Tag | Content |
---|---|
UniProt Accession | SHC1_MOUSE; P98083; |
Entrez ID | 20416 |
GenBank Protein ID | NM_001113331.2; NM_011368.5; |
GenBank Nucleotide ID | NP_001106802.1; NP_035498.2; |
Protein Name | SHC-transforming protein 1 (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) |
Gene Name | Shc1; Shc; ShcA |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitog(view all) |
Sequence (Fasta) | MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP GDDSPTTLCS 60 FFPRMSNLKL ANPAGGRLGP KGEPGKAAED GEGSAGAALR DSGLLPLLQD MNKLSGGGGR 120 RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD 180 FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS 240 LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV 300 ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL 360 GGVVDMRLRE GAARPTLPSA QMSSHLGATL PIGQHAAGDH EVRKQMLPPP PCPGRELFDD 420 PSYVNIQNLD KARQAGGGAG PPNPSLNGSA PRDLFDMKPF EDALRVPPPP QSMSMAEQLQ 480 GEPWFHGKLS RREAEALLQL NGDFLVREST TTPGQYVLTG LQSGQPKHLL LVDPEGVVRT 540 KDHRFESVSH LISYHMDNHL PIISAGSELC LQQPVDRKV |
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Database | Annotation |
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CTD (Curated) (count: 2) | MESH:C531617
; Amyotrophic lateral sclerosis 1 MESH:D006332 ; Cardiomegaly |
PTM | Modification Sites |
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Phosphorylation (count: 13) (view all) | 115 LQDMNKLSGGGGRRT dbPAF
139 EEWTRHGSFVNKPTR dbPAF 145 GSFVNKPTRGWLHPN dbPAF 264 MQSISFASGGDPDTA dbPAF 315 FELRFKQYLRNPPKL dbPAF 349 EEPPDHQYYNDFPGK dbPAF |
Acetylation (count: 1) | 154 GWLHPNDKVMGPGVS PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |