P70313

※ Protein Information

Tag	Content
UniProt Accession	NOS3_MOUSE; P70313;
Entrez ID	18127
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Nitric oxide synthase, endothelial (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (Endothelial NOS) (eNOS) (NOS type III) (NOSIII)
Gene Name	Nos3; Ecnos
Organism	Mus musculus
NCBI Taxa ID	10090
Functional Description	Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. May play a significant role in normal and abnormal limb development. Functional Description Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. May play a significant role in normal and abnormal limb development.
Sequence (Fasta)	MGNLKSVGQE PGPPCGLGLG LGLGLCGKQG PASPAPEPSQ APAPPSPTRP APDHSPPLTR 60 PPDGPRFPRV KNWEVGSITY DTLSAQAQQD GPCTSRRCLG SLVFPRKLQS RPTQGPSPTE 120 QLLGQARDFI NQYYNSIKRS GSQAHEQRLQ EVEAEVAATG TYQLRESELV FGAKQAWRNA 180 PRCVGRIQWG KLQVFDARDC RTAQEMFTYI CNHIKYATNR GNLRSAITVF PQRCPGRGDF 240 RIWNSQLIRY AGYRQQDGSV RGDPANVEIT ELCIQHGWTP GNGRFDVLPL LLQAPDEPPE 300 LFTLPPEMVL EVPLEHPTLE WFAALGLRWY ALPAVSNMLL EIGGLEFPAA PFSGWYMSSE 360 IGMRDLCDPH RYNILEDVAV CMDLDTRTTS SLWKDKAAVE INVAVLHSYQ LAKVTIVDHH 420 AATASFMKHL ENEQKARGGC PADWAWIVPP ISGSLTPVFH QEMVNYFLSP AFRYQPDPWK 480 GSAAKGAGIT RKKTFKEVAN AVKISASLMG TVMAKRVKAT ILYGSETGRA QSYAQQLGRL 540 FRKAFDPRVL CMDEYDVVSL EHEALVLVVT STFGNGDPPE NGESFAAALM EMSGPYNSSP 600 RPEQHKSYKI RFNSVSCSDP LVSSWRRKRK ESSNTDSAGA LGTLRFCVFG LGSRAYPHFC 660 AFARAVDTRL EELGGERLLQ LGQGDELCGQ EEAFRGWAQA AFQAACETFC VGEDAKAAAR 720 DIFSPKRSWK RQRYRLSTQA ESLQLLPGLT HVHRRKMFQA TILSVENLQS SKSTRATILV 780 RLDTGGQEGL QYQPGDHIGV CPPNRPGLVE ALLSRVEDPP PSTEPVAVEQ LEKGSPGGPP 840 PGWVRDPRLP PCTLRQALTY FLDITSPPSP RLLRLLSTLA EESSEQQELE ALSQDPRRYE 900 EWKWFSCPTL LEVLEQFPSV ALPAPLILTQ LPLLQPRYYS VSSAPSAHPG EIHLTIAVLA 960 YRTQDGLGPL HYGVCSTWMS QLKAGDPVPC FIRGAPSFRL PPDPNLPCIL VGPGTGIAPF 1020 RGFWQDRLHD IEIKGLQPAP MTLVFGCRCS QLDHLYRDEV LDAQQRGVFG QVLTAFSRDP 1080 GSPKTYVQDL LRTELAAEVH RVLCLEQGHM FVCGDVTMAT SVLQTVQRIL ATEGGMELDE 1140 AGDVIGVLRD QQRYHEDIFG LTLRTQEVTS RIRTQSFSLQ ERQLRGAVPW SFDPPGPEIP 1200 GS 1203 Fasta Sequence >P70313\|Nos3; Ecnos\|Mus musculus (Mouse) MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSQAPAPPSPTRPAPDHSPPLTRPPDGPRFPRVKNWEVGSITYDTLSAQAQQDGPCTSRRCLGSLVFPRKLQSRPTQGPSPTEQLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDFRIWNSQLIRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPELFTLPPEMVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSEIGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSTQAESLQLLPGLTHVHRRKMFQATILSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYEEWKWFSCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTIAVLAYRTQDGLGPLHYGVCSTWMSQLKAGDPVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPFRGFWQDRLHDIEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDPGSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGGMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWSFDPPGPEIPGS

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Atherosclerosis		D	S1178	17982133
1	[Reference]: Relative reduction of endothelial nitric-oxide synthase expression and transcription in atherosclerosis-prone regions of the mouse aorta and in an in vitro model of disturbed flow.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 58) (view all)	MESH:D000037 ; Abruptio Placentae MESH:D058186 ; Acute Kidney Injury MESH:D000230 ; Adenocarcinoma MESH:D000544 ; Alzheimer Disease MESH:D001161 ; Arteriosclerosis MESH:D050197 ; Atherosclerosis MESH:D001281 ; Atrial Fibrillation MESH:D001943 ; Breast Neoplasms MESH:D006332 ; Cardiomegaly MESH:D002318 ; Cardiovascular Diseases MESH:D002544 ; Cerebral Infarction MESH:D002971 ; Cleft Lip MESH:D002972 ; Cleft Palate MESH:D003324 ; Coronary Artery Disease MESH:D003329 ; Coronary Vasospasm MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D003922 ; Diabetes Mellitus, Type 1 MESH:D003924 ; Diabetes Mellitus, Type 2 MESH:D003925 ; Diabetic Angiopathies MESH:D003928 ; Diabetic Nephropathies MESH:D020345 ; Enterocolitis, Necrotizing MESH:D007172 ; Erectile Dysfunction MESH:D004938 ; Esophageal Neoplasms MESH:D005317 ; Fetal Growth Retardation MESH:D006333 ; Heart Failure MESH:D006548 ; Hernia, Diaphragmatic MESH:D006943 ; Hyperglycemia MESH:D006946 ; Hyperinsulinism MESH:D006949 ; Hyperlipidemias MESH:D006973 ; Hypertension MESH:D006975 ; Hypertension, Portal MESH:D046110 ; Hypertension, Pregnancy-Induced MESH:D006976 ; Hypertension, Pulmonary MESH:D006978 ; Hypertension, Renovascular MESH:D000860 ; Hypoxia MESH:D007248 ; Infertility, Male MESH:D007333 ; Insulin Resistance MESH:D007416 ; Intestinal Perforation MESH:D007511 ; Ischemia MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D024821 ; Metabolic Syndrome MESH:D009203 ; Myocardial Infarction MESH:D017202 ; Myocardial Ischemia MESH:D015428 ; Myocardial Reperfusion Injury MESH:D009369 ; Neoplasms MESH:D011225 ; Pre-Eclampsia MESH:D011471 ; Prostatic Neoplasms MESH:D029424 ; Pulmonary Disease, Chronic Obstructive MESH:D011654 ; Pulmonary Edema MESH:D015427 ; Reperfusion Injury MESH:D018805 ; Sepsis MESH:D013274 ; Stomach Neoplasms MESH:D013276 ; Stomach Ulcer MESH:D017180 ; Tachycardia, Ventricular MESH:D014511 ; Uremia MESH:D014517 ; Ureteral Obstruction MESH:D018879 ; Ventricular Premature Complexes MESH:D015837 ; Vestibular Diseases

Database

Annotation

CTD (Curated)
(count: 58)
(view all)

MESH:D000037 ; Abruptio Placentae
MESH:D058186 ; Acute Kidney Injury
MESH:D000230 ; Adenocarcinoma
MESH:D000544 ; Alzheimer Disease
MESH:D001161 ; Arteriosclerosis
MESH:D050197 ; Atherosclerosis

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 16) (view all)	1174 EVTSRIRTQSFSLQE dbPAF 1176 TSRIRTQSFSLQERQ dbPAF 1178 RIRTQSFSLQERQLR dbPAF 46 SQAPAPPSPTRPAPD dbPAF 48 APAPPSPTRPAPDHS dbPAF 482 QPDPWKGSAAKGAGI dbPAF 494 AGITRKKTFKEVANA dbPAF 55 TRPAPDHSPPLTRPP dbPAF 59 PDHSPPLTRPPDGPR dbPAF 614 SYKIRFNSVSCSDPL dbPAF 616 KIRFNSVSCSDPLVS dbPAF 623 SCSDPLVSSWRRKRK dbPAF 624 CSDPLVSSWRRKRKE dbPAF 632 WRRKRKESSNTDSAG dbPAF 635 KRKESSNTDSAGALG dbPAF 656 FGLGSRAYPHFCAFA dbPAF

PTM

Modification Sites

Phosphorylation
(count: 16)
(view all)

1174      EVTSRIRTQSFSLQE     dbPAF
1176      TSRIRTQSFSLQERQ     dbPAF
1178      RIRTQSFSLQERQLR     dbPAF
46        SQAPAPPSPTRPAPD     dbPAF
48        APAPPSPTRPAPDHS     dbPAF
482       QPDPWKGSAAKGAGI     dbPAF

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites