P62754

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession RS6_MOUSE; P62754;
Entrez ID 20104
GenBank Protein ID NM_009096.3; XM_011239877.1;
GenBank Nucleotide ID NP_033122.1; XP_011238179.1;
Protein Name 40S ribosomal protein S6 (Phosphoprotein NP33)
Gene Name Rps6
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionMay play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
Sequence
(Fasta)		MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG 60
FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIVKKGEKD 120
IPGLTDTTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV 180
TPRVLQHKRR RIALKKQRTK KNKEEAAEYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS 240
TSKSESSQK

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationMelanomaP6347262
[Reference]: Insulin-mediated phosphorylation of ribosomal protein S6 in mouse melanoma cells and melanoma x fibroblast hybrid cells in relation to cell proliferation.
2PhosphorylationKrebs II ascites tumourU7260893
[Reference]: Increased phosphorylation of a liver ribosomal protein in mice carrying ascites tumours.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)		MESH:D001943 ; Breast Neoplasms
MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D018450 ; Disease Progression
MESH:D013274 ; Stomach Neoplasms

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 11)
(view all)		 127       DIPGLTDTTVPRRLG     dbPAF
148       IRKLFNLSKEDDVRQ     dbPAF
235       IAKRRRLSSLRASTS     dbPAF
236       AKRRRLSSLRASTSK     dbPAF
240       RLSSLRASTSKSESS     dbPAF
241       LSSLRASTSKSESSQ     dbPAF
Acetylation
(count: 10)
(view all)		 119       VIVKKGEKDIPGLTD     PLMD
14        FPATGCQKLIEVDDE     PLMD
143       KRASRIRKLFNLSKE     PLMD
149       RKLFNLSKEDDVRQY     PLMD
2         ******MKLNISFPA     PLMD
203       KQRTKKNKEEAAEYA     PLMD
Ubiquitination
(count: 3)		 143       KRASRIRKLFNLSKE     PLMD
211       EEAAEYAKLLAKRMK     PLMD
58        RISGGNDKQGFPMKQ     PLMD
Malonylation
(count: 3)		 203       KQRTKKNKEEAAEYA     PLMD
211       EEAAEYAKLLAKRMK     PLMD
64        DKQGFPMKQGVLTHG     PLMD
Succinylation
(count: 4)		 116       LNLVIVKKGEKDIPG     PLMD
149       RKLFNLSKEDDVRQY     PLMD
203       KQRTKKNKEEAAEYA     PLMD
46        DALGEEWKGYVVRIS     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource