Tag | Content |
---|---|
UniProt Accession | HSF1_HUMAN; Q00613; |
Entrez ID | 3297 |
GenBank Protein ID | NM_005526.3; XM_017013377.1; |
GenBank Nucleotide ID | NP_005517.1; XP_016868866.1; |
Protein Name | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) |
Gene Name | HSF1; HSTF1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Function as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage (PubMed:1871105, PubMed:11447121, PubMed:1986252, PubMed:7760831, PubMed:7623826, PubMed:8946918, PubMed:8940068, PubMed:9341107, PubMed:9121459, PubMed:9727490, PubMed:9499401, PubMed:9535852, PubMed:12659875, PubMed:12917326, PubMed:15016915, (view all) |
Sequence (Fasta) | MDLPVGPGAA GPSNVPAFLT KLWTLVSDPD TDALICWSPS GNSFHVFDQG QFAKEVLPKY 60 FKHNNMASFV RQLNMYGFRK VVHIEQGGLV KPERDDTEFQ HPCFLRGQEQ LLENIKRKVT 120 SVSTLKSEDI KIRQDSVTKL LTDVQLMKGK QECMDSKLLA MKHENEALWR EVASLRQKHA 180 QQQKVVNKLI QFLISLVQSN RILGVKRKIP LMLNDSGSAH SMPKYSRQFS LEHVHGSGPY 240 SAPSPAYSSS SLYAPDAVAS SGPIISDITE LAPASPMASP GGSIDERPLS SSPLVRVKEE 300 PPSPPQSPRV EEASPGRPSS VDTLLSPTAL IDSILRESEP APASVTALTD ARGHTDTEGR 360 PPSPPPTSTP EKCLSVACLD KNELSDHLDA MDSNLDNLQT MLSSHGFSVD TSALLDLFSP 420 SVTVPDMSLP DLDSSLASIQ ELLSPQEPPR PPEAENSSPD SGKQLVHYTA QPLFLLDPGS 480 VDTGSNDLPV LFELGEGSYF SEGDGFAEDP TISLLTGSEP PKAKDPTVS |
|
Database | Annotation |
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CTD (Curated) (count: 2) | MESH:C531617
; Amyotrophic lateral sclerosis 1 MESH:D009369 ; Neoplasms |
DisGeNet (Curated) (count: 3) | C0011570; Mental Depression
C0011581; Depressive disorder C1862939; AMYOTROPHIC LATERAL SCLEROSIS 1 |
GWASdb (count: 1) | rs4977219; Type 2 diabetes; type 2 diabetes mellitus |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 36) (view all) | 120 ENIKRKVTSVSTLKS dbPAF
121 NIKRKVTSVSTLKSE dbPAF 127 TSVSTLKSEDIKIRQ dbPAF 142 DSVTKLLTDVQLMKG dbPAF 216 IPLMLNDSGSAHSMP dbPAF 218 LMLNDSGSAHSMPKY dbPAF |
Acetylation (count: 9) (view all) | 116 EQLLENIKRKVTSVS PLMD
118 LLENIKRKVTSVSTL PLMD 126 VTSVSTLKSEDIKIR PLMD 148 LTDVQLMKGKQECMD PLMD 157 KQECMDSKLLAMKHE PLMD 208 RILGVKRKIPLMLND PLMD |
Ubiquitination (count: 5) | 116 EQLLENIKRKVTSVS PLMD
148 LTDVQLMKGKQECMD PLMD 208 RILGVKRKIPLMLND PLMD 54 FDQGQFAKEVLPKYF PLMD 62 EVLPKYFKHNNMASF PLMD |
Sumoylation (count: 6) | 126 VTSVSTLKSEDIKIR PLMD
157 KQECMDSKLLAMKHE PLMD 208 RILGVKRKIPLMLND PLMD 224 GSAHSMPKYSRQFSL PLMD 298 SSPLVRVKEEPPSPP PLMD 91 IEQGGLVKPERDDTE PLMD |
Malonylation (count: 1) | 62 EVLPKYFKHNNMASF PLMD |
Network | Interaction | ||
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A | B | Source | |