P68433

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	H31_MOUSE; P68433;
Entrez ID	97908
GenBank Protein ID	NM_013550.5; NM_145073.2; NM_178206.2; NM_178207.2;
GenBank Nucleotide ID	NP_038578.2; NP_659539.1; NP_835513.1; NP_835514.1;
Protein Name	Histone H3.1
Gene Name	Hist1h3a; H3a;; Hist1h3g; H3.1-221; H3g;; Hist1h3h; H3.1-291; H3h;; Hist1h3i; H3.1-I; H3i
Organism	Mus musculus
NCBI Taxa ID	10090
Functional Description	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Functional Description Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence (Fasta)	MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR EIRRYQKSTE 60 LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEACEAY LVGLFEDTNL CAIHAKRVTI 120 MPKDIQLARR IRGERA 137 Fasta Sequence >P68433\|Hist1h3a; H3a;; Hist1h3g; H3.1-221; H3g;; Hist1h3h; H3.1-291; H3h;; Hist1h3i; H3.1-I; H3i\|Mus musculus (Mouse) MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Alzheimer's disease		D	S58	26199864
1	[Reference]: T58 phosphorylation was decreased by 45%, and doubly phosphorylated S57pT58p was decreased by 30% in 5XFAD brain in comparison to C57BL/6J age- and sex-matched wild type controls.?

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 10) (view all)	100 LQEACEAYLVGLFED dbPAF 11 TKQTARKSTGGKAPR dbPAF 12 KQTARKSTGGKAPRK dbPAF 29 ATKAARKSAPATGGV dbPAF 4 ****MARTKQTARKS dbPAF 46 PHRYRPGTVALREIR dbPAF 55 ALREIRRYQKSTELL dbPAF 58 EIRRYQKSTELLIRK dbPAF 59 IRRYQKSTELLIRKL dbPAF 81 EIAQDFKTDLRFQSS dbPAF
Acetylation (count: 7) (view all)	10 RTKQTARKSTGGKAP PLMD 19 TGGKAPRKQLATKAA PLMD 24 PRKQLATKAARKSAP PLMD 28 LATKAARKSAPATGG PLMD 37 APATGGVKKPHRYRP PLMD 38 PATGGVKKPHRYRPG PLMD 5 ***MARTKQTARKST PLMD
Crotonylation (count: 6)	10 RTKQTARKSTGGKAP PLMD 19 TGGKAPRKQLATKAA PLMD 24 PRKQLATKAARKSAP PLMD 28 LATKAARKSAPATGG PLMD 5 ***MARTKQTARKST PLMD 57 REIRRYQKSTELLIR PLMD
Malonylation (count: 2)	19 TGGKAPRKQLATKAA PLMD 24 PRKQLATKAARKSAP PLMD
Methylation (count: 6)	10 RTKQTARKSTGGKAP PLMD 19 TGGKAPRKQLATKAA PLMD 24 PRKQLATKAARKSAP PLMD 28 LATKAARKSAPATGG PLMD 37 APATGGVKKPHRYRP PLMD 5 ***MARTKQTARKST PLMD
Succinylation (count: 2)	24 PRKQLATKAARKSAP PLMD 28 LATKAARKSAPATGG PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

MINT