Tag | Content |
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UniProt Accession | MK01_RAT; P63086; |
Entrez ID | 116590 |
GenBank Protein ID | NM_053842.2; XM_006248658.3; XM_006248659.3; XM_008768848.2; |
GenBank Nucleotide ID | NP_446294.1; XP_006248720.1; XP_006248721.1; XP_008767070.1; |
Protein Name | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) |
Gene Name | Mapk1; Erk2; Mapk; Prkm1 |
Organism | Rattus norvegicus |
NCBI Taxa ID | 10116 |
Functional Description | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade p(view all) |
Sequence (Fasta) | MAAAAAAGPE MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA YDNLNKVRVA IKKISPFEHQ 60 TYCQRTLREI KILLRFRHEN IIGINDIIRA PTIEQMKDVY IVQDLMETDL YKLLKTQHLS 120 NDHICYFLYQ ILRGLKYIHS ANVLHRDLKP SNLLLNTTCD LKICDFGLAR VADPDHDHTG 180 FLTEYVATRW YRAPEIMLNS KGYTKSIDIW SVGCILAEML SNRPIFPGKH YLDQLNHILG 240 ILGSPSQEDL NCIINLKARN YLLSLPHKNK VPWNRLFPNA DSKALDLLDK MLTFNPHKRI 300 EVEQALAHPY LEQYYDPSDE PIAEAPFKFD MELDDLPKEK LKELIFEETA RFQPGYRS 359 |
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Database | Annotation |
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CTD (Curated) (count: 27) (view all) | MESH:D001171
; Arthritis, Juvenile MESH:D002545 ; Brain Ischemia MESH:D002294 ; Carcinoma, Squamous Cell MESH:D009202 ; Cardiomyopathies MESH:C566627 ; Ceroid Lipofuscinosis, Neuronal, 6 MESH:D001651 ; Cholestasis, Extrahepatic |
PTM | Modification Sites |
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Phosphorylation (count: 7) (view all) | 179 ADPDHDHTGFLTEYV dbPAF
183 HDHTGFLTEYVATRW dbPAF 185 HTGFLTEYVATRWYR dbPAF 188 FLTEYVATRWYRAPE dbPAF 27 GPRYTNLSYIGEGAY dbPAF 28 PRYTNLSYIGEGAYG dbPAF |
Acetylation (count: 3) | 268 YLLSLPHKNKVPWNR PLMD
283 LFPNADSKALDLLDK PLMD 290 KALDLLDKMLTFNPH PLMD |