| Tag | Content |
|---|---|
| UniProt Accession | E2F1_HUMAN; Q01094; |
| Entrez ID | 1869 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) |
| Gene Name | E2F1; RBBP3 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599). |
| Sequence (Fasta) | MALAGAPAGG PCAPALEALL GAGALRLLDS SQIVIISAAQ DASAPPAPTG PAAPAAGPCD 60 PDLLLFATPQ APRPTPSAPR PALGRPPVKR RLDLETDHQY LAESSGPARG RGRHPGKGVK 120 SPGEKSRYET SLNLTTKRFL ELLSHSADGV VDLNWAAEVL KVQKRRIYDI TNVLEGIQLI 180 AKKSKNHIQW LGSHTTVGVG GRLEGLTQDL RQLQESEQQL DHLMNICTTQ LRLLSEDTDS 240 QRLAYVTCQD LRSIADPAEQ MVMVIKAPPE TQLQAVDSSE NFQISLKSKQ GPIDVFLCPE 300 ETVGGISPGK TPSQEVTSEE ENRATDSATI VSPPPSSPPS SLTTDPSQSL LSLEQEPLLS 360 RMGSLRAPVD EDRLSPLVAA DSLLEHVRED FSGLLPEEFI SLSPPHEALD YHFGLEEGEG 420 IRDLFDCDFG DLTPLDF 438 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 3) | MESH:D001943
; Breast Neoplasms MESH:D006528 ; Carcinoma, Hepatocellular MESH:D008545 ; Melanoma |
| DisGeNet (Curated) (count: 3) | C0025202; melanoma
C1458155; Mammary Neoplasms C2239176; Liver carcinoma |
| GWASdb (count: 2) | rs2071054; Melanoma; skin melanoma
rs3213150; Pericardial fat; myocardial infarction |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 13) (view all) | 135 YETSLNLTTKRFLEL dbPAF
136 ETSLNLTTKRFLELL dbPAF 307 EETVGGISPGKTPSQ dbPAF 31 ALRLLDSSQIVIISA dbPAF 332 TDSATIVSPPPSSPP dbPAF 337 IVSPPPSSPPSSLTT dbPAF |
| Acetylation (count: 3) | 117 GRGRHPGKGVKSPGE PLMD
120 RHPGKGVKSPGEKSR PLMD 125 GVKSPGEKSRYETSL PLMD |
| Methylation (count: 1) | 185 QLIAKKSKNHIQWLG PLMD |
| Neddylation (count: 4) | 117 GRGRHPGKGVKSPGE PLMD
120 RHPGKGVKSPGEKSR PLMD 125 GVKSPGEKSRYETSL PLMD 185 QLIAKKSKNHIQWLG PLMD |