Q01147

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession CREB1_MOUSE; Q01147;
Entrez ID 12912
GenBank Protein ID NM_009952.2; NM_133828.2; XM_006495650.3; XM_006495651.3; XM_017314080.1; XM_017314099.1;
GenBank Nucleotide ID NP_034082.1; NP_598589.2; XP_006495713.1; XP_006495714.1; XP_017169569.1; XP_017169588.1;
Protein Name Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1)
Gene Name Creb1; Creb-1
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionPhosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Sequence
(Fasta)		MTMESGADNQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN 60
GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT QISTIAESED SQESVDSVTD 120
SQKRREILSR RPSYRKILND LSSDAPGVPR IEEEKSEEET SAPAITTVTV PTPIYQTSSG 180
QYIAITQGGA IQLANNGTDG VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV 240
VVQAASGDVQ TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC 300
RRKKKEYVKC LENRVAVLEN QNKTLIEELK ALKDLYCHKS D 342

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationHeart failureNS13317616745
[Reference]: Left ventricular contractile function was substantially reduced in CREB-S133A mice versus NTG mice and only modestly reduced in CREB-S133A-LZ mice (P < 0.02).?

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 5)		MESH:D019970 ; Cocaine-Related Disorders
MESH:C563181 ; Histiocytoma, Angiomatoid Fibrous
MESH:D009021 ; Morphine Dependence
MESH:D009203 ; Myocardial Infarction
MESH:D013375 ; Substance Withdrawal Syndrome

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 17)
(view all)		 100       LKRLFSGTQISTIAE     dbPAF
108       QISTIAESEDSQESV     dbPAF
111       TIAESEDSQESVDSV     dbPAF
114       ESEDSQESVDSVTDS     dbPAF
117       DSQESVDSVTDSQKR     dbPAF
121       SVDSVTDSQKRREIL     dbPAF
Ubiquitination
(count: 2)		 136       SRRPSYRKILNDLSS     PLMD
330       KTLIEELKALKDLYC     PLMD