P62753

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession RS6_HUMAN; P62753;
Entrez ID 6194
GenBank Protein ID
GenBank Nucleotide ID
Protein Name 40S ribosomal protein S6 (Phosphoprotein NP33) (Small ribosomal subunit protein eS6)
Gene Name RPS6; OK/SW-cl.2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMay play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
Sequence
(Fasta)		MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG 60
FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIVKKGEKD 120
IPGLTDTTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV 180
TPRVLQHKRR RIALKKQRTK KNKEEAAEYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS 240
TSKSESSQK

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationEhrlich ascites tumorU208946
[Reference]: Enhanced phosphorylation of ribosomal protein s6 and other cytoplasmic proteins after mengovirus infection of Ehrlich ascites tumor cells.
2PhosphorylationEsophageal squamous cell carcinomatumor tissueU22996377
[Reference]: Here, we show that high level of phosphorylated-ribosomal protein S6 (p-S6) (immunohistochemistry score 5) and an increased ratio of p-S6/S6 (immunohistochemistry score 0.75) were significantly associated with shortened disease-free survival in patients with esophageal squamous cell carcinoma in univariate analysis (P=0.049 and P<0.001, respectively).
3PhosphorylationBladder cancertumor tissueU23273076
[Reference]: In addition, patients with tumor recurrence had lower proportions of tumors with high phos-S6 (50% vs 69%, P = .04) and phos-4EBP1 (51% vs 69%, P = .05).
4PhosphorylationRenal cancer/carcinomaU16247451
[Reference]: siRNAs targeting casein kinase I gamma 3 (CSNK1G3) or the inositol polyphosphate multikinase (IPMK) significantly enhanced A-443654-mediated cell killing, and caused decreases in Akt Ser-473 and ribosomal protein S6 phosphorylation.
5Serine PhosphorylationKaposi's sarcomaUS23521819957
[Reference]: Phosphatase and tensin homolog on chromosome 10 is phosphorylated in primary effusion lymphoma and Kaposi's sarcoma.
6Serine PhosphorylationKaposi's sarcomaUS23621819957
[Reference]: Phosphatase and tensin homolog on chromosome 10 is phosphorylated in primary effusion lymphoma and Kaposi's sarcoma.
7Serine PhosphorylationLiver cancercell linePS240/24423537100
[Reference]: CCI-779 inhibited the phosphorylation of mTOR (Ser2448), p70S6K (Thr389), S6 (Ser240/244), and 4EBP1 (Thr37/46) in different grades and the expressions of p70S6K, S6, and 4EBP1. As a result, CCI-779 induced a dose-dependent decrease in cell proliferation, G1/S arrest and damage of cell shape
8Serine PhosphorylationTuberous sclerosis complexUS24017671177
[Reference]: Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer.
9Serine PhosphorylationTuberous sclerosis complexUS24417671177
[Reference]: Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)		MESH:D001943 ; Breast Neoplasms
MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D018450 ; Disease Progression
MESH:D013274 ; Stomach Neoplasms

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 18)
(view all)		 10        LNISFPATGCQKLIE     dbPAF
128       IPGLTDTTVPRRLGP     dbPAF
148       IRKLFNLSKEDDVRQ     dbPAF
181       PKIQRLVTPRVLQHK     dbPAF
209       NKEEAAEYAKLLAKR     dbPAF
235       IAKRRRLSSLRASTS     dbPAF
Acetylation
(count: 14)
(view all)		 116       LNLVIVKKGEKDIPG     PLMD
119       VIVKKGEKDIPGLTD     PLMD
14        FPATGCQKLIEVDDE     PLMD
143       KRASRIRKLFNLSKE     PLMD
149       RKLFNLSKEDDVRQY     PLMD
195       KRRRIALKKQRTKKN     PLMD
Ubiquitination
(count: 18)
(view all)		 115       VLNLVIVKKGEKDIP     PLMD
116       LNLVIVKKGEKDIPG     PLMD
119       VIVKKGEKDIPGLTD     PLMD
14        FPATGCQKLIEVDDE     PLMD
143       KRASRIRKLFNLSKE     PLMD
149       RKLFNLSKEDDVRQY     PLMD
Sumoylation
(count: 5)		 175       KPRTKAPKIQRLVTP     PLMD
203       KQRTKKNKEEAAEYA     PLMD
23        IEVDDERKLRTFYEK     PLMD
243       SLRASTSKSESSQK*     PLMD
249       SKSESSQK*******     PLMD
Malonylation
(count: 2)		 116       LNLVIVKKGEKDIPG     PLMD
211       EEAAEYAKLLAKRMK     PLMD
Succinylation
(count: 3)		 116       LNLVIVKKGEKDIPG     PLMD
149       RKLFNLSKEDDVRQY     PLMD
30        KLRTFYEKRMATEVA     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource