Tag | Content |
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UniProt Accession | CSF1R_RAT; Q00495; |
Entrez ID | 307403 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115) |
Gene Name | Csf1r; Csfmr; Fms |
Organism | Rattus norvegicus |
NCBI Taxa ID | 10116 |
Functional Description | Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of (view all) |
Sequence (Fasta) | MELGPPLVLL LATVWHGQGA PVIEPSGPEL VVEPGETVTL RCVSNGSVEW DGPISPYWTL 60 DPESPGSTLT TRNATFKNTG TYRCTELEDP MAGSTTIHLY VKDPAHSWNL LAQEVTVVEG 120 QEAVLPCLIT DPALKDSVSL MREGGRQVLR KTVYFFSAWR GFIIRKAKVL DSNTYVCKTM 180 VNGRESTSTG IWLKVNRVHP EPPQIKLEPS KLVRIRGEAA QIVCSATNAE VGFNVILKRG 240 DTKLEIPLNS DFQDNYYKKV RALSLNAVDF QDAGIYSCVA SNDVGTRTAT MNFQVVESAY 300 LNLTSEQSLL QEVSVGDSLI LTVHADAYPS IQHYNWTYLG PFFEDQRKLE FITQRAIYRY 360 TFKLFLNRVK ASEAGQYFLM AQNKAGWNNL TFELTLRYPP EVSVTWMPVN GSDVLFCDVS 420 GYPQPSVTWM ECRGHTDRCD EAQALQVWND THPEVLSQKP FDKVIIQSQL PIGTLKHNMT 480 YFCKTHNSVG NSSQYFRAVS LGQSKQLPDE SLFTPVVVAC MSVMSLLVLL LLLLLYKYKQ 540 KPKYQVRWKI IERYEGNSYT FIDPTQLPYN EKWEFPRNNL QFGKTLGAGA FGKVVEATAF 600 GLGKEDAVLK VAVKMLKSTA HADEKEALMS ELKIMSHLGQ HENIVNLLGA CTHGGPVLVI 660 TEYCCYGDLL NFLRRKAEAM LGPSLSPGQD SEGDSSYKNI HLEKKYVRRD SGFSSQGVDT 720 YVEMRPVSTS SSDSFFKQDL DKEPSRPLEL WDLLHFSSQV AQGMAFLASK NCIHRDVAAR 780 NVLLTSGHVA KIGDFGLARD IMNDSNYVVK GNARLPVKWM APESILYCVY TVQSDVWSYG 840 ILLWEIFSLG LNPYPGILVN NKFYKLVKDG YQMAQPVFAP KNIYSIMQSC WDLEPTRRPT 900 FQQICFLLQE QARLERRDQD YANLPSSGGS SGSDSGGGSS GGSSSEPEEE SSSEHLACCE 960 PGDIAQPLLQ PNNYQFAC 979 |
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Database | Annotation |
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CTD (Curated) (count: 7) (view all) | MESH:D001943
; Breast Neoplasms MESH:C580150 ; Hereditary Diffuse Leukoencephalopathy with Spheroids MESH:D015470 ; Leukemia, Myeloid, Acute MESH:D056784 ; Leukoencephalopathies MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D009362 ; Neoplasm Metastasis |
PTM | Modification Sites |
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Phosphorylation (count: 2) | 711 KKYVRRDSGFSSQGV dbPAF
714 VRRDSGFSSQGVDTY dbPAF |
Ubiquitination (count: 1) | 604 ATAFGLGKEDAVLKV PLMD |