| Tag | Content |
|---|---|
| UniProt Accession | H4_HUMAN; P62805; |
| Entrez ID | 8359 |
| GenBank Protein ID | NM_001034077.4; NM_003495.2; NM_003538.3; NM_003539.3; NM_003540.3; NM_003541.2; NM_003542.3; NM_003543.3; NM_003544.2; NM_003545.3; NM_003546.2; NM_003548.2; NM_021968.3; NM_175054.2; |
| GenBank Nucleotide ID | NP_001029249.1; NP_003486.1; NP_003529.1; NP_003530.1; NP_003531.1; NP_003532.1; NP_003533.1; NP_003534.1; NP_003535.1; NP_003536.1; NP_003537.1; NP_003539.1; NP_068803.1; NP_778224.1; |
| Protein Name | Histone H4 |
| Gene Name | HIST1H4A; H4/A; H4FA;; HIST1H4B; H4/I; H4FI;; HIST1H4C; H4/G; H4FG;; HIST1H4D; H4/B; H4FB;; HIST1H4E; H4/J; H4FJ;; HIST1H4F; H4/C; H4FC;; HIST1H4H; H4/H; H4FH;; HIST1H4I; H4/M; H4FM;; HIST1H4J; H4/E; H4FE;; HIST1H4K; H4/D; H4FD;; HIST1H4L; H4/K; H4FK;; HIST2H4A; H4/N; H4F2; H4FN; HIST2H4;; HI |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Sequence (Fasta) | MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK 60 VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG FGG 104 |
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| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 11) (view all) | 2 ******MSGRGKGGK dbPAF
31 RDNIQGITKPAIRRL dbPAF 48 RGGVKRISGLIYEET dbPAF 52 KRISGLIYEETRGVL dbPAF 55 SGLIYEETRGVLKVF dbPAF 73 VIRDAVTYTEHAKRK dbPAF |
| Acetylation (count: 10) (view all) | 13 KGGKGLGKGGAKRHR PLMD
17 GLGKGGAKRHRKVLR PLMD 32 DNIQGITKPAIRRLA PLMD 45 LARRGGVKRISGLIY PLMD 6 **MSGRGKGGKGLGK PLMD 60 EETRGVLKVFLENVI PLMD |
| Ubiquitination (count: 6) | 13 KGGKGLGKGGAKRHR PLMD
32 DNIQGITKPAIRRLA PLMD 60 EETRGVLKVFLENVI PLMD 78 VTYTEHAKRKTVTAM PLMD 80 YTEHAKRKTVTAMDV PLMD 92 MDVVYALKRQGRTLY PLMD |
| Sumoylation (count: 5) | 13 KGGKGLGKGGAKRHR PLMD
21 GGAKRHRKVLRDNIQ PLMD 6 **MSGRGKGGKGLGK PLMD 9 SGRGKGGKGLGKGGA PLMD 92 MDVVYALKRQGRTLY PLMD |
| Butyrylation (count: 9) (view all) | 13 KGGKGLGKGGAKRHR PLMD
17 GLGKGGAKRHRKVLR PLMD 32 DNIQGITKPAIRRLA PLMD 45 LARRGGVKRISGLIY PLMD 6 **MSGRGKGGKGLGK PLMD 78 VTYTEHAKRKTVTAM PLMD |
| Crotonylation (count: 3) | 13 KGGKGLGKGGAKRHR PLMD
6 **MSGRGKGGKGLGK PLMD 9 SGRGKGGKGLGKGGA PLMD |
| Malonylation (count: 1) | 80 YTEHAKRKTVTAMDV PLMD |
| Methylation (count: 5) | 21 GGAKRHRKVLRDNIQ PLMD
32 DNIQGITKPAIRRLA PLMD 60 EETRGVLKVFLENVI PLMD 78 VTYTEHAKRKTVTAM PLMD 80 YTEHAKRKTVTAMDV PLMD |
| Propionylation (count: 9) (view all) | 13 KGGKGLGKGGAKRHR PLMD
17 GLGKGGAKRHRKVLR PLMD 32 DNIQGITKPAIRRLA PLMD 45 LARRGGVKRISGLIY PLMD 6 **MSGRGKGGKGLGK PLMD 78 VTYTEHAKRKTVTAM PLMD |
| Neddylation (count: 6) | 13 KGGKGLGKGGAKRHR PLMD
17 GLGKGGAKRHRKVLR PLMD 21 GGAKRHRKVLRDNIQ PLMD 32 DNIQGITKPAIRRLA PLMD 6 **MSGRGKGGKGLGK PLMD 9 SGRGKGGKGLGKGGA PLMD |
| Succinylation (count: 4) | 13 KGGKGLGKGGAKRHR PLMD
32 DNIQGITKPAIRRLA PLMD 78 VTYTEHAKRKTVTAM PLMD 92 MDVVYALKRQGRTLY PLMD |