Tag | Content |
---|---|
UniProt Accession | RAC1_HUMAN; P63000; |
Entrez ID | 5879 |
GenBank Protein ID | NM_006908.4; NM_018890.3; |
GenBank Nucleotide ID | NP_008839.2; NP_061485.1; |
Protein Name | Ras-related C3 botulinum toxin substrate 1 (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1) |
Gene Name | RAC1; TC25; MIG5 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated r(view all) |
Sequence (Fasta) | MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG 60 QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPNTPI ILVGTKLDLR 120 DDKDTIEKLK EKKLTPITYP QGLAMAKEIG AVKYLECSAL TQRGLKTVFD EAIRAVLCPP 180 PVKKRKRKCL LL 193 |
|
Database | Annotation |
---|---|
Cancer Gene Census | melanoma, carcinoma |
CTD (Curated) (count: 10) (view all) | MESH:D006528
; Carcinoma, Hepatocellular MESH:D002311 ; Cardiomyopathy, Dilated MESH:D066126 ; Cardiotoxicity MESH:D002471 ; Cell Transformation, Neoplastic MESH:D003920 ; Diabetes Mellitus MESH:D006333 ; Heart Failure |
GWASdb (count: 11) (view all) | rs2347338; Suicide attempts in bipolar disorder; bipolar disorder
rs10234438; Suicide attempts in bipolar disorder; bipolar disorder rs10238136; Suicide attempts in bipolar disorder; bipolar disorder rs702483; Self-reported allergy; hypersensitivity reaction disease rs836483; Self-reported allergy; hypersensitivity reaction disease rs836480; Self-reported allergy; hypersensitivity reaction disease |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 5) | 108 VRHHCPNTPIILVGT dbPAF
161 YLECSALTQRGLKTV dbPAF 167 LTQRGLKTVFDEAIR dbPAF 64 DTAGQEDYDRLRPLS dbPAF 71 YDRLRPLSYPQTDVF dbPAF |
Acetylation (count: 2) | 147 PQGLAMAKEIGAVKY PLMD
153 AKEIGAVKYLECSAL PLMD |
Ubiquitination (count: 6) | 116 PIILVGTKLDLRDDK PLMD
133 IEKLKEKKLTPITYP PLMD 147 PQGLAMAKEIGAVKY PLMD 153 AKEIGAVKYLECSAL PLMD 183 VLCPPPVKKRKRKCL PLMD 184 LCPPPVKKRKRKCLL PLMD |
Sumoylation (count: 4) | 183 VLCPPPVKKRKRKCL PLMD
184 LCPPPVKKRKRKCLL PLMD 186 PPPVKKRKRKCLLL* PLMD 188 PVKKRKRKCLLL*** PLMD |
Malonylation (count: 1) | 133 IEKLKEKKLTPITYP PLMD |
Methylation (count: 2) | 123 KLDLRDDKDTIEKLK PLMD
130 KDTIEKLKEKKLTPI PLMD |
Succinylation (count: 1) | 147 PQGLAMAKEIGAVKY PLMD |