| Tag | Content |
|---|---|
| UniProt Accession | H2B1C_HUMAN; P62807; |
| Entrez ID | 8347 |
| GenBank Protein ID | NM_003518.3; NM_003522.3; NM_003523.2; NM_003525.2; NM_003526.2; NM_021063.3; |
| GenBank Nucleotide ID | NP_003509.1; NP_003513.1; NP_003514.2; NP_003516.1; NP_003517.2; NP_066407.1; |
| Protein Name | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) |
| Gene Name | HIST1H2BC; H2BFL;; HIST1H2BE; H2BFH;; HIST1H2BF; H2BFG;; HIST1H2BG; H2BFA;; HIST1H2BI; H2BFK |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.;Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Sequence (Fasta) | MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM 60 GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT 120 KYTSSK 127 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D001943 ; Breast Neoplasms |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 11) (view all) | 116 KHAVSEGTKAVTKYT dbPAF
15 APAPKKGSKKAVTKA dbPAF 33 DGKKRKRSRKESYSV dbPAF 37 RKRSRKESYSVYVYK dbPAF 38 KRSRKESYSVYVYKV dbPAF 41 RKESYSVYVYKVLKQ dbPAF |
| Sumoylation (count: 1) | 6 **MPEPAKSAPAPKK PLMD |
| Crotonylation (count: 8) (view all) | 12 AKSAPAPKKGSKKAV PLMD
13 KSAPAPKKGSKKAVT PLMD 16 PAPKKGSKKAVTKAQ PLMD 17 APKKGSKKAVTKAQK PLMD 21 GSKKAVTKAQKKDGK PLMD 24 KAVTKAQKKDGKKRK PLMD |
| Methylation (count: 1) | 6 **MPEPAKSAPAPKK PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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