P62755

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession RS6_RAT; P62755;
Entrez ID 29304
GenBank Protein ID NM_017160.1; XM_003749971.3;
GenBank Nucleotide ID NP_058856.1; XP_003750019.1;
Protein Name 40S ribosomal protein S6
Gene Name Rps6
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional DescriptionMay play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
Sequence
(Fasta)		MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG 60
FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIVKKGEKD 120
IPGLTDTTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV 180
TPRVLQHKRR RIALKKQRTK KNKEEAAEYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS 240
TSKSESSQK

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationAscites hepatomaP2852063
[Reference]: Heat shock, protein synthesis and ribosomal protein S6 phosphorylation in vitro in Yoshida AH 130 ascites hepatoma cells.
2PhosphorylationHepatocellular carcinoma/Hepatocarcinoma/HepatomaU6319390
[Reference]: Tumor-promoting phorbol esters stimulate the phosphorylation of ribosomal protein S6 in quiescent Reuber H35 hepatoma cells.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)		MESH:D001943 ; Breast Neoplasms
MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D018450 ; Disease Progression
MESH:D013274 ; Stomach Neoplasms

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 10)
(view all)		 127       DIPGLTDTTVPRRLG     dbPAF
148       IRKLFNLSKEDDVRQ     dbPAF
235       IAKRRRLSSLRASTS     dbPAF
236       AKRRRLSSLRASTSK     dbPAF
240       RLSSLRASTSKSESS     dbPAF
241       LSSLRASTSKSESSQ     dbPAF
Acetylation
(count: 5)		 149       RKLFNLSKEDDVRQY     PLMD
203       KQRTKKNKEEAAEYA     PLMD
211       EEAAEYAKLLAKRMK     PLMD
30        KLRTFYEKRMATEVA     PLMD
64        DKQGFPMKQGVLTHG     PLMD