P67870

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession CSK2B_HUMAN; P67870;
Entrez ID 1460
GenBank Protein ID NM_001282385.1; NM_001320.6;
GenBank Nucleotide ID NP_001269314.1; NP_001311.3;
Protein Name Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a)
Gene Name CSNK2B; CK2N; G5A
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionParticipates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
Sequence
(Fasta)		MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL DMILDLEPDE 60
ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK YQQGDFGYCP RVYCENQPML 120
PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA 180
NQFVPRLYGF KIHPMAYQLQ LQAASNFKSP VKTIR 216

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationLymphocytic leukemiaUS20920576813
[Reference]: CK2beta pSer-209 subunit, which is involved in the regulation of CK2 activity and target binding,37 is highly expressed in CLL samples.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)		MESH:D002294 ; Carcinoma, Squamous Cell
MESH:D015459 ; Leukemia-Lymphoma, Adult T-Cell
MESH:D012878 ; Skin Neoplasms
DisGeNet (Curated)
(count: 3)		C0007137; Squamous cell carcinoma
C0023493; Adult T-Cell Lymphoma/Leukemia
C0037286; Skin Neoplasms
GWASdb
(count: 1)		rs9267531; Rheumatoid arthritis; rheumatoid arthritis

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 16)
(view all)		 108       YQQGDFGYCPRVYCE     dbPAF
11        SEEVSWISWFCGLRG     dbPAF
144       CPKCMDVYTPKSSRH     dbPAF
145       PKCMDVYTPKSSRHH     dbPAF
148       MDVYTPKSSRHHHTD     dbPAF
149       DVYTPKSSRHHHTDG     dbPAF
Acetylation
(count: 4)		 100       GIAQMLEKYQQGDFG     PLMD
139       MVKLYCPKCMDVYTP     PLMD
147       CMDVYTPKSSRHHHT     PLMD
212       SNFKSPVKTIR****     PLMD
Ubiquitination
(count: 8)
(view all)		 100       GIAQMLEKYQQGDFG     PLMD
134       IPGEAMVKLYCPKCM     PLMD
139       MVKLYCPKCMDVYTP     PLMD
147       CMDVYTPKSSRHHHT     PLMD
191       VPRLYGFKIHPMAYQ     PLMD
208       LQAASNFKSPVKTIR     PLMD
Sumoylation
(count: 1)		 212       SNFKSPVKTIR****     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource