; bipolar disorder rs12712969; Suicide attempts in bipolar disorder; bipolar disorder rs12712969; Pulmonary function decline; chronic obstructive pulmonary disease\|asthma rs12712970; Suicide attempts in bipolar disorder; bipolar disorder rs11680282; Body mass index; obesity rs11684352; Body mass index; obesity rs1597156; Suicide attempts in bipolar disorder; bipolar disorder rs1375055; Suicide attempts in bipolar disorder; bipolar disorder rs1375054; Body mass index; obesity rs3768752; Suicide attempts in bipolar disorder; bipolar disorder rs12619351; Suicide attempts in bipolar disorder; bipolar disorder rs12616328; Multiple complex diseases; Null rs3768751; Suicide attempts in bipolar disorder; bipolar disorder rs3768751; Red blood cell traits; hematopoietic system disease rs3768750; Suicide attempts in bipolar disorder; bipolar disorder rs3768750; Red blood cell traits; hematopoietic system disease rs17034581; Red blood cell traits; hematopoietic system disease rs4952800; Suicide attempts in bipolar disorder; bipolar disorder rs4952800; Red blood cell traits; hematopoietic system disease rs2218660; Suicide attempts in bipolar disorder; bipolar disorder rs2218660; Red blood cell traits; hematopoietic system disease rs17737466; Tourette syndrome; Gilles de la Tourette syndrome\|obsessive-compulsive disorder\|attention deficit hyperactivity disorder rs3768747; Red blood cell traits; hematopoietic system disease rs3754569; Red blood cell traits; hematopoietic system disease rs10495927; Red blood cell traits; hematopoietic system disease rs10495928; Hemoglobin; hemoglobinopathy rs10495928; Blood cell counts and other traits; hematopoietic system disease\|Human immunodeficiency virus infectious disease\|myocardial infarction rs10495928; Red blood cell traits; hematopoietic system disease rs4952801; Red blood cell traits; hematopoietic system disease rs4953318; Other erythrocyte phenotypes; hematopoietic system disease rs4953318; Red blood cell traits; hematopoietic system disease rs13008603; Other erythrocyte phenotypes; hematopoietic system disease rs13008603; Red blood cell traits; hematopoietic system disease rs17737768; Red blood cell traits; hematopoietic system disease rs10184620; Other erythrocyte phenotypes; hematopoietic system disease rs10184620; Red blood cell traits; hematopoietic system disease rs17034610; Body mass index; obesity rs10168349; Hematocrit; hypertension rs10168349; Blood cell counts and other traits; hematopoietic system disease\|Human immunodeficiency virus infectious disease\|myocardial infarction rs10168349; Red blood cell traits; hematopoietic system disease rs12105417; Red blood cell traits; hematopoietic system disease rs10183887; Red blood cell traits; hematopoietic system disease rs10198247; Red blood cell traits; hematopoietic system disease rs13406773; Red blood cell traits; hematopoietic system disease rs13406901; Red blood cell traits; hematopoietic system disease rs11690961; Red blood cell traits; hematopoietic system disease rs6724315; Red blood cell traits; hematopoietic system disease rs13410378; Red blood cell traits; hematopoietic system disease rs12992366; Other erythrocyte phenotypes; hematopoietic system disease rs12992366; Red blood cell traits; hematopoietic system disease rs2053797; Multiple complex diseases; Null rs2053797; Red blood cell traits; hematopoietic system disease rs3754568; Red blood cell traits; hematopoietic system disease rs10495929; Red blood cell traits; hematopoietic system disease rs12990867; Red blood cell traits; hematopoietic system disease rs17034641; Multiple complex diseases; Null rs17034641; Red blood cell traits; hematopoietic system disease rs10495930; Red blood cell traits; hematopoietic system disease rs6544874; Red blood cell traits; hematopoietic system disease rs4953321; Multiple complex diseases; Null rs10205024; Central corneal thickness; open-angle glaucoma\|keratoconus rs10205024; Testosterone levels; breast cancer rs3820729; Red blood cell traits; hematopoietic system disease rs281472; Cognitive test performance; cognitive disorder rs14138; Post-operative nausea and vomiting; Null

Database

Annotation

CTD (Curated)
(count: 11)
(view all)

MESH:D009202 ; Cardiomyopathies
MESH:D015179 ; Colorectal Neoplasms
MESH:D023921 ; Coronary Stenosis
MESH:D003921 ; Diabetes Mellitus, Experimental
MESH:D003928 ; Diabetic Nephropathies
MESH:D006930 ; Hyperalgesia

GWASdb
(count: 135)
(view all)

rs3731949; Myopia (pathological); myopia
rs542413; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension
rs11674329; Hypertension (early onset hypertension); hypertension
rs6743119; Type 2 diabetes; type 2 diabetes mellitus
rs4953246; Obesity (extreme); obesity
rs938661; Urinary metabolites; kidney disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 27) (view all)	181 ATYLRQPTYCSHCRD dbPAF 228 AGLKKQETPDQVGSQ dbPAF 234 ETPDQVGSQRFSVNM dbPAF 261 TFCDHCGSLLWGLLR dbPAF 286 NVHRRCETNVAPNCG dbPAF 309 VLADLGVTPDKITNS dbPAF 314 GVTPDKITNSGQRRK dbPAF 316 TPDKITNSGQRRKKL dbPAF 329 KLIAGAESPQPASGS dbPAF 334 AESPQPASGSSPSEE dbPAF 336 SPQPASGSSPSEEDR dbPAF 337 PQPASGSSPSEEDRS dbPAF 339 PASGSSPSEEDRSKS dbPAF 344 SPSEEDRSKSAPTSP dbPAF 346 SEEDRSKSAPTSPCD dbPAF 349 DRSKSAPTSPCDQEI dbPAF 350 RSKSAPTSPCDQEIK dbPAF 368 NNIRKALSFDNRGEE dbPAF 380 GEEHRAASSPDGQLM dbPAF 381 EEHRAASSPDGQLMS dbPAF 388 SPDGQLMSPGENGEV dbPAF 434 LKGKDEVYAVKVLKK dbPAF 566 LNGVTTTTFCGTPDY dbPAF 573 TFCGTPDYIAPEILQ dbPAF 703 NNFDQDFTREEPVLT dbPAF 710 TREEPVLTLVDEAIV dbPAF 729 QEEFKGFSYFGEDLM dbPAF

PTM

Modification Sites

Phosphorylation
(count: 27)
(view all)

181       ATYLRQPTYCSHCRD     dbPAF
228       AGLKKQETPDQVGSQ     dbPAF
234       ETPDQVGSQRFSVNM     dbPAF
261       TFCDHCGSLLWGLLR     dbPAF
286       NVHRRCETNVAPNCG     dbPAF
309       VLADLGVTPDKITNS     dbPAF

※ Protein-Protein Interaction

Network

Interaction

Source

E9PDT7	Q02156	HPRD
O15399	Q02156	HPRD
O15530	Q02156	HPRD
O75689	Q02156	HPRD
O95819	Q02156	IntAct
P04049	Q02156	HPRD
P04264	Q02156	HPRD
P05556	Q02156	HPRD
P05783	Q02156	HPRD
P06241	Q02156	HPRD
P12235	Q02156	HPRD
P12931	Q02156	HPRD
P13569	Q02156	HPRD
P15056	Q02156	HPRD; MINT
P15924	Q02156	IntAct
P16284	Q02156	HPRD; IntAct
P17252	Q02156	MINT
P17302	Q02156	HPRD
P21796	Q02156	HPRD
P27361	Q02156	HPRD
P28329	Q02156	HPRD
P28482	Q02156	HPRD
P35606	Q02156	HPRD
P37840	Q02156	HPRD
P41143	Q02156	HPRD
P41594	Q02156	HPRD
P42338	Q02156	HPRD
P48751	Q02156	HPRD
P49757	Q02156	HPRD
P51911	Q02156	HPRD
P52789	Q02156	HPRD
P53618	Q02156	HPRD
P63244	Q02156	HPRD
P68032	Q02156	HPRD
P68133	Q02156	HPRD
Q02156	Q02156	HPRD
Q02156	Q05329	HPRD
Q02156	Q05586	HPRD
Q02156	Q06187	HPRD
Q02156	Q07812	IntAct
Q02156	Q13009	HPRD
Q02156	Q14344	HPRD
Q02156	Q15139	HPRD; DIP
Q02156	Q15349	MINT
Q02156	Q8NER1	HPRD
Q02156	Q96A00	HPRD
Q02156	Q96HC4	HPRD
Q02156	Q99259	HPRD
Q02156	Q99996	HPRD
Q02156	Q9UBS0	HPRD
Q02156	Q9UKX2	HPRD

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction