P70288

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	HDAC2_MOUSE; P70288;
Entrez ID	15182
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Histone deacetylase 2 (HD2) (EC 3.5.1.98) (YY1 transcription factor-binding protein)
Gene Name	Hdac2; Yy1bp
Organism	Mus musculus
NCBI Taxa ID	10090
Functional Description	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcrip(view all) Functional Description Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Sequence (Fasta)	MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA 60 TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA 120 GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH 180 GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ 240 IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVAK TFNLPLLMLG 300 GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM 360 EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE 420 FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDPKGA 480 KSEQLSNP 489 Fasta Sequence >P70288\|Hdac2; Yy1bp\|Mus musculus (Mouse) MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVAKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDPKGAKSEQLSNP

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Heart failure		U	S394	21576649
1	[Reference]: Phosphorylation of HDAC2 S394 is required for the development of cardiac hypertrophy.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 8) (view all)	MESH:D002294 ; Carcinoma, Squamous Cell MESH:D006332 ; Cardiomegaly MESH:D004715 ; Endometriosis MESH:D007951 ; Leukemia, Myeloid MESH:D008103 ; Liver Cirrhosis MESH:D008545 ; Melanoma MESH:D053842 ; Microsatellite Instability MESH:D029424 ; Pulmonary Disease, Chronic Obstructive

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 10) (view all)	349 FKLHISPSNMTNQNT dbPAF 352 HISPSNMTNQNTPEY dbPAF 356 SNMTNQNTPEYMEKI dbPAF 359 TNQNTPEYMEKIKQR dbPAF 394 EDAVHEDSGDEDGED dbPAF 4 ****MAYSQGGGKKK dbPAF 407 EDPDKRISIRASDKR dbPAF 411 KRISIRASDKRIACD dbPAF 422 IACDEEFSDSEDEGE dbPAF 424 CDEEFSDSEDEGEGG dbPAF
Acetylation (count: 4)	221 DIGAGKGKYYAVNFP PLMD 451 KARIEEDKKETEDKK PLMD 481 KTDPKGAKSEQLSNP PLMD 75 YHSDEYIKFLRSIRP PLMD
Ubiquitination (count: 2)	243 ESYGQIFKPIISKVM PLMD 75 YHSDEYIKFLRSIRP PLMD