P78362

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession SRPK2_HUMAN; P78362;
Entrez ID 6733
GenBank Protein ID NM_001278273.1; NM_182691.2; NM_182692.2; XM_017012566.1;
GenBank Nucleotide ID NP_001265202.1; NP_872633.1; NP_872634.1; XP_016868055.1;
Protein Name SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene Name SRPK2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionSerine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phospho(view all)
Sequence
(Fasta)		MSVNSEKSSS SERPEPQQKA PLVPPPPPPP PPPPPPLPDP TPPEPEEEIL GSDDEEQEDP 60
ADYCKGGYHP VKIGDLFNGR YHVIRKLGWG HFSTVWLCWD MQGKRFVAMK VVKSAQHYTE 120
TALDEIKLLK CVRESDPSDP NKDMVVQLID DFKISGMNGI HVCMVFEVLG HHLLKWIIKS 180
NYQGLPVRCV KSIIRQVLQG LDYLHSKCKI IHTDIKPENI LMCVDDAYVR RMAAEATEWQ 240
KAGAPPPSGS AVSTAPQQKP IGKISKNKKK KLKKKQKRQA ELLEKRLQEI EELEREAERK 300
IIEENITSAA PSNDQDGEYC PEVKLKTTGL EEAAEAETAK DNGEAEDQEE KEDAEKENIE 360
KDEDDVDQEL ANIDPTWIES PKTNGHIENG PFSLEQQLDD EDDDEEDCPN PEEYNLDEPN 420
AESDYTYSSS YEQFNGELPN GRHKIPESQF PEFSTSLFSG SLEPVACGSV LSEGSPLTEQ 480
EESSPSHDRS RTVSASSTGD LPKAKTRAAD LLVNPLDPRN ADKIRVKIAD LGNACWVHKH 540
FTEDIQTRQY RSIEVLIGAG YSTPADIWST ACMAFELATG DYLFEPHSGE DYSRDEDHIA 600
HIIELLGSIP RHFALSGKYS REFFNRRGEL RHITKLKPWS LFDVLVEKYG WPHEDAAQFT 660
DFLIPMLEMV PEKRASAGEC LRHPWLNS 689

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationAlzheimer's diseasetumor tissuePT49223197718
[Reference]: In search for new SRPK2 functions in the nervous system, we found that the activity of SRPK2 (as revealed by T492 phosphorylation) (Jang et al., 2009) was significantly increased in the brain of APP/PS1 transgenic mouse, an established animal model of AD that overexpresses mutant forms of amyloid precursor protein (APP) and presenilin (PS) (Trinchese et al., 2004), than the age-matched wild-type control

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 23)
(view all)		rs6968355; Myopia (pathological); myopia
rs2299300; Multiple complex diseases; Null
rs2237606; Body Mass Index; obesity
rs111622941; Body Mass Index; obesity
rs111622941; Waist Circumference; obesity
rs111622941; Insulin Resistance; type 2 diabetes mellitus

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 33)
(view all)		 10        VNSEKSSSSERPEPQ     dbPAF
11        NSEKSSSSERPEPQQ     dbPAF
182       KWIIKSNYQGLPVRC     dbPAF
2         ******MSVNSEKSS     dbPAF
228       LMCVDDAYVRRMAAE     dbPAF
248       KAGAPPPSGSAVSTA     dbPAF
Acetylation
(count: 5)		 110       GKRFVAMKVVKSAQH     PLMD
127       ETALDEIKLLKCVRE     PLMD
324       GEYCPEVKLKTTGLE     PLMD
539       GNACWVHKHFTEDIQ     PLMD
618       RHFALSGKYSREFFN     PLMD
Ubiquitination
(count: 14)
(view all)		 179       HLLKWIIKSNYQGLP     PLMD
209       DYLHSKCKIIHTDIK     PLMD
216       KIIHTDIKPENILMC     PLMD
241       AEATEWQKAGAPPPS     PLMD
259       VSTAPQQKPIGKISK     PLMD
285       RQAELLEKRLQEIEE     PLMD
Sumoylation
(count: 1)		 273       KNKKKKLKKKQKRQA     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource