Q01130

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession SRSF2_HUMAN; Q01130;
Entrez ID 6427
GenBank Protein ID NM_001195427.1; NM_003016.4; XM_017024942.1;
GenBank Nucleotide ID NP_001182356.1; NP_003007.2; XP_016880431.1;
Protein Name Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Gene Name SRSF2; SFRS2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionNecessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.
Sequence
(Fasta)
MSYGRPPPDV EGMTSLKVDN LTYRTSPDTL RRVFEKYGRV GDVYIPRDRY TKESRGFAFV 60
RFHDKRDAED AMDAMDGAVL DGRELRVQMA RYGRPPDSHH SRRGPPPRRY GGGGYGRRSR 120
SPRRRRRSRS RSRSRSRSRS RSRYSRSKSR SRTRSRSRST SKSRSARRSK SKSSSVSRSR 180
SRSRSRSRSR SPPPVSKRES KSRSRSKSPP KSPEEEGAVS S 222

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationNeuroendocrine lung cancertumor tissueU23518498
[Reference]: SRSF2 and P-SRSF2 proteins are overexpressed in neuroendocrine lung tumors

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
MDS, CLL
CTD (Curated)
(count: 4)
MESH:D002277 ; Carcinoma
MESH:D015674 ; Mammary Neoplasms, Animal
MESH:D008325 ; Mammary Neoplasms, Experimental
MESH:D013494 ; Supranuclear Palsy, Progressive
GWASdb
(count: 1)
rs3744061; Retinal arteriolar caliber; retinal vascular disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 33)
(view all)
101       RPPDSHHSRRGPPPR     dbPAF
110       RGPPPRRYGGGGYGR     dbPAF
115       RRYGGGGYGRRSRSP     dbPAF
121       GYGRRSRSPRRRRRS     dbPAF
128       SPRRRRRSRSRSRSR     dbPAF
130       RRRRRSRSRSRSRSR     dbPAF
Acetylation
(count: 2)
36        TLRRVFEKYGRVGDV     PLMD
52        IPRDRYTKESRGFAF     PLMD
Ubiquitination
(count: 1)
36        TLRRVFEKYGRVGDV     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource