Q01279

※ Protein Information

Tag	Content
UniProt Accession	EGFR_MOUSE; Q01279;
Entrez ID	13649
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Epidermal growth factor receptor (EC 2.7.10.1)
Gene Name	Egfr
Organism	Mus musculus
NCBI Taxa ID	10090
Functional Description	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Ac(view all) Functional Description Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (PubMed:20639532).
Sequence (Fasta)	MRPSGTARTT LLVLLTALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS LQRMYNNCEV 60 VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN ALYENTYALA 120 ILSNYGTNRT GLRELPMRNL QEILIGAVRF SNNPILCNMD TIQWRDIVQN VFMSNMSMDL 180 QSHPSSCPKC DPSCPNGSCW GGGEENCQKL TKIICAQQCS HRCRGRSPSD CCHNQCAAGC 240 TGPRESDCLV CQKFQDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300 VTDHGSCVRA CGPDYYEVEE DGIRKCKKCD GPCRKVCNGI GIGEFKDTLS INATNIKHFK 360 YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE ITGFLLIQAW PDNWTDLHAF 420 ENLEIIRGRT KQHGQFSLAV VGLNITSLGL RSLKEISDGD VIISGNRNLC YANTINWKKL 480 FGTPNQKTKI MNNRAEKDCK AVNHVCNPLC SSEGCWGPEP RDCVSCQNVS RGRECVEKCN 540 ILEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGIM 600 GENNTLVWKY ADANNVCHLC HANCTYGCAG PGLQGCEVWP SGPKIPSIAT GIVGGLLFIV 660 VVALGIGLFM RRRHIVRKRT LRRLLQEREL VEPLTPSGEA PNQAHLRILK ETEFKKIKVL 720 GSGAFGTVYK GLWIPEGEKV KIPVAIKELR EATSPKANKE ILDEAYVMAS VDNPHVCRLL 780 GICLTSTVQL ITQLMPYGCL LDYVREHKDN IGSQYLLNWC VQIAKGMNYL EDRRLVHRDL 840 AARNVLVKTP QHVKITDFGL AKLLGAEEKE YHAEGGKVPI KWMALESILH RIYTHQSDVW 900 SYGVTVWELM TFGSKPYDGI PASDISSILE KGERLPQPPI CTIDVYMIMV KCWMIDADSR 960 PKFRELILEF SKMARDPQRY LVIQGDERMH LPSPTDSNFY RALMDEEDME DVVDADEYLI 1020 PQQGFFNSPS TSRTPLLSSL SATSNNSTVA CINRNGSCRV KEDAFLQRYS SDPTGAVTED 1080 NIDDAFLPVP EYVNQSVPKR PAGSVQNPVY HNQPLHPAPG RDLHYQNPHS NAVGNPEYLN 1140 TAQPTCLSSG FNSPALWIQK GSHQMSLDNP DYQQDFFPKE TKPNGIFKGP TAENAEYLRV 1200 APPSSEFIGA 1211 Fasta Sequence >Q01279\|Egfr\|Mus musculus (Mouse) MRPSGTARTTLLVLLTALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMYNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDLQSHPSSCPKCDPSCPNGSCWGGGEENCQKLTKIICAQQCSHRCRGRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSATSNNSTVACINRNGSCRVKEDAFLQRYSSDPTGAVTEDNIDDAFLPVPEYVNQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVGNPEYLNTAQPTCLSSGFNSPALWIQKGSHQMSLDNPDYQQDFFPKETKPNGIFKGPTAENAEYLRVAPPSSEFIGA

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Phosphorylation	Joint disease		U		24670222
1	[Reference]: Phospho-EGFR staining in surgery knees decreased for WT mice and increased for Mig-6-/- mice. Fewer inflammatory cells were present in WT knees.
2	Tyrosine Phosphorylation	Head and neck squamous cell carcinoma	CAL 27 cell line	P	Y1068	23265944
2	[Reference]: Downregulation of CD44 in CAL27 cells inhibited constitutive EGFR phosphorylation and significantly reduced tumor growth in nude mice

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 48) (view all)	MESH:D058186 ; Acute Kidney Injury MESH:D000230 ; Adenocarcinoma MESH:C538231 ; Adenocarcinoma of lung MESH:D011125 ; Adenomatous Polyposis Coli MESH:D018268 ; Adrenocortical Carcinoma MESH:D001169 ; Arthritis, Experimental MESH:D001650 ; Bile Duct Neoplasms MESH:D001943 ; Breast Neoplasms MESH:D002277 ; Carcinoma MESH:D006528 ; Carcinoma, Hepatocellular MESH:D002294 ; Carcinoma, Squamous Cell MESH:D002311 ; Cardiomyopathy, Dilated MESH:D054506 ; Chloracne MESH:D018281 ; Cholangiocarcinoma MESH:D003110 ; Colonic Neoplasms MESH:D015179 ; Colorectal Neoplasms MESH:D019465 ; Craniofacial Abnormalities MESH:D003924 ; Diabetes Mellitus, Type 2 MESH:D018450 ; Disease Progression MESH:D004715 ; Endometriosis MESH:D004938 ; Esophageal Neoplasms MESH:C562729 ; Esophageal Squamous Cell Carcinoma MESH:D005706 ; Gallbladder Neoplasms MESH:D005909 ; Glioblastoma MESH:D006258 ; Head and Neck Neoplasms OMIM:616069 ; INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 2 MESH:D007333 ; Insulin Resistance MESH:D008175 ; Lung Neoplasms MESH:D015674 ; Mammary Neoplasms, Animal MESH:D008325 ; Mammary Neoplasms, Experimental MESH:D008654 ; Mesothelioma MESH:C562839 ; Mesothelioma, Malignant MESH:D009303 ; Nasopharyngeal Neoplasms MESH:D009361 ; Neoplasm Invasiveness MESH:D009362 ; Neoplasm Metastasis MESH:D009364 ; Neoplasm Recurrence, Local MESH:D002289 ; Carcinoma, Non-Small-Cell Lung MESH:D012516 ; Osteosarcoma MESH:D010051 ; Ovarian Neoplasms MESH:D010190 ; Pancreatic Neoplasms MESH:D010212 ; Papilloma MESH:D017044 ; Polycystic Kidney, Autosomal Recessive MESH:D011471 ; Prostatic Neoplasms MESH:D012004 ; Rectal Neoplasms MESH:D055752 ; Small Cell Lung Carcinoma MESH:D013274 ; Stomach Neoplasms MESH:D001749 ; Urinary Bladder Neoplasms MESH:D002583 ; Uterine Cervical Neoplasms

Database

Annotation

CTD (Curated)
(count: 48)
(view all)

MESH:D058186 ; Acute Kidney Injury
MESH:D000230 ; Adenocarcinoma
MESH:C538231 ; Adenocarcinoma of lung
MESH:D011125 ; Adenomatous Polyposis Coli
MESH:D018268 ; Adrenocortical Carcinoma
MESH:D001169 ; Arthritis, Experimental

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 30) (view all)	1000 SPTDSNFYRALMDEE dbPAF 1018 DVVDADEYLIPQQGF dbPAF 1028 PQQGFFNSPSTSRTP dbPAF 1034 NSPSTSRTPLLSSLS dbPAF 1041 TPLLSSLSATSNNST dbPAF 1043 LLSSLSATSNNSTVA dbPAF 1044 LSSLSATSNNSTVAC dbPAF 1047 LSATSNNSTVACINR dbPAF 1057 ACINRNGSCRVKEDA dbPAF 1069 EDAFLQRYSSDPTGA dbPAF 1070 DAFLQRYSSDPTGAV dbPAF 1071 AFLQRYSSDPTGAVT dbPAF 1074 QRYSSDPTGAVTEDN dbPAF 1092 AFLPVPEYVNQSVPK dbPAF 1104 VPKRPAGSVQNPVYH dbPAF 1110 GSVQNPVYHNQPLHP dbPAF 1138 NAVGNPEYLNTAQPT dbPAF 1153 CLSSGFNSPALWIQK dbPAF 1162 ALWIQKGSHQMSLDN dbPAF 1166 QKGSHQMSLDNPDYQ dbPAF 1172 MSLDNPDYQQDFFPK dbPAF 1197 PTAENAEYLRVAPPS dbPAF 270 TCPPLMLYNPTTYQM dbPAF 316 RACGPDYYEVEEDGI dbPAF 695 RELVEPLTPSGEAPN dbPAF 729 SGAFGTVYKGLWIPE dbPAF 871 LGAEEKEYHAEGGKV dbPAF 993 DERMHLPSPTDSNFY dbPAF 995 RMHLPSPTDSNFYRA dbPAF 997 HLPSPTDSNFYRALM dbPAF
Ubiquitination (count: 19) (view all)	1061 RNGSCRVKEDAFLQR PLMD 1179 YQQDFFPKETKPNGI PLMD 1182 DFFPKETKPNGIFKG PLMD 1188 TKPNGIFKGPTAENA PLMD 454 SLGLRSLKEISDGDV PLMD 487 LFGTPNQKTKIMNNR PLMD 710 QAHLRILKETEFKKI PLMD 730 GAFGTVYKGLWIPEG PLMD 739 LWIPEGEKVKIPVAI PLMD 741 IPEGEKVKIPVAIKE PLMD 747 VKIPVAIKELREATS PLMD 759 ATSPKANKEILDEAY PLMD 848 AARNVLVKTPQHVKI PLMD 854 VKTPQHVKITDFGLA PLMD 862 ITDFGLAKLLGAEEK PLMD 869 KLLGAEEKEYHAEGG PLMD 877 EYHAEGGKVPIKWMA PLMD 931 DISSILEKGERLPQP PLMD 972 ELILEFSKMARDPQR PLMD

PTM

Modification Sites

Phosphorylation
(count: 30)
(view all)

1000      SPTDSNFYRALMDEE     dbPAF
1018      DVVDADEYLIPQQGF     dbPAF
1028      PQQGFFNSPSTSRTP     dbPAF
1034      NSPSTSRTPLLSSLS     dbPAF
1041      TPLLSSLSATSNNST     dbPAF
1043      LLSSLSATSNNSTVA     dbPAF

Ubiquitination
(count: 19)
(view all)

1061      RNGSCRVKEDAFLQR     PLMD
1179      YQQDFFPKETKPNGI     PLMD
1182      DFFPKETKPNGIFKG     PLMD
1188      TKPNGIFKGPTAENA     PLMD
454       SLGLRSLKEISDGDV     PLMD
487       LFGTPNQKTKIMNNR     PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

P01132

Q01279

DIP

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction