Q01860

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession PO5F1_HUMAN; Q01860;
Entrez ID 5460
GenBank Protein ID NM_001285987.1; NM_002701.5;
GenBank Nucleotide ID NP_001272916.1; NP_002692.2;
Protein Name POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3)
Gene Name POU5F1; OCT3; OCT4; OTF3
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTranscription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Sequence
(Fasta)		MAGHLASDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGPGIGPG VGPGSEVWGI 60
PPCPPPYEFC GGMAYCGPQV GVGLVPQGGL ETSQPEGEAG VGVESNSDGA SPEPCTVTPG 120
AVKLEKEKLE QNPEESQDIK ALQKELEQFA KLLKQKRITL GYTQADVGLT LGVLFGKVFS 180
QTTICRFEAL QLSFKNMCKL RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR 240
VRGNLENLFL QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYAQREDFEA 300
AGSPFSGGPV SFPLAPGPHF GTPGYGSPHF TALYSSVPFP EGEAFPPVSV TTLGSPMHSN 360
361

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1AcetylationBladder cancertumor tissueNK15627369080
[Reference]: Post-translational modifications at Lys-156 and K156N, a somatic mutation detected in bladder cancer patients, both impaired the Lys-151-Asp-107 salt bridge and the Oct4/Sox2 interaction.?
2Lysine MethylationBladder cancertumor tissueNK15627369080
[Reference]: Post-translational modifications at Lys-156 and K156N, a somatic mutation detected in bladder cancer patients, both impaired the Lys-151-Asp-107 salt bridge and the Oct4/Sox2 interaction.?
3UbiquitinationBladder cancertumor tissueNK15627369080
[Reference]: Post-translational modifications at Lys-156 and K156N, a somatic mutation detected in bladder cancer patients, both impaired the Lys-151-Asp-107 salt bridge and the Oct4/Sox2 interaction.?

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
sarcoma
CTD (Curated)
(count: 4)		MESH:D019969 ; Amphetamine-Related Disorders
MESH:D031901 ; Gestational Trophoblastic Disease
MESH:D006330 ; Heart Defects, Congenital
MESH:D009373 ; Neoplasms, Germ Cell and Embryonal
GWASdb
(count: 45)
(view all)		rs3130933; Type 1 diabetes; type 1 diabetes mellitus
rs3130933; Rheumatoid arthritis; rheumatoid arthritis
rs3130933; Multiple sclerosis; multiple sclerosis
rs2394882; HIV-1 control; Human immunodeficiency virus infectious disease
rs2394882; Self-reported allergy; hypersensitivity reaction disease
rs2106074; Multiple complex diseases; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 19)
(view all)		 105       EAGVGVESNSDGASP     dbPAF
107       GVGVESNSDGASPEP     dbPAF
111       ESNSDGASPEPCTVT     dbPAF
116       GASPEPCTVTPGAVK     dbPAF
118       SPEPCTVTPGAVKLE     dbPAF
12        LASDFAFSPPPGGGG     dbPAF
Sumoylation
(count: 1)		 123       TVTPGAVKLEKEKLE     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource