| Tag | Content |
|---|---|
| UniProt Accession | ROR1_HUMAN; Q01973; |
| Entrez ID | 4919 |
| GenBank Protein ID | NM_001083592.1; NM_005012.3; |
| GenBank Nucleotide ID | NP_001077061.1; NP_005003.2; |
| Protein Name | Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1) |
| Gene Name | ROR1; NTRKR1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). |
| Sequence (Fasta) | MHRPRRRGTR PPLLALLAAL LLAARGAAAQ ETELSVSAEL VPTSSWNISS ELNKDSYLTL 60 DEPMNNITTS LGQTAELHCK VSGNPPPTIR WFKNDAPVVQ EPRRLSFRST IYGSRLRIRN 120 LDTTDTGYFQ CVATNGKEVV SSTGVLFVKF GPPPTASPGY SDEYEEDGFC QPYRGIACAR 180 FIGNRTVYME SLHMQGEIEN QITAAFTMIG TSSHLSDKCS QFAIPSLCHY AFPYCDETSS 240 VPKPRDLCRD ECEILENVLC QTEYIFARSN PMILMRLKLP NCEDLPQPES PEAANCIRIG 300 IPMADPINKN HKCYNSTGVD YRGTVSVTKS GRQCQPWNSQ YPHTHTFTAL RFPELNGGHS 360 YCRNPGNQKE APWCFTLDEN FKSDLCDIPA CDSKDSKEKN KMEILYILVP SVAIPLAIAL 420 LFFFICVCRN NQKSSSAPVQ RQPKHVRGQN VEMSMLNAYK PKSKAKELPL SAVRFMEELG 480 ECAFGKIYKG HLYLPGMDHA QLVAIKTLKD YNNPQQWTEF QQEASLMAEL HHPNIVCLLG 540 AVTQEQPVCM LFEYINQGDL HEFLIMRSPH SDVGCSSDED GTVKSSLDHG DFLHIAIQIA 600 AGMEYLSSHF FVHKDLAARN ILIGEQLHVK ISDLGLSREI YSADYYRVQS KSLLPIRWMP 660 PEAIMYGKFS SDSDIWSFGV VLWEIFSFGL QPYYGFSNQE VIEMVRKRQL LPCSEDCPPR 720 MYSLMTECWN EIPSRRPRFK DIHVRLRSWE GLSSHTSSTT PSGGNATTQT TSLSASPVSN 780 LSNPRYPNYM FPSQGITPQG QIAGFIGPPI PQNQRFIPIN GYPIPPGYAA FPAAHYQPTG 840 PPRVIQHCPP PKSRSPSSAS GSTSTGHVTS LPSSGSNQEA NIPLLPHMSI PNHPGGMGIT 900 VFGNKSQKPY KIDSKQASLL GDANIHGHTE SMISAEL 938 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 45) (view all) | rs620019; Alcohol consumption (maxi-drinks); alcohol abuse|alcohol dependence
rs659406; Serum metabolites; Null rs659406; Diabetes Mellitus; diabetes mellitus rs602227; Diabetes Mellitus; diabetes mellitus rs596985; Crohn's disease; Crohn's disease rs631029; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 10) (view all) | 160 PPTASPGYSDEYEED dbPAF
161 PTASPGYSDEYEEDG dbPAF 173 EDGFCQPYRGIACAR dbPAF 576 PHSDVGCSSDEDGTV dbPAF 577 HSDVGCSSDEDGTVK dbPAF 786 SNLSNPRYPNYMFPS dbPAF |
| Ubiquitination (count: 3) | 460 MSMLNAYKPKSKAKE PLMD
489 CAFGKIYKGHLYLPG PLMD 651 DYYRVQSKSLLPIRW PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |