| Tag | Content |
|---|---|
| UniProt Accession | IF4E_MOUSE; P63073; |
| Entrez ID | 13684 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit) |
| Gene Name | Eif4e |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. |
| Sequence (Fasta) | MATVEPETTP TTNPPPAEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL 60 RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ 120 QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENRDAVTHIG 180 RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV 218 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 3) | MESH:D001321
; Autistic Disorder MESH:D020522 ; Lymphoma, Mantle-Cell MESH:D009361 ; Neoplasm Invasiveness |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 5) | 207 HADTATKSGSTTKNR dbPAF
209 DTATKSGSTTKNRFV dbPAF 210 TATKSGSTTKNRFVV dbPAF 22 PPAEEEKTESNQEVA dbPAF 24 AEEEKTESNQEVANP dbPAF |
| Acetylation (count: 1) | 119 RWLITLNKQQRRSDL PLMD |
| Ubiquitination (count: 1) | 119 RWLITLNKQQRRSDL PLMD |
| Malonylation (count: 5) | 119 RWLITLNKQQRRSDL PLMD
159 AVVNVRAKGDKIAIW PLMD 162 NVRAKGDKIAIWTTE PLMD 206 SHADTATKSGSTTKN PLMD 54 FFKNDKSKTWQANLR PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |