Q00613

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession HSF1_HUMAN; Q00613;
Entrez ID 3297
GenBank Protein ID NM_005526.3; XM_017013377.1;
GenBank Nucleotide ID NP_005517.1; XP_016868866.1;
Protein Name Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1)
Gene Name HSF1; HSTF1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionFunction as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage (PubMed:1871105, PubMed:11447121, PubMed:1986252, PubMed:7760831, PubMed:7623826, PubMed:8946918, PubMed:8940068, PubMed:9341107, PubMed:9121459, PubMed:9727490, PubMed:9499401, PubMed:9535852, PubMed:12659875, PubMed:12917326, PubMed:15016915, (view all)
Sequence
(Fasta)
MDLPVGPGAA GPSNVPAFLT KLWTLVSDPD TDALICWSPS GNSFHVFDQG QFAKEVLPKY 60
FKHNNMASFV RQLNMYGFRK VVHIEQGGLV KPERDDTEFQ HPCFLRGQEQ LLENIKRKVT 120
SVSTLKSEDI KIRQDSVTKL LTDVQLMKGK QECMDSKLLA MKHENEALWR EVASLRQKHA 180
QQQKVVNKLI QFLISLVQSN RILGVKRKIP LMLNDSGSAH SMPKYSRQFS LEHVHGSGPY 240
SAPSPAYSSS SLYAPDAVAS SGPIISDITE LAPASPMASP GGSIDERPLS SSPLVRVKEE 300
PPSPPQSPRV EEASPGRPSS VDTLLSPTAL IDSILRESEP APASVTALTD ARGHTDTEGR 360
PPSPPPTSTP EKCLSVACLD KNELSDHLDA MDSNLDNLQT MLSSHGFSVD TSALLDLFSP 420
SVTVPDMSLP DLDSSLASIQ ELLSPQEPPR PPEAENSSPD SGKQLVHYTA QPLFLLDPGS 480
VDTGSNDLPV LFELGEGSYF SEGDGFAEDP TISLLTGSEP PKAKDPTVS

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationOvarian cancer/carcinomaUS32628415561
[Reference]: Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)
MESH:C531617 ; Amyotrophic lateral sclerosis 1
MESH:D009369 ; Neoplasms
DisGeNet (Curated)
(count: 3)
C0011570; Mental Depression
C0011581; Depressive disorder
C1862939; AMYOTROPHIC LATERAL SCLEROSIS 1
GWASdb
(count: 1)
rs4977219; Type 2 diabetes; type 2 diabetes mellitus

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 36)
(view all)
120       ENIKRKVTSVSTLKS     dbPAF
121       NIKRKVTSVSTLKSE     dbPAF
127       TSVSTLKSEDIKIRQ     dbPAF
142       DSVTKLLTDVQLMKG     dbPAF
216       IPLMLNDSGSAHSMP     dbPAF
218       LMLNDSGSAHSMPKY     dbPAF
Acetylation
(count: 9)
(view all)
116       EQLLENIKRKVTSVS     PLMD
118       LLENIKRKVTSVSTL     PLMD
126       VTSVSTLKSEDIKIR     PLMD
148       LTDVQLMKGKQECMD     PLMD
157       KQECMDSKLLAMKHE     PLMD
208       RILGVKRKIPLMLND     PLMD
Ubiquitination
(count: 5)
116       EQLLENIKRKVTSVS     PLMD
148       LTDVQLMKGKQECMD     PLMD
208       RILGVKRKIPLMLND     PLMD
54        FDQGQFAKEVLPKYF     PLMD
62        EVLPKYFKHNNMASF     PLMD
Sumoylation
(count: 6)
126       VTSVSTLKSEDIKIR     PLMD
157       KQECMDSKLLAMKHE     PLMD
208       RILGVKRKIPLMLND     PLMD
224       GSAHSMPKYSRQFSL     PLMD
298       SSPLVRVKEEPPSPP     PLMD
91        IEQGGLVKPERDDTE     PLMD
Malonylation
(count: 1)
62        EVLPKYFKHNNMASF     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource