P63330

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession PP2AA_MOUSE; P63330;
Entrez ID 19052
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16)
Gene Name Ppp2ca
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionPP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).
Sequence
(Fasta)		MDEKLFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60
QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 120
RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 180
RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 240
HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 300
TRRTPDYFL

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationAlzheimer's diseaseUY30718208556
[Reference]: Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)		MESH:D001249 ; Asthma
MESH:D006331 ; Heart Diseases
MESH:D017202 ; Myocardial Ischemia

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 4)		 127       SRQITQVYGFYDECL     dbPAF
284       ELDDTLKYSFLQFDP     dbPAF
304       EPHVTRRTPDYFL**     dbPAF
307       VTRRTPDYFL*****     dbPAF
Ubiquitination
(count: 3)		 21        IEQLNECKQLSESQV     PLMD
29        QLSESQVKSLCEKAK     PLMD
8         MDEKLFTKELDQWIE     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource