| Tag | Content |
|---|---|
| UniProt Accession | DOK1_MOUSE; P97465; |
| Entrez ID | 13448 |
| GenBank Protein ID | NM_001291799.1; NM_010070.4; |
| GenBank Nucleotide ID | NP_001278728.1; NP_034200.4; |
| Protein Name | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) |
| Gene Name | Dok1; Dok |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). |
| Sequence (Fasta) | MDGAVMEGPL FLQSQRFGTK RWRKTWAVLY PASPHGVARL EFFDHKGSSS RGGRGGSRRL 60 DCKMIRLAEC VSVVPVTVES PPEPGAVAFR LDTAQRSHLL AADAVSSTAW VQTLCRTAFP 120 KGGWALAQTE NQPKFSALEM LENSLYSPTW EGSQFWVTSQ KTEASERCGL QGSYILRVEA 180 EKLTLLTLGA QSQILEPLLF WPYTLLRRYG RDKVMFSFEA GRRCPSGPGT FTFQTSQGND 240 IFQAVEAAIQ QQKAQGKVGQ AQDILRTDSH DGETEGKTVP PPVPQDPLGS PPALYAEPLD 300 SLRIPPGPSQ DSVYSDPLGS TPAGAGEGVH SKKPLYWDLY GHVQQQLLKT KLTDSKEDPI 360 YDEPEGLAPA PPRGLYDLPQ EPRDAWWCQA RLKEEGYELP YNPATDDYAV PPPRSPKPAP 420 APKPQGLILP ESGTTRGSGS KGFSSDTALY SQVQKSGTSG AWDCGLSKVG NDRAGVKSEG 480 ST 483 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 2) | MESH:D008175
; Lung Neoplasms MESH:D010051 ; Ovarian Neoplasms |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 30) (view all) | 136 TENQPKFSALEMLEN dbPAF
146 EMLENSLYSPTWEGS dbPAF 267 QAQDILRTDSHDGET dbPAF 269 QDILRTDSHDGETEG dbPAF 274 TDSHDGETEGKTVPP dbPAF 290 VPQDPLGSPPALYAE dbPAF |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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