Tag | Content |
---|---|
UniProt Accession | CDK5_HUMAN; Q00535; |
Entrez ID | 1020 |
GenBank Protein ID | NM_001164410.2; NM_004935.3; |
GenBank Nucleotide ID | NP_001157882.1; NP_004926.1; |
Protein Name | Cyclin-dependent-like kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) |
Gene Name | CDK5; CDKN5 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates s(view all) |
Sequence (Fasta) | MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH 60 KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR 120 NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS 180 TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP 240 MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP 293 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 2) | OMIM:616342
; LISSENCEPHALY 7 WITH CEREBELLAR HYPOPLASIA MESH:D024801 ; Tauopathies |
DisGeNet (Curated) (count: 30) (view all) | C0003886; Arthrogryposis
C0019572; Hirsutism C0024236; Lymphedema C0025990; Micrognathism C0036341; Schizophrenia C0175754; Agenesis of corpus callosum |
GWASdb (count: 1) | rs891507; Insulin resistance; type 2 diabetes mellitus |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 13) (view all) | 105 LDPEIVKSFLFQLLK dbPAF
14 LEKIGEGTYGTVFKA dbPAF 15 EKIGEGTYGTVFKAK dbPAF 158 FGIPVRCYSAEVVTL dbPAF 159 GIPVRCYSAEVVTLW dbPAF 167 AEVVTLWYRPPDVLF dbPAF |
Acetylation (count: 6) | 20 GTYGTVFKAKNRETH PLMD
33 THEIVALKRVRLDDD PLMD 56 LREICLLKELKHKNI PLMD 6 **MQKYEKLEKIGEG PLMD 74 HDVLHSDKKLTLVFE PLMD 9 QKYEKLEKIGEGTYG PLMD |
Ubiquitination (count: 16) (view all) | 128 NVLHRDLKPQNLLIN PLMD
141 INRNGELKLADFGLA PLMD 20 GTYGTVFKAKNRETH PLMD 213 NDVDDQLKRIFRLLG PLMD 232 EQWPSMTKLPDYKPY PLMD 237 MTKLPDYKPYPMYPA PLMD |
Sumoylation (count: 4) | 128 NVLHRDLKPQNLLIN PLMD
237 MTKLPDYKPYPMYPA PLMD 3 *****MQKYEKLEKI PLMD 9 QKYEKLEKIGEGTYG PLMD |
Glycation (count: 1) | 104 DLDPEIVKSFLFQLL PLMD |
Malonylation (count: 2) | 56 LREICLLKELKHKNI PLMD
9 QKYEKLEKIGEGTYG PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |