P63279

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession UBC9_HUMAN; P63279;
Entrez ID 7329
GenBank Protein ID NM_003345.4; NM_194259.2; NM_194260.2; NM_194261.2; XM_017023640.1;
GenBank Nucleotide ID NP_003336.1; NP_919235.1; NP_919236.1; NP_919237.1; XP_016879129.1;
Protein Name SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene Name UBE2I; UBC9; UBCE9
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionAccepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'.
Sequence
(Fasta)
MSGIALSRLA QERKAWRKDH PFGFVAVPTK NPDGTMNLMN WECAIPGKKG TPWEGGLFKL 60
RMLFKDDYPS SPPKCKFEPP LFHPNVYPSG TVCLSILEED KDWRPAITIK QILLGIQELL 120
NEPNIQDPAQ AEAYTIYCQN RVEYEKRVRA QAKKFAPS 159

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationLiver cancertumor tissueUS7122407595
[Reference]: Levels of phospho-Ubc9, total Ubc9, Cdc2 and Cdc2 that interacts with Ubc9 are increased in human colon, liver and breast cancers
2Serine PhosphorylationBreast cancer/tumor/carcinomatumor tissueUS7122407595
[Reference]: Levels of phospho-Ubc9, total Ubc9, Cdc2 and Cdc2 that interacts with Ubc9 are increased in human colon, liver and breast cancers
3Serine PhosphorylationColon cancer/carcinomatumor tissueUS7122407595
[Reference]: Levels of phospho-Ubc9, total Ubc9, Cdc2 and Cdc2 that interacts with Ubc9 are increased in human colon, liver and breast cancers

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)
MESH:D002277 ; Carcinoma
MESH:D015674 ; Mammary Neoplasms, Animal
MESH:D008325 ; Mammary Neoplasms, Experimental

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 4)
2         ******MSGIALSRL     dbPAF
35        PTKNPDGTMNLMNWE     dbPAF
70        LFKDDYPSSPPKCKF     dbPAF
71        FKDDYPSSPPKCKFE     dbPAF
Acetylation
(count: 5)
146       QNRVEYEKRVRAQAK     PLMD
30        GFVAVPTKNPDGTMN     PLMD
48        WECAIPGKKGTPWEG     PLMD
59        PWEGGLFKLRMLFKD     PLMD
65        FKLRMLFKDDYPSSP     PLMD
Ubiquitination
(count: 6)
154       RVRAQAKKFAPS***     PLMD
18        QERKAWRKDHPFGFV     PLMD
49        ECAIPGKKGTPWEGG     PLMD
59        PWEGGLFKLRMLFKD     PLMD
65        FKLRMLFKDDYPSSP     PLMD
74        DYPSSPPKCKFEPPL     PLMD
Sumoylation
(count: 6)
101       LSILEEDKDWRPAIT     PLMD
14        SRLAQERKAWRKDHP     PLMD
146       QNRVEYEKRVRAQAK     PLMD
153       KRVRAQAKKFAPS**     PLMD
48        WECAIPGKKGTPWEG     PLMD
49        ECAIPGKKGTPWEGG     PLMD
Malonylation
(count: 1)
18        QERKAWRKDHPFGFV     PLMD
Succinylation
(count: 1)
65        FKLRMLFKDDYPSSP     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
A6NG32P63279HPRD
A8MT69P63279HPRD
E9PDN9P63279MINT
E9PG89P63279HPRD
G5E9Q2P63279IntAct
H0YFA3P63279IntAct
H7BZT4P63279IntAct
H7C4S0P63279IntAct
O00257P63279HPRD
O00327P63279HPRD
O14503P63279IntAct
O14544P63279IntAct
O14964P63279HPRD; IntAct
O15015P63279IntAct;HPRD
O43255P63279IntAct
O43353P63279HPRD; IntAct
O60291P63279IntAct
O60683P63279IntAct
O60739P63279IntAct
O75030P63279HPRD
O75400P63279MINT;HPRD
O75925P63279HPRD; IntAct
O75928P63279HPRD; IntAct
O94829P63279HPRD; MINT
O95551P63279HPRD
O95817P63279IntAct
O96006P63279HPRD; IntAct
P03372P63279HPRD
P03928P63279IntAct
P04150P63279HPRD
P04637P63279HPRD; DIP; IntAct; MINT
P05412P63279HPRD
P05549P63279IntAct
P07910P63279HPRD; IntAct
P09936P63279HPRD; IntAct
P10242P63279HPRD
P10275P63279HPRD; DIP
P10644P63279IntAct
P11166P63279HPRD
P11387P63279HPRD
P12757P63279HPRD; MINT
P14373P63279IntAct
P14672P63279HPRD
P14921P63279HPRD
P15104P63279IntAct
P15336P63279HPRD
P15923P63279HPRD
P16220P63279IntAct
P19419P63279HPRD; MINT
P19438P63279HPRD
P19544P63279HPRD
P19634P63279IntAct
P22314P63279IntAct
P23497P63279IntAct;HPRD
P25445P63279HPRD
P27540P63279HPRD
P27695P63279HPRD
P29590P63279IntAct
P31321P63279IntAct
P35226P63279IntAct
P36406P63279IntAct
P36956P63279HPRD
P37088P63279HPRD
P41212P63279HPRD; DIP
P41235P63279HPRD
P42224P63279HPRD
P43351P63279HPRD; DIP
P46060P63279HPRD; DIP; IntAct; MINT
P49789P63279HPRD
P49792P63279HPRD; IntAct
P54253P63279HPRD; IntAct; MINT
P55055P63279HPRD
P55854P63279HPRD; IntAct
P56537P63279IntAct
P56545P63279IntAct
P56693P63279HPRD; MINT
P60484P63279HPRD
P61956P63279HPRD
P61978P63279IntAct;HPRD
P62805P63279HPRD
P63165P63279HPRD; DIP; IntAct; MINT
P63279P63279HPRD; IntAct
P63279P78317IntAct
P63279P78364HPRD; IntAct
P63279Q00610IntAct
P63279Q01826HPRD; IntAct
P63279Q02078DIP
P63279Q02447HPRD
P63279Q03060IntAct
P63279Q03933HPRD
P63279Q06265IntAct
P63279Q06609DIP;HPRD
P63279Q06787HPRD
P63279Q06945HPRD
P63279Q09472HPRD
P63279Q12772HPRD; IntAct
P63279Q13064IntAct
P63279Q13422HPRD; IntAct
P63279Q13432HPRD; IntAct
P63279Q13485HPRD; IntAct; MINT
P63279Q13547HPRD
P63279Q13867HPRD
P63279Q14103HPRD; IntAct;IntAct
P63279Q14134HPRD; IntAct
P63279Q14164IntAct
P63279Q14315IntAct
P63279Q14789IntAct
P63279Q14995HPRD
P63279Q15047IntAct
P63279Q15714IntAct
P63279Q15744HPRD
P63279Q15942IntAct
P63279Q5JR12HPRD
P63279Q5JVS0HPRD
P63279Q5T6S3IntAct
P63279Q6UYC3HPRD
P63279Q6ZMU5IntAct
P63279Q6ZNA4IntAct
P63279Q777G9MINT
P63279Q7Z333IntAct
P63279Q7Z419IntAct
P63279Q7Z6E9IntAct
P63279Q86Y13IntAct
P63279Q86Z02IntAct
P63279Q8IVD9HPRD; IntAct
P63279Q8N2W9IntAct
P63279Q8N448IntAct
P63279Q8N4C6HPRD
P63279Q8N5U6IntAct
P63279Q8NDC0HPRD; IntAct
P63279Q8NDV7IntAct
P63279Q8TAD8HPRD; MINT
P63279Q8TDB6IntAct
P63279Q8TEB7IntAct
P63279Q8WV44IntAct
P63279Q8WVZ7IntAct
P63279Q92481HPRD; IntAct
P63279Q92753HPRD
P63279Q92754HPRD; IntAct
P63279Q92905IntAct
P63279Q93068DIP
P63279Q969Q1HPRD
P63279Q969V5MINT
P63279Q969V6HPRD
P63279Q96B23HPRD; IntAct
P63279Q96GF1IntAct
P63279Q96RL1IntAct
P63279Q96S59IntAct
P63279Q99497IntAct
P63279Q99684IntAct
P63279Q99856MINT
P63279Q9BUZ4HPRD
P63279Q9H2X6HPRD; IntAct; MINT
P63279Q9H2Y7IntAct
P63279Q9H307IntAct
P63279Q9H422IntAct
P63279Q9H444HPRD; IntAct
P63279Q9HBD1IntAct
P63279Q9HCE1MINT
P63279Q9NPI1IntAct
P63279Q9NQB0IntAct
P63279Q9NR12HPRD; IntAct
P63279Q9NS56HPRD
P63279Q9NS91IntAct
P63279Q9NSC2HPRD
P63279Q9NVP2IntAct
P63279Q9NX47IntAct
P63279Q9UBC3HPRD; IntAct
P63279Q9UBE0IntAct
P63279Q9UBT2HPRD; IntAct
P63279Q9UBW7IntAct
P63279Q9UER7HPRD; IntAct
P63279Q9UI36IntAct;HPRD
P63279Q9UKD1HPRD
P63279Q9UKL3IntAct
P63279Q9UKT9HPRD; IntAct
P63279Q9UKY1IntAct
P63279Q9ULV8IntAct
P63279Q9Y265DIP
P63279Q9Y3S1IntAct
P63279Q9Y3V2IntAct
P63279Q9Y4E5HPRD; IntAct
P63279Q9Y620HPRD; IntAct
P63279Q9Y692HPRD; IntAct
P63279Q9Y6K1HPRD
P63279Q9Y6X2IntAct