Tag | Content |
---|---|
UniProt Accession | UBC9_HUMAN; P63279; |
Entrez ID | 7329 |
GenBank Protein ID | NM_003345.4; NM_194259.2; NM_194260.2; NM_194261.2; XM_017023640.1; |
GenBank Nucleotide ID | NP_003336.1; NP_919235.1; NP_919236.1; NP_919237.1; XP_016879129.1; |
Protein Name | SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) |
Gene Name | UBE2I; UBC9; UBCE9 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. |
Sequence (Fasta) | MSGIALSRLA QERKAWRKDH PFGFVAVPTK NPDGTMNLMN WECAIPGKKG TPWEGGLFKL 60 RMLFKDDYPS SPPKCKFEPP LFHPNVYPSG TVCLSILEED KDWRPAITIK QILLGIQELL 120 NEPNIQDPAQ AEAYTIYCQN RVEYEKRVRA QAKKFAPS 159 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 3) | MESH:D002277
; Carcinoma MESH:D015674 ; Mammary Neoplasms, Animal MESH:D008325 ; Mammary Neoplasms, Experimental |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 4) | 2 ******MSGIALSRL dbPAF
35 PTKNPDGTMNLMNWE dbPAF 70 LFKDDYPSSPPKCKF dbPAF 71 FKDDYPSSPPKCKFE dbPAF |
Acetylation (count: 5) | 146 QNRVEYEKRVRAQAK PLMD
30 GFVAVPTKNPDGTMN PLMD 48 WECAIPGKKGTPWEG PLMD 59 PWEGGLFKLRMLFKD PLMD 65 FKLRMLFKDDYPSSP PLMD |
Ubiquitination (count: 6) | 154 RVRAQAKKFAPS*** PLMD
18 QERKAWRKDHPFGFV PLMD 49 ECAIPGKKGTPWEGG PLMD 59 PWEGGLFKLRMLFKD PLMD 65 FKLRMLFKDDYPSSP PLMD 74 DYPSSPPKCKFEPPL PLMD |
Sumoylation (count: 6) | 101 LSILEEDKDWRPAIT PLMD
14 SRLAQERKAWRKDHP PLMD 146 QNRVEYEKRVRAQAK PLMD 153 KRVRAQAKKFAPS** PLMD 48 WECAIPGKKGTPWEG PLMD 49 ECAIPGKKGTPWEGG PLMD |
Malonylation (count: 1) | 18 QERKAWRKDHPFGFV PLMD |
Succinylation (count: 1) | 65 FKLRMLFKDDYPSSP PLMD |