Tag | Content |
---|---|
UniProt Accession | INSM1_HUMAN; Q01101; |
Entrez ID | 3642 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Insulinoma-associated protein 1 (Zinc finger protein IA-1) |
Gene Name | INSM1; IA1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Repr(view all) |
Sequence (Fasta) | MPRGFLVKRS KKSTPVSYRV RGGEDGDRAL LLSPSCGGAR AEPPAPSPVP GPLPPPPPAE 60 RAHAALAAAL ACAPGPQPPP QGPRAAHFGN PEAAHPAPLY SPTRPVSREH EKHKYFERSF 120 NLGSPVSAES FPTPAALLGG GGGGGASGAG GGGTCGGDPL LFAPAELKMG TAFSAGAEAA 180 RGPGPGPPLP PAAALRPPGK RPPPPTAAEP PAKAVKAPGA KKPKAIRKLH FEDEVTTSPV 240 LGLKIKEGPV EAPRGRAGGA ARPLGEFICQ LCKEEYADPF ALAQHKCSRI VRVEYRCPEC 300 AKVFSCPANL ASHRRWHKPR PAPAAARAPE PEAAARAEAR EAPGGGSDRD TPSPGGVSES 360 GSEDGLYECH HCAKKFRRQA YLRKHLLAHH QALQAKGAPL APPAEDLLAL YPGPDEKAPQ 420 EAAGDGEGAG VLGLSASAEC HLCPVCGESF ASKGAQERHL RLLHAAQVFP CKYCPATFYS 480 SPGLTRHINK CHPSENRQVI LLQVPVRPAC 511 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 1) | MESH:D055752 ; Small Cell Lung Carcinoma |
DisGeNet (Curated) (count: 1) | C0149925; Small cell carcinoma of lung |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 1) | 358 TPSPGGVSESGSEDG dbPAF |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |