P68431

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession H31_HUMAN; P68431;
Entrez ID 8350
GenBank Protein ID NM_003529.2; NM_003530.4; NM_003531.2; NM_003532.2; NM_003533.2; NM_003534.2; NM_003535.2; NM_003536.2; NM_003537.3; NM_021018.2;
GenBank Nucleotide ID NP_003520.1; NP_003521.2; NP_003522.1; NP_003523.1; NP_003524.1; NP_003525.1; NP_003526.1; NP_003527.1; NP_003528.1; NP_066298.1;
Protein Name Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene Name HIST1H3A; H3FA;; HIST1H3B; H3FL;; HIST1H3C; H3FC;; HIST1H3D; H3FB;; HIST1H3E; H3FD;; HIST1H3F; H3FI;; HIST1H3G; H3FH;; HIST1H3H; H3FK;; HIST1H3I; H3FF;; HIST1H3J; H3FJ
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence
(Fasta)		MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR EIRRYQKSTE 60
LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEACEAY LVGLFEDTNL CAIHAKRVTI 120
MPKDIQLARR IRGERA 137

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1AcetylationAcute myeloid leukaemia/Acute myelogenous leukemiaA15514006
[Reference]: Present studies show that LBH589, a novel cinnamic hydroxamic acid analog histone deacetylase inhibitor, induces acetylation of histone H3 and H4 and of heat shock protein 90 (hsp90), increases p21 levels, as well as induces cell-cycle G(1) phase accumulation and apoptosis of the human chronic myeloid leukemia blast crisis (CML-BC) K562 cells and acute leukemia MV4-11 cells with the activating length mutation of FLT-3.
2PhosphorylationProstate cancer/carcinoma/adenocarcinomaU23887713
[Reference]: Prostate cancer tissue exhibited a significantly higher frequency of pHH3-positive cells compared to benign prostate tissue
3Lysine MethylationCancersPK424676717
[Reference]: Aberrant H3K4 methylation promotes carcinogenesis
4Lysine MethylationBreast cancer/tumor/carcinomaMCF7 cell linePK424189459
[Reference]: Histone methyltransferase SMYD3 promotes MRTF-A-mediated transactivation of MYL9 and migration of MCF-7 breast cancer cells.
5Lysine MethylationHepatocellular carcinoma/Hepatocarcinoma/HepatomaPK424740829
[Reference]: miR-302-mediated iPSC technology reprogrammed HCC cells and improved drug sensitivity through AOF2 down-regulation, which caused H3K4 methylation and c-Myc repression
6Lysine MethylationAcute myeloid leukaemia/Acute myelogenous leukemiaPK424235145; 3887211
[Reference]: The mixed lineage leukemia-1 (MLL1) core complex predominantly catalyzes mono- and dimethylation of histone H3 at lysine 4 (H3K4) and is frequently altered in aggressive acute leukemias
7Lysine MethylationProstate cancer/carcinoma/adenocarcinomaPK424793694
[Reference]: Together, these results identify WDR5 as a critical epigenomic integrator of histone phosphorylation and methylation and as a major driver of androgen-dependent prostate cancer cell proliferation
8Lysine MethylationHuntington's diseasePK423872847
[Reference]: We observed gene-specific changes in histone H3 lysine 4 trimethylation (H3K4me3) at transcriptionally repressed promoters in R6/2 mouse and human HD brain
9Lysine MethylationImmune thrombocytopeniaUK424433164
[Reference]: The results showed that global histone H3K9 hypomethylation in CD4+ T cells of active ITP, compared with ITP in remission and controls, while the global histone H3K4 methylation were not significantly different between ITP patients and healthy controls
10Lysine MethylationPancreatic cancer/carcinoma/adenocarcinomaPK516721789
[Reference]: In summary, ChIP region 5 showed clear differences between PANC1 and BxPC3 cells in H3-K4 methylation, H3-K9 methyla-tion, H3-K9 acetylation and H3-K27 acetylation.
11Lysine MethylationColon cancer/carcinomaPK923557258
[Reference]: Cancer-associated upregulation of histone H3 lysine 9 trimethylation promotes cell motility in vitro and drives tumor formation in vivo
12Lysine MethylationRenal cell carcinomaUK922399607
[Reference]: Comparing the global H3K9 methylation levels of benign renal tissue with RCC H3K9me1 (histone H3 lysine 9 mono-methylation) (p<0.001), H3K9me2 (histone H3 lysine 9 di-methylation) (p=0.001) and H3K9me3 (histone H3 lysine 9 tri-methylation) (p<0.001) was significantly over-expressed in benign renal tissue
13Lysine MethylationPrimary human acute leukemiaUK922747680
[Reference]: We found that methylation of histone H3K4 was virtually undetectable, while methylation at H3K9 was significantly higher in primary human leukemia cells
14AcetylationPancreatic cancer/carcinoma/adenocarcinomaPK1016721789
[Reference]: In summary, ChIP region 5 showed clear differences betweenPANC1 and BxPC3 cells in H3-K4 methylation, H3-K9 methyla-tion, H3-K9 acetylation and H3-K27 acetylation.
15Lysine MethylationCervical cancer/carcinomaPK1024292684
[Reference]: Our experiments unveiled a coordinated action between histone ubiquitination/methylation and DNA methylation in transcription repression, providing a mechanism for CUL4B in tumorigenesis
16Lysine MethylationBladder cancerPK1024556868
[Reference]: We observed furthermore a correlation of histone methylation levels with pT stage (H3K9me1, H3K9me2, H3K9me3, H3K27me1, H3K27me3) and grade (H3K9me2, H3K9me3, H3K27me1) in NMIBC
17Serine PhosphorylationCarcinogenesis of nasopharyngeal carcinomacell linePS1123496845
[Reference]: Increased phosphorylation of histone H3 at serine 10 is involved in Epstein-Barr virus latent membrane protein-1-induced carcinogenesis of nasopharyngeal carcinoma
18Serine PhosphorylationHepatocellular carcinoma/Hepatocarcinoma/HepatomaHuh-7 cell linePS1121299907
[Reference]: Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells
19Serine PhosphorylationBrain malignant gliomaGBM 8401 cell linePS1121299907
[Reference]: Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells
20Serine PhosphorylationBladder cancerUS1124115089
[Reference]: In the present study, we found that the expression levels of two epigenetic markers, histone H3K27 trimethylation (H3K27me3), was low but histone H3S10 phosphorylation (pH3Ser10) was high in human bladder cancer tissues, which showed opposite expression patterns in their normal counterparts.
21Serine PhosphorylationColon cancer/carcinomaUS1112234980
[Reference]: Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability.
22Threonine PhosphorylationProstate cancer/carcinoma/adenocarcinomaPT1224793694
[Reference]: Together, these results identify WDR5 as a critical epigenomic integrator of histone phosphorylation and methylation and as a major driver of androgen-dependent prostate cancer cell proliferation
23Lysine MethylationLung cancer/carcinomaPK2724132606
[Reference]: RNA interfering and pharmacologic inhibition of EZH2 reduced histone H3 lysine 27 tri-methylation level and increased TIMP-3 expression level. Knockdown of EZH2 by siRNA significantly reduced A549 cancer cell migration
24Lysine MethylationCancersPK2824767850
[Reference]: EZH2 is the core subunit of Polycomb repressive complex 2 catalyzing the methylation of histone H3 lysine-27 and closely involved in tumorigenesis
25AcetylationPancreatic cancer/carcinoma/adenocarcinomaPK2816721789
[Reference]: In summary, ChIP region 5 showed clear differences betweenPANC1 and BxPC3 cells in H3-K4 methylation, H3-K9 methyla-tion, H3-K9 acetylation and H3-K27 acetylation.
26Lysine MethylationBladder cancerPK2824556868
[Reference]: We observed furthermore a correlation of histone methylation levels with pT stage (H3K9me1, H3K9me2, H3K9me3, H3K27me1, H3K27me3) and grade (H3K9me2, H3K9me3, H3K27me1) in NMIBC
27Lysine MethylationObesityUK2827151441
[Reference]: S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis.
28Lysine MethylationBreast cancer/tumor/carcinomaUK2827494834
[Reference]: Sites correlated and low expression associates with better survival in human breast cancers
29Serine PhosphorylationHepatocellular carcinoma/Hepatocarcinoma/HepatomaHuh-7 cell linePS2921299907
[Reference]: Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells
30Serine PhosphorylationColon cancer/carcinomaSW620 cell linePS2921299907
[Reference]: Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells
31Serine PhosphorylationBrain malignant gliomaGBM 8401 cell linePS2921299907
[Reference]: Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells
32Tyrosine PhosphorylationGlioblastomaUY4225553095
[Reference]: To remedy at this situation, we analyzed the phosphorylation level of histone H3 at the residues T3, T6, S10, S28, Y41 and T45 in a collection of 42 glioblastoma multiformes (GBM). Our data indicated that the high level of pH3T6, pH3S10 and pH3Y41 are signatures associated with a poor prognosis of overall survival (OS) of GBM treated with the "temozolomide and irradiation standard" treatment of GBM (named TMZ+Irad treatment).?
33Lysine MethylationLeukemiaPK8024854991
[Reference]: Recently, DOT1L has also been implicated in the development of MLL-rearranged leukemia, where mistargeting of DOT1L causes aberrant H3K79 methylation at homeobox genes
34Lysine MethylationMelanomaUK8023227340
[Reference]: H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma.


※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 17)
(view all)		 100       LQEACEAYLVGLFED     dbPAF
108       LVGLFEDTNLCAIHA     dbPAF
11        TKQTARKSTGGKAPR     dbPAF
119       AIHAKRVTIMPKDIQ     dbPAF
12        KQTARKSTGGKAPRK     dbPAF
29        ATKAARKSAPATGGV     dbPAF
Acetylation
(count: 13)
(view all)		 10        RTKQTARKSTGGKAP     PLMD
116       NLCAIHAKRVTIMPK     PLMD
123       KRVTIMPKDIQLARR     PLMD
15        ARKSTGGKAPRKQLA     PLMD
19        TGGKAPRKQLATKAA     PLMD
24        PRKQLATKAARKSAP     PLMD
Ubiquitination
(count: 11)
(view all)		 116       NLCAIHAKRVTIMPK     PLMD
123       KRVTIMPKDIQLARR     PLMD
15        ARKSTGGKAPRKQLA     PLMD
19        TGGKAPRKQLATKAA     PLMD
24        PRKQLATKAARKSAP     PLMD
28        LATKAARKSAPATGG     PLMD
Sumoylation
(count: 5)		 19        TGGKAPRKQLATKAA     PLMD
24        PRKQLATKAARKSAP     PLMD
28        LATKAARKSAPATGG     PLMD
57        REIRRYQKSTELLIR     PLMD
80        REIAQDFKTDLRFQS     PLMD
Butyrylation
(count: 7)
(view all)		 10        RTKQTARKSTGGKAP     PLMD
15        ARKSTGGKAPRKQLA     PLMD
19        TGGKAPRKQLATKAA     PLMD
24        PRKQLATKAARKSAP     PLMD
28        LATKAARKSAPATGG     PLMD
5         ***MARTKQTARKST     PLMD
Crotonylation
(count: 6)		 10        RTKQTARKSTGGKAP     PLMD
19        TGGKAPRKQLATKAA     PLMD
24        PRKQLATKAARKSAP     PLMD
28        LATKAARKSAPATGG     PLMD
5         ***MARTKQTARKST     PLMD
57        REIRRYQKSTELLIR     PLMD
Malonylation
(count: 3)		 123       KRVTIMPKDIQLARR     PLMD
57        REIRRYQKSTELLIR     PLMD
80        REIAQDFKTDLRFQS     PLMD
Methylation
(count: 12)
(view all)		 10        RTKQTARKSTGGKAP     PLMD
123       KRVTIMPKDIQLARR     PLMD
15        ARKSTGGKAPRKQLA     PLMD
19        TGGKAPRKQLATKAA     PLMD
24        PRKQLATKAARKSAP     PLMD
28        LATKAARKSAPATGG     PLMD
Propionylation
(count: 1)		 24        PRKQLATKAARKSAP     PLMD
Succinylation
(count: 4)		 123       KRVTIMPKDIQLARR     PLMD
15        ARKSTGGKAPRKQLA     PLMD
57        REIRRYQKSTELLIR     PLMD
80        REIAQDFKTDLRFQS     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
A8MW92P68431MINT
E7ENL6P68431BioGRID
F5H146P68431BioGRID
H0YFJ6P68431BioGRID
O00257P68431DIP
O14744P68431MINT
O14929P68431DIP; IntAct
O15265P68431IntAct
O15315P68431HPRD; MINT
O43463P68431HPRD; IntAct
O43918P68431MINT
O60341P68431DIP
O75164P68431IntAct; MINT
O95503P68431DIP
O95931P68431DIP
P00533P68431IntAct
P05771P68431DIP
P06748P68431DIP
P09874P68431DIP
P11168P68431BioGRID
P12956P68431DIP
P13010P68431DIP
P23258P68431BioGRID
P23921P68431BioGRID
P35659P68431IntAct
P45973P68431MINT
P49321P68431DIP; IntAct;HPRD
P49450P68431HPRD
P51858P68431IntAct
P61964P68431MINT
P62333P68431BioGRID
P62805P68431DIP; IntAct
P62993P68431IntAct; MINT
P68431P68431HPRD
P68431P78527DIP
P68431P83916HPRD; IntAct; MINT
P68431Q03164IntAct
P68431Q09028DIP; IntAct
P68431Q12888MINT
P68431Q13111HPRD; DIP; IntAct; MINT
P68431Q13112HPRD; DIP; IntAct; MINT
P68431Q13185MINT
P68431Q14508BioGRID
P68431Q14781DIP
P68431Q15047HPRD
P68431Q16576DIP; IntAct
P68431Q7Z7M0BioGRID
P68431Q8N806IntAct
P68431Q8TC56BioGRID
P68431Q8TEX9IntAct
P68431Q8WTS6IntAct
P68431Q8WXX5IntAct
P68431Q96ES7MINT
P68431Q96GD4HPRD
P68431Q96T88HPRD; MINT
P68431Q99549MINT
P68431Q9BVI0MINT
P68431Q9HC52DIP
P68431Q9HC84BioGRID
P68431Q9NPI1MINT
P68431Q9NVP2HPRD; IntAct
P68431Q9UGL1DIP
P68431Q9UNP9IntAct
P68431Q9Y232MINT
P68431Q9Y294HPRD; IntAct
P68431Q9Y3T9IntAct
P68431Q9Y468MINT