| Tag | Content |
|---|---|
| UniProt Accession | YBOX1_HUMAN; P67809; |
| Entrez ID | 4904 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Nuclease-sensitive element-binding protein 1 (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Y-box transcription factor) (Y-box-binding protein 1) (YB-1) |
| Gene Name | YBX1; NSEP1; YB1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro.;The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation. |
| Sequence (Fasta) | MSSEAETQQP PAAPPAAPAL SAADTKPGTT GSGAGSGGPG GLTSAAPAGG DKKVIATKVL 60 GTVKWFNVRN GYGFINRNDT KEDVFVHQTA IKKNNPRKYL RSVGDGETVE FDVVEGEKGA 120 EAANVTGPGG VPVQGSKYAA DRNHYRRYPR RRGPPRNYQQ NYQNSESGEK NEGSESAPEG 180 QAQQRRPYRR RRFPPYYMRR PYGRRPQYSN PPVQGEVMEG ADNQGAGEQG RPVRQNMYRG 240 YRPRFRRGPP RQRQPREDGN EEDKENQGDE TQGQQPPQRR YRRNFNYRRR RPENPKPQDG 300 KETKAADPPA ENSSAPEAEQ GGAE 325 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 4) | MESH:D001943
; Breast Neoplasms MESH:D003110 ; Colonic Neoplasms MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D009364 ; Neoplasm Recurrence, Local |
| GWASdb (count: 1) | rs3895305; Lymphocyte counts; asthma|leukemia|lymphoma|lymphopenia|cardiovascular system disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 31) (view all) | 102 NPRKYLRSVGDGETV dbPAF
108 RSVGDGETVEFDVVE dbPAF 136 GGVPVQGSKYAADRN dbPAF 145 YAADRNHYRRYPRRR dbPAF 158 RRGPPRNYQQNYQNS dbPAF 162 PRNYQQNYQNSESGE dbPAF |
| Acetylation (count: 5) | 137 GVPVQGSKYAADRNH PLMD
170 QNSESGEKNEGSESA PLMD 264 EDGNEEDKENQGDET PLMD 296 RRRPENPKPQDGKET PLMD 58 DKKVIATKVLGTVKW PLMD |
| Ubiquitination (count: 10) (view all) | 137 GVPVQGSKYAADRNH PLMD
170 QNSESGEKNEGSESA PLMD 26 ALSAADTKPGTTGSG PLMD 264 EDGNEEDKENQGDET PLMD 296 RRRPENPKPQDGKET PLMD 301 NPKPQDGKETKAADP PLMD |
| Sumoylation (count: 1) | 26 ALSAADTKPGTTGSG PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |